메뉴 건너뛰기




Volumn 21, Issue 24, 2014, Pages 2822-2829

Metabolic effects of bile acids in the gut in health and disease

Author keywords

Bile acids; Gut; Microbiota

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ADENYLATE CYCLASE; BILE ACID; CELL NUCLEUS RECEPTOR; CHENODEOXYCHOLIC ACID; CHOLESTEROL 7ALPHA MONOOXYGENASE; CHOLESTEROL ESTER TRANSFER PROTEIN; CHOLIC ACID; CONSTITUTIVE ANDROSTANE RECEPTOR; CYCLIC AMP; DEOXYCHOLIC ACID; FARNESOID X RECEPTOR; FIBROBLAST GROWTH FACTOR 19; FIBROBLAST GROWTH FACTOR RECEPTOR; G PROTEIN COUPLED RECEPTOR; GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; HEMOGLOBIN A1C; HEPATOCYTE NUCLEAR FACTOR 4; LITHOCHOLIC ACID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PREGNANE X RECEPTOR; PROTEIN KINASE; TAUROCHOLIC ACID; TAURODEOXYCHOLIC ACID; UNSATURATED FATTY ACID; URSODEOXYCHOLIC ACID; VITAMIN D RECEPTOR;

EID: 84903720102     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/0929867321666140303142053     Document Type: Article
Times cited : (31)

References (89)
  • 3
    • 0033026760 scopus 로고    scopus 로고
    • Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
    • Wang, H.; Chen, J.; Hollister, K.; Sowers, L. C.; Forman, B. M. Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol. Cell., 1999, 3, 543-553.
    • (1999) Mol. Cell , vol.3 , pp. 543-553
    • Wang, H.1    Chen, J.2    Hollister, K.3    Sowers, L.C.4    Forman, B.M.5
  • 8
    • 33751516736 scopus 로고
    • Studies in the bile acids. 3. The conjugated bile salts of certain primates
    • Wiggins, H. S.; Wootton, I. D. Studies in the bile acids. 3. The conjugated bile salts of certain primates. Biochem. J., 1958, 70, 349-352.
    • (1958) Biochem. J , vol.70 , pp. 349-352
    • Wiggins, H.S.1    Wootton, I.D.2
  • 9
    • 0017330763 scopus 로고
    • The enterohepatic circulation of conjugated bile acids in healthy man: Quantitative description and functions
    • Hofmann, A. F. The enterohepatic circulation of conjugated bile acids in healthy man: quantitative description and functions. Expos. Annu. Biochim. Med., 1977, 33, 69-86.
    • (1977) Expos. Annu. Biochim. Med , vol.33 , pp. 69-86
    • Hofmann, A.F.1
  • 12
    • 0035834771 scopus 로고    scopus 로고
    • Transcriptional regulation of the human sterol 12alpha-hydroxylase gene (cyp8b1) roles of hepatocyte nuclear factor-4alpha in mediating bile acid repression
    • Zhang, M.; Chiang, J. Y. L. Transcriptional Regulation of the Human Sterol 12alpha-Hydroxylase Gene (CYP8B1). Roles of hepatocyte nuclear factor-4alpha in mediating bile acid repression. J. Biol. Chem., 2001, 276, 41690-41699.
    • (2001) J. Biol. Chem , vol.276 , pp. 41690-41699
    • Zhang, M.1    Chiang, J.Y.L.2
  • 13
    • 0242380392 scopus 로고    scopus 로고
    • Regulation of human sterol 27-hydroxylase gene (CYP27A1) by bile acids and hepatocyte nuclear factor 4alpha (HNF4alpha)
    • Chen, W.; Chiang, J. Y. Regulation of human sterol 27-hydroxylase gene (CYP27A1) by bile acids and hepatocyte nuclear factor 4alpha (HNF4alpha). Gene, 2003, 313, 71-82.
    • (2003) Gene , vol.313 , pp. 71-82
    • Chen, W.1    Chiang, J.Y.2
  • 14
    • 0037160511 scopus 로고    scopus 로고
    • Functional analysis of the promoter of human sterol 27-hydroxylase gene in HepG2 cells
    • DOI 10.1016/S0378-1119(01)00874-5, PII S0378111901008745
    • Garuti, R.; Croce, M. A.; Piccinini, L.; Tiozzo, R.; Bertolini, S.; Calandra, S. Functional analysis of the promoter of human sterol 27-hydroxylase gene in HepG2 cells. Gene, 2002, 283, 133-143. (Pubitemid 34178517)
    • (2002) Gene , vol.283 , Issue.1-2 , pp. 133-143
    • Garuti, R.1    Croce, M.A.2    Piccinini, L.3    Tiozzo, R.4    Bertolini, S.5    Calandra, S.6
  • 15
    • 0037071854 scopus 로고    scopus 로고
    • On the mechanism of bile acid inhibition of rat sterol 12alpha-hydroxylase gene (CYP8B1) transcription: Roles of alpha-fetoprotein transcription factor and hepatocyte nuclear factor 4alpha
    • Yang, Y.; Zhang, M.; Eggertsen, G.; Chiang, J. Y. On the mechanism of bile acid inhibition of rat sterol 12alpha-hydroxylase gene (CYP8B1) transcription: roles of alpha-fetoprotein transcription factor and hepatocyte nuclear factor 4alpha. Biochim. Biophys. Acta, 2002, 1583, 63-73.
    • (2002) Biochim. Biophys. Acta , vol.1583 , pp. 63-73
    • Yang, Y.1    Zhang, M.2    Eggertsen, G.3    Chiang, J.Y.4
  • 16
    • 34848866633 scopus 로고    scopus 로고
    • Liverspecific activities of FGF19 require Klotho beta
    • Lin, B. C.; Wang, M.; Blackmore, C.; Desnoyers, L. R. Liverspecific activities of FGF19 require Klotho beta. J. Biol. Chem., 2007, 282, 27277-27284.
    • (2007) J. Biol. Chem , vol.282 , pp. 27277-27284
    • Lin, B.C.1    Wang, M.2    Blackmore, C.3    Desnoyers, L.R.4
  • 19
    • 70349255713 scopus 로고    scopus 로고
    • The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders
    • Keitel, V.; Cupisti, K.; Ullmer, C.; Knoefel, W. T.; Kubitz, R.; Haussinger, D. The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders. Hepatology, 2009, 50, 861-870.
    • (2009) Hepatology , vol.50 , pp. 861-870
    • Keitel, V.1    Cupisti, K.2    Ullmer, C.3    Knoefel, W.T.4    Kubitz, R.5    Haussinger, D.6
  • 20
    • 78649386642 scopus 로고    scopus 로고
    • The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain
    • Keitel, V.; Gorg, B.; Bidmon, H. J.; Zemtsova, I.; Spomer, L.; Zilles, K.; Haussinger, D. The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain. Glia, 2010, 58, 1794-1805.
    • (2010) Glia , vol.58 , pp. 1794-1805
    • Keitel, V.1    Gorg, B.2    Bidmon, H.J.3    Zemtsova, I.4    Spomer, L.5    Zilles, K.6    Haussinger, D.7
  • 22
    • 41149144697 scopus 로고    scopus 로고
    • Novel potent and selective bile acid derivatives as TGR5 agonists: Biological screening structure-activity relationships, and molecular modeling studies
    • Sato, H.; Macchiarulo, A.; Thomas, C.; Gioiello, A.; Une, M.; Hofmann, A. F.; Saladin, R.; Schoonjans, K.; Pellicciari, R.; Auwerx, J. Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies. J. Med. Chem., 2008, 51, 1831-1841.
    • (2008) J. Med. Chem , vol.51 , pp. 1831-1841
    • Sato, H.1    MacChiarulo, A.2    Thomas, C.3    Gioiello, A.4    Une, M.5    Hofmann, A.F.6    Saladin, R.7    Schoonjans, K.8    Pellicciari, R.9    Auwerx, J.10
  • 23
    • 0010612265 scopus 로고
    • Studies on the antibacterial properties of the bile acids and some compounds derived from cholanic acid
    • Stacey, M.; Webb, M. Studies on the antibacterial properties of the bile acids and some compounds derived from cholanic acid. Proc. R. Soc. Med., 1947, 134, 523-537.
    • (1947) Proc. R. Soc. Med , vol.134 , pp. 523-537
    • Stacey, M.1    Webb, M.2
  • 26
    • 33644752102 scopus 로고    scopus 로고
    • Mechanism of growth inhibition by free bile acids in lactobacilli and bifidobacteria
    • DOI 10.1128/JB.188.5.1979-1986.2006
    • Kurdi, P.; Kawanishi, K.; Mizutani, K.; Yokota, A. Mechanism of growth inhibition by free bile acids in Lactobacilli and Bifidobacteria. J. Bacteriol., 2006, 188, 1979-1986. (Pubitemid 43346878)
    • (2006) Journal of Bacteriology , vol.188 , Issue.5 , pp. 1979-1986
    • Kurdi, P.1    Kawanishi, K.2    Mizutani, K.3    Yokota, A.4
  • 33
    • 41849127118 scopus 로고    scopus 로고
    • Dietinduced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome
    • Turnbaugh, P. J.; Backhed, F.; Fulton, L.; Gordon, J. I. Dietinduced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell. Host Microbe, 2008, 3, 213-223.
    • (2008) Cell. Host Microbe , vol.3 , pp. 213-223
    • Turnbaugh, P.J.1    Backhed, F.2    Fulton, L.3    Gordon, J.I.4
  • 35
    • 0036844404 scopus 로고    scopus 로고
    • Immune responses to bile-tolerant helicobacter species in patients with chronic liver diseases a randomized population group, and healthy blood donors
    • Ananieva, O.; Nilsson, I.; Vorobjova, T.; Uibo, R.; Wadstrom, T. Immune responses to bile-tolerant helicobacter species in patients with chronic liver diseases, a randomized population group, and healthy blood donors. Clin. Diagn. Lab. Immunol., 2002, 9, 1160-1164.
    • (2002) Clin. Diagn. Lab. Immunol , vol.9 , pp. 1160-1164
    • Ananieva, O.1    Nilsson, I.2    Vorobjova, T.3    Uibo, R.4    Wadstrom, T.5
  • 36
    • 0036037505 scopus 로고    scopus 로고
    • European Listeria Genome Consortium Listeria monocytogenes bile salt hydrolase is a PrfA-regulated virulence factor involved in the intestinal and hepatic phases of listeriosis
    • Dussurget, O.; Cabanes, D.; Dehoux, P.; Lecuit, M.; Buchrieser, C.; Glaser, P.; Cossart, P. European Listeria Genome Consortium Listeria monocytogenes bile salt hydrolase is a PrfA-regulated virulence factor involved in the intestinal and hepatic phases of listeriosis. Mol. Microbiol., 2002, 45, 1095-1106.
    • (2002) Mol. Microbiol , vol.45 , pp. 1095-1106
    • Dussurget, O.1    Cabanes, D.2    Dehoux, P.3    Lecuit, M.4    Buchrieser, C.5    Glaser, P.6    Cossart, P.7
  • 37
    • 0036285079 scopus 로고    scopus 로고
    • Sulfate-reducing bacteria in human feces and their association with inflammatory bowel diseases
    • Loubinoux, J.; Bronowicki, J. P.; Pereira, I. A.; Mougenel, J. L.; Faou, A. E. Sulfate-reducing bacteria in human feces and their association with inflammatory bowel diseases. FEMS Microbiol. Ecol., 2002, 40, 107-112.
    • (2002) FEMS Microbiol. Ecol , vol.40 , pp. 107-112
    • Loubinoux, J.1    Bronowicki, J.P.2    Pereira, I.A.3    Mougenel, J.L.4    Faou, A.E.5
  • 38
    • 60049100513 scopus 로고    scopus 로고
    • Sulphate-reducing bacteria and hydrogen sulphide in the aetiology of ulcerative colitis
    • Rowan, F. E.; Docherty, N. G.; Coffey, J. C.; O'Connell, P. R. Sulphate-reducing bacteria and hydrogen sulphide in the aetiology of ulcerative colitis. Br. J. Surg., 2009, 96, 151-158.
    • (2009) Br. J. Surg , vol.96 , pp. 151-158
    • Rowan, F.E.1    Docherty, N.G.2    Coffey, J.C.3    O'Connell, P.R.4
  • 39
    • 0030980121 scopus 로고    scopus 로고
    • Taurine reduction in anaerobic respiration of Bilophila wadsworthia RZATAU
    • Laue, H.; Denger, K.; Cook, A. M. Taurine reduction in anaerobic respiration of Bilophila wadsworthia RZATAU. Appl. Environ. Microbiol., 1997, 63, 2016-2021.
    • (1997) Appl. Environ. Microbiol , vol.63 , pp. 2016-2021
    • Laue, H.1    Denger, K.2    Cook, A.M.3
  • 40
    • 0031126706 scopus 로고    scopus 로고
    • Bilophila wadsworthia: A unique gram-negative anaerobic rod
    • DOI 10.1006/anae.1997.0075
    • Baron, E. J. Bilophila wadsworthia: a unique Gram-negative anaerobic rod. Anaerobe, 1997, 3, 83-86. (Pubitemid 27423129)
    • (1997) Anaerobe , vol.3 , Issue.2-3 , pp. 83-86
    • Baron, E.J.1
  • 41
    • 0013873394 scopus 로고
    • And elimination of cholesterol in germfree rats
    • Wostmann, B. S.; Wiech, N. L.; Kung, E. Catabolism and elimination of cholesterol in germfree rats. J. Lipid Res., 1966, 7, 77-82.
    • (1966) J. Lipid Res , vol.7 , pp. 77-82
    • Wostmann, B.S.1    Wiech, N.L.2    Catabolism, K.E.3
  • 42
    • 0015781684 scopus 로고
    • Intestinal bile acids and cholesterol absorption in the germfree rat
    • Wostmann, B. S. Intestinal bile acids and cholesterol absorption in the germfree rat. J. Nutr., 1973, 103, 982-990.
    • (1973) J. Nutr , vol.103 , pp. 982-990
    • Wostmann, B.S.1
  • 43
    • 78650785669 scopus 로고    scopus 로고
    • Enterobacteria modulate intestinal bile acid transport and homeostasis through apical sodium-dependent bile acid transporter (SLC10A2) expression
    • Miyata, M.; Yamakawa, H.; Hamatsu, M.; Kuribayashi, H.; Takamatsu, Y.; Yamazoe, Y. Enterobacteria modulate intestinal bile acid transport and homeostasis through apical sodium-dependent bile acid transporter (SLC10A2) expression. J. Pharmacol. Exp. Ther., 2011, 336, 188-196.
    • (2011) J. Pharmacol. Exp. Ther , vol.336 , pp. 188-196
    • Miyata, M.1    Yamakawa, H.2    Hamatsu, M.3    Kuribayashi, H.4    Takamatsu, Y.5    Yamazoe, Y.6
  • 46
    • 73349101418 scopus 로고    scopus 로고
    • Administration of ampicillin elevates hepatic primary bile acid synthesis through suppression of ileal fibroblast growth factor 15 expression
    • Miyata, M.; Takamatsu, Y.; Kuribayashi, H.; Yamazoe, Y. Administration of ampicillin elevates hepatic primary bile acid synthesis through suppression of ileal fibroblast growth factor 15 expression. J. Pharmacol. Exp. Ther., 2009, 331, 1079-1085.
    • (2009) J. Pharmacol. Exp. Ther , vol.331 , pp. 1079-1085
    • Miyata, M.1    Takamatsu, Y.2    Kuribayashi, H.3    Yamazoe, Y.4
  • 47
    • 0024424884 scopus 로고
    • Insulinotropic properties of synthetic human gastric inhibitory polypeptide in man: Interactions with glucose, phenylalanine, and cholecystokinin-8
    • Nauck, M.; Schmidt, W. E.; Ebert, R.; Strietzel, J.; Cantor, P.; Hoffmann, G.; Creutzfeldt, W. Insulinotropic properties of synthetic human gastric inhibitory polypeptide in man: interactions with glucose, phenylalanine, and cholecystokinin-8. J. Clin. Endocrinol. Metab., 1989, 69, 654-662. (Pubitemid 19221242)
    • (1989) Journal of Clinical Endocrinology and Metabolism , vol.69 , Issue.3 , pp. 654-662
    • Nauck, M.1    Schmidt, W.E.2    Ebert, R.3    Strietzel, J.4    Cantor, P.5    Hoffmann, G.6    Creutzfeldt, W.7
  • 48
    • 0023638829 scopus 로고
    • Glucagon-like peptide-1 7-36 a physiological incretin in man
    • Kreymann, B.; Williams, G.; Ghatei, M. A.; Bloom, S. R. Glucagon-like peptide-1 7-36: a physiological incretin in man. Lancet, 1987, 2, 1300-1304.
    • (1987) Lancet , vol.2 , pp. 1300-1304
    • Kreymann, B.1    Williams, G.2    Ghatei, M.A.3    Bloom, S.R.4
  • 49
    • 77956648921 scopus 로고    scopus 로고
    • Colesevelam HCl improves glucose metabolism and increases plasma glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide concentrations in subjects with type 2 diabetes
    • Beysen, C.; Deines, K. C.; Tsang, E. L.; Murphy, E. J.; Chan, M.; Edmonds, J. M.; Neese, R. A.; Hellerstein, M. K. Colesevelam HCl improves glucose metabolism and increases plasma glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide concentrations in subjects with type 2 diabetes. Diabetologia, 2009, 52, s77.
    • (2009) Diabetologia , vol.52
    • Beysen, C.1    Deines, K.C.2    Tsang, E.L.3    Murphy, E.J.4    Chan, M.5    Edmonds, J.M.6    Neese, R.A.7    Hellerstein, M.K.8
  • 50
    • 0037784011 scopus 로고    scopus 로고
    • GLP-1 and GIP are colocalized in a subset of endocrine cells in the small intestine
    • Mortensen, K.; Christensen, L. L.; Holst, J. J.; Orskov, C. GLP-1 and GIP are colocalized in a subset of endocrine cells in the small intestine. Regul. Pept., 2003, 114, 189-196.
    • (2003) Regul. Pept , vol.114 , pp. 189-196
    • Mortensen, K.1    Christensen, L.L.2    Holst, J.J.3    Orskov, C.4
  • 51
    • 35748957503 scopus 로고    scopus 로고
    • The physiology of glucagon-like peptide 1
    • Holst, J. J. The physiology of glucagon-like peptide 1. Physiol. Rev., 2007, 87, 1409-1439.
    • (2007) Physiol. Rev , vol.87 , pp. 1409-1439
    • Holst, J.J.1
  • 52
    • 0028838030 scopus 로고
    • Glucagon-like peptide-1 and glucose-dependent insulinreleasing polypeptide plasma levels in response to nutrients
    • Herrmann, C.; Goke, R.; Richter, G.; Fehmann, H. C.; Arnold, R.; Goke, B. Glucagon-like peptide-1 and glucose-dependent insulinreleasing polypeptide plasma levels in response to nutrients. Digestion, 1995, 56, 117-126.
    • (1995) Digestion , vol.56 , pp. 117-126
    • Herrmann, C.1    Goke, R.2    Richter, G.3    Fehmann, H.C.4    Arnold, R.5    Goke, B.6
  • 53
    • 82555189369 scopus 로고    scopus 로고
    • Potential new approaches to modifying intestinal GLP-1 secretion in patients with type 2 diabetes mellitus: Focus on bile acid sequestrants
    • Holst, J. J.; McGill, M. A. Potential new approaches to modifying intestinal GLP-1 secretion in patients with type 2 diabetes mellitus: focus on bile acid sequestrants. Clin. Drug Investig., 2012, 32, 1-14.
    • (2012) Clin. Drug Investig , vol.32 , pp. 1-14
    • Holst, J.J.1    McGill, M.A.2
  • 57
    • 70149108533 scopus 로고    scopus 로고
    • Serum bile acid along with plasma incretins and serum high-molecular weight adiponectin levels are increased after bariatric surgery
    • Nakatani, H.; Kasama, K.; Oshiro, T.; Watanabe, M.; Hirose, H.; Itoh, H. Serum bile acid along with plasma incretins and serum high-molecular weight adiponectin levels are increased after bariatric surgery. Metabolism, 2009, 58, 1400-1407.
    • (2009) Metabolism , vol.58 , pp. 1400-1407
    • Nakatani, H.1    Kasama, K.2    Oshiro, T.3    Watanabe, M.4    Hirose, H.5    Itoh, H.6
  • 58
    • 84855850294 scopus 로고    scopus 로고
    • Bile acid sequestrants: More than simple resins
    • Out, C.; Groen, A. K.; Brufau, G. Bile acid sequestrants: more than simple resins. Curr. Opin. Lipidol., 2012, 23, 43-55.
    • (2012) Curr. Opin. Lipidol , vol.23 , pp. 43-55
    • Out, C.1    Groen, A.K.2    Brufau, G.3
  • 60
    • 77249142314 scopus 로고    scopus 로고
    • Colesevelam improves insulin resistance in a diet-induced obesity (F-DIO) rat model by increasing the release of GLP-1
    • Shang, Q.; Saumoy, M.; Holst, J. J.; Salen, G.; Xu, G. Colesevelam improves insulin resistance in a diet-induced obesity (F-DIO) rat model by increasing the release of GLP-1. Am. J. Physiol. Gastrointest. Liver Physiol., 2010, 298, G419-G424.
    • (2010) Am. J. Physiol. Gastrointest. Liver Physiol , vol.298
    • Shang, Q.1    Saumoy, M.2    Holst, J.J.3    Salen, G.4    Xu, G.5
  • 64
    • 77951523535 scopus 로고    scopus 로고
    • Association of pancreatitis with glucagon-like peptide-1 agonist use
    • Anderson, S. L.; Trujillo, J. M. Association of pancreatitis with glucagon-like peptide-1 agonist use. Ann. Pharmacother., 2010, 44, 904-909.
    • (2010) Ann. Pharmacother , vol.44 , pp. 904-909
    • Anderson, S.L.1    Trujillo, J.M.2
  • 66
    • 84869217988 scopus 로고    scopus 로고
    • Efficacy and safety of dipeptidyl peptidase-4 inhibitors in type 2 diabetes: Meta-analysis
    • Park, H.; Park, C.; Kim, Y.; Rascati, K. L. Efficacy and safety of dipeptidyl peptidase-4 inhibitors in type 2 diabetes: meta-analysis. Ann. Pharmacother., 2012, 46, 1453-1469.
    • (2012) Ann. Pharmacother , vol.46 , pp. 1453-1469
    • Park, H.1    Park, C.2    Kim, Y.3    Rascati, K.L.4
  • 68
    • 33645738747 scopus 로고    scopus 로고
    • Endocrine functions of bile acids
    • Houten, S. M.; Watanabe, M.; Auwerx, J. Endocrine functions of bile acids. EMBO J., 2006, 25, 1419-1425.
    • (2006) EMBO J , vol.25 , pp. 1419-1425
    • Houten, S.M.1    Watanabe, M.2    Auwerx, J.3
  • 73
    • 37249015421 scopus 로고    scopus 로고
    • Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine
    • DOI 10.1194/jlr.M700330-JLR200
    • Kim, I.; Ahn, S. H.; Inagaki, T.; Choi, M.; Ito, S.; Guo, G. L.; Kliewer, S. A.; Gonzalez, F. J. Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine. J. Lipid Res., 2007, 48, 2664-2672. (Pubitemid 350272851)
    • (2007) Journal of Lipid Research , vol.48 , Issue.12 , pp. 2664-2672
    • Kim, I.1    Ahn, S.-H.2    Inagaki, T.3    Choi, M.4    Ito, S.5    Guo, G.L.6    Kliewer, S.A.7    Gonzalez, F.J.8
  • 74
    • 56149085041 scopus 로고    scopus 로고
    • Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response
    • Wang, Y. D.; Chen, W. D.; Wang, M.; Yu, D.; Forman, B. M.; Huang, W. Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response. Hepatology, 2008, 48, 1632-1643.
    • (2008) Hepatology , vol.48 , pp. 1632-1643
    • Wang, Y.D.1    Chen, W.D.2    Wang, M.3    Yu, D.4    Forman, B.M.5    Huang, W.6
  • 75
    • 67349101194 scopus 로고    scopus 로고
    • Reciprocal regulation of the bile acid-activated receptor FXR and the interferon-gamma-STAT-1 pathway in macrophages
    • Renga, B.; Migliorati, M.; Mencarelli, A.; Fiorucci, S. Reciprocal regulation of the bile acid-activated receptor FXR and the interferon-gamma- STAT-1 pathway in macrophages. Biochim. Biophys. Acta, 2009, 1792, 564-573.
    • (2009) Biochim. Biophys. Acta , vol.1792 , pp. 564-573
    • Renga, B.1    Migliorati, M.2    Mencarelli, A.3    Fiorucci, S.4
  • 78
    • 77149159568 scopus 로고    scopus 로고
    • The bile acid receptor FXR is a modulator of intestinal innate immunity
    • Vavassori, P.; Mencarelli, A.; Renga, B.; Distrutti, E.; Fiorucci, S. The bile acid receptor FXR is a modulator of intestinal innate immunity. J. Immunol., 2009, 183, 6251-6261.
    • (2009) J. Immunol , vol.183 , pp. 6251-6261
    • Vavassori, P.1    Mencarelli, A.2    Renga, B.3    Distrutti, E.4    Fiorucci, S.5
  • 80
    • 84865484646 scopus 로고    scopus 로고
    • Anti-inflammatory and metabolic actions of FXR: Insights into molecular mechanisms
    • Hollman, D. A.; Milona, A.; van Erpecum, K. J.; van Mil, S. W. Anti-inflammatory and metabolic actions of FXR: Insights into molecular mechanisms. Biochim. Biophys. Acta, 2012, 1821, 1443-1452.
    • (2012) Biochim. Biophys. Acta , vol.1821 , pp. 1443-1452
    • Hollman, D.A.1    Milona, A.2    Van Erpecum, K.J.3    Van Mil, S.W.4
  • 82
  • 83
    • 0037392389 scopus 로고    scopus 로고
    • Review article: Pruritus in cholestatic and other liver diseases
    • Mela, M.; Mancuso, A.; Burroughs, A. K. Review article: pruritus in cholestatic and other liver diseases. Aliment. Pharmacol. Ther., 2003, 17, 857-870.
    • (2003) Aliment. Pharmacol. Ther , vol.17 , pp. 857-870
    • Mela, M.1    Mancuso, A.2    Burroughs, A.K.3
  • 87
    • 30944467225 scopus 로고    scopus 로고
    • Endogenous glucagon-like peptide 1 controls endocrine pancreatic secretion and antro-pyloro-duodenal motility in humans
    • DOI 10.1136/gut.2004.059741
    • Schirra, J.; Nicolaus, M.; Roggel, R.; Katschinski, M.; Storr, M.; Woerle, H. J.; Goke, B. Endogenous glucagon-like peptide 1 controls endocrine pancreatic secretion and antro-pyloro-duodenal motility in humans. Gut, 2006, 55, 243-251. (Pubitemid 43117285)
    • (2006) Gut , vol.55 , Issue.2 , pp. 243-251
    • Schirra, J.1    Nicolaus, M.2    Roggel, R.3    Katschinski, M.4    Storr, M.5    Woerle, H.J.6    Goke, B.7
  • 89


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.