Two interdependent mechanisms of antimicrobial activity allow for efficient killing in nylon-3-based polymeric mimics of innate immunity peptides

Biochimica et Biophysica Acta - Biomembranes

Volumn 1838, Issue 9, 2014, Pages 2269-2279

  Lee, Michelle W ^a   Chakraborty, Saswata ^b   Schmidt, Nathan W ^a   Murgai, Rajan ^a   Gellman, Samuel H ^b   Wong, Gerard C L ^a,c  

^a Engineering IV   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

antimicrobial peptides; innate immunity; membrane curvature; membrane permeation; peptide lipid interactions; pore formation

Indexed keywords

ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; NYLON; NYLON 3 POLYMER A; NYLON 3 POLYMER B; NYLON 3 POLYMER C 1; NYLON 3 POLYMER C 2; NYLON 3 POLYMER C 3; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL CELL; BACTERIAL MEMBRANE; BINDING AFFINITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DNA BINDING; DRUG STRUCTURE; ESCHERICHIA COLI; LIPID COMPOSITION; MEMBRANE DAMAGE; MEMBRANE PERMEABILITY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL;

ANTIMICROBIAL PEPTIDES; INNATE IMMUNITY; MEMBRANE CURVATURE; MEMBRANE PERMEATION; PEPTIDE-LIPID INTERACTIONS; PORE FORMATION;

ANTIMICROBIAL CATIONIC PEPTIDES; BACTERIA; BACTERIAL INFECTIONS; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; ESCHERICHIA COLI; HUMANS; IMMUNITY, INNATE; LIPID BILAYERS; NYLONS; POLYMERS;

EID: 84903647902     PISSN: 00052736     EISSN: 18792642     Source Type: Journal    
DOI: 10.1016/j.bbamem.2014.04.007     Document Type: Article

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