Exploiting current understanding of antibiotic action for discovery of new drugs

Journal of Applied Microbiology Symposium Supplement

Volumn 92, Issue 1, 2002, Pages

  Chopra, I ^a   Hesse, L ^a   O'Neill, A J ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

7 [[(2 AMINO 3 METHYLPENTANOYL)AMINOSULFONYL]ACETAMIDO] 4 CARBAMOYL 2,4A,5,6,7,7A HEXAHYDRO 6 HYDROXY 2 METHYL 1H 2 PYRINDINE 7 CARBOXYLIC ACID; 7 [[(2 AMINO 3 METHYLPENTANOYL)AMINOSULFONYL]ACETAMIDO] 6 (2 AMINO 3 PHENYLBUTANOYLOXY) 4 CARBAMOYL 2,4A,5,6,7,7A HEXAHYDRO 2 METHYL 1H 2 PYRINDINE 7 CARBOXYLIC ACID; AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIBIOTIC AGENT; BACITRACIN; BETA LACTAM ANTIBIOTIC; CHLORAMPHENICOL; CIPROFLOXACIN; COUMARIN; CYCLOSERINE; CYCLOTHIALIDINE; DNA DIRECTED RNA POLYMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); FOLIC ACID; FOSFOMYCIN; FUSIDIC ACID; GLYCOPEPTIDE; MACROLIDE; OXAZOLIDINONE DERIVATIVE; PSEUDOMONIC ACID; QUINOLONE DERIVATIVE; RIFABUTIN; RIFALAZIL; RIFAMYCIN; RIFAPENTINE; SB 217452; STREPTOGRAMIN; STREPTOLYDIGIN; SULFONAMIDE; SV 219383; TETRACYCLINE DERIVATIVE; TRIMETHOPRIM; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZWITTERMICIN; ANTIINFECTIVE AGENT;

ANTIBIOTIC RESISTANCE; ANTIMICROBIAL ACTIVITY; BACTERIAL INFECTION; CHEMOTHERAPY; CONFERENCE PAPER; DNA REPLICATION; DNA TRANSCRIPTION; DRUG MECHANISM; DRUG RESEARCH; DRUG SCREENING; DRUG TARGETING; HUMAN; NONHUMAN; PROTEIN SYNTHESIS; RNA SYNTHESIS; STRUCTURE ACTIVITY RELATION; BACTERIAL PHENOMENA AND FUNCTIONS; BACTERIUM; DRUG DESIGN; DRUG EFFECT; MICROBIOLOGICAL EXAMINATION; REVIEW;

ANTI-BACTERIAL AGENTS; BACTERIAL INFECTIONS; DRUG DESIGN; HUMANS; BACTERIA; BACTERIAL PHYSIOLOGY; DRUG RESISTANCE, BACTERIAL; MICROBIAL SENSITIVITY TESTS;

BACTERIA (MICROORGANISMS);

EID: 0036090890     PISSN: 02674440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (78)

1. Specificity of the uridine-diphosphate-N-acetylmuramyl-L-alanyl-D-glutamate-meso-2, 6-diaminopimelate synthetase from Escherichia coli
2. Extensive homology among the largest subunits of eukaryotic and prokaryotic RNA polymerases
3. New antibiotic that acts specifically on the GTP-bound form of elongation factor Tu
4. Initiation by the DNA dependent RNA polymerase
5. Characterization of mutations in the rpoB gene that confer rifampin resistance in Staphylococcus aureus
6. Synthesis and activity of analogues of SB-219383: Novel potent inhibitors of bacterial tyrosyl tRNA synthetase
7. Crystal structure of UDP-N-acetylmuramoyl-L-alanine: D-glutamate ligase from Escherichia coli
8. New agents for Gram-positive bacteria
9. Will genomics revolutionize antimicrobial drug discovery?
10. Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics
11. Emergent antibiotic resistance: Health risks and economic impact
12. Protein synthesis as a target for antibacterial drugs: Current status and future opportunities
13. Approaches for the discovery of new antibacterial agents
14. New drugs for the superbugs
15. Molecular action of anti-mycobacterial agents
16. Antimicrobial agents: Basis of action
17. New approaches to the control of infections caused by antibiotic-resistant bacteria - An industry perspective
18. The search for antimicrobial agents effective against bacteria resistant to multiple antibiotics
19. Recent progress in novel macrolides, quinolones, and 2-pyridones to overcome bacterial resistance
20. Changing patterns of infectious disease
21. Recognition sites for antibiotics within rRNA
22. Inactivation of antibiotics and the dissemination of resistance genes
23. A strategy for fighting antibiotic resistance
24. RNA polymerase: Structural similarities between bacterial RNA polymerase and eukaryotic RNA polymerase II
25. From initiation to elongation - Comparison of transcription by prokaryotic and eukaryotic RNA polymerases
26. Comparative studies of RNA polymerase subunits from various bacteria
27. Searching for drug targets in microbial genomes
28. Design, synthesis, and X-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumour agent
29. Inhibitors of the bacterial cell wall biosynthesis enzyme MurD
30. Crystal structure of UDP-N-acetylmuramoyl-L-alanyl-D-glutamate: Meso-diaminopimelate ligase from Escherichia coli
31. The corallopyronins, new inhibitors of bacterial RNA synthesis from Myxobacteria
32. The ripostatins, novel inhibitors of eubacterial RNA polymerase isolated from Myxobacteria
33. In vitro and in vivo antibacterial activities of TAK-083 an agent for treatment of Helicobacter pylori infection
34. Inhibition of messenger ribonucleic acid synthesis in Escherichia coli by thiolutin
35. Selective inhibition of the bacterial peptidoglycan biosynthesis by the new types of liposidomycins
36. New strategies for antibacterial drug design
37. Biosynthesis of ansamycins
38. Are all beta-lactams created equal?
39. Screening systems for detecting inhibitors of cell wall transglycosy-lation in Enterococcus - Cell wall transglycosylation inhibitors in Enterococcus
40. DNA gyrase as a drug target
41. Bacterial RNA polymerase subunit omega and eukaryotic RNA polymerase subunit RPB6 are sequence, structural, and functional homologs and promote RNA polymerase assembly
42. Interaction of antibiotics with functional sites in 16S ribosomal RNA
43. Genomics and antimicrobial drug discovery
44. Genetic analysis of Staphylococcus aureus RNA polymerase mutants
45. RNA polymerase inhibitors with activity against rifampin-resistant mutants of Staphylococcus aureus
46. Antimicrobial properties and mode of action of the pyrrothine holomycin
47. Direct localization of a beta-subunit domain on the three-dimensional structure of Escherichia coli RNA polymerase
48. Rifamycins
49. Mechanism of action of kirromycin-like antibiotics
50. 70), promoters, and the kinetics of transcription initiation
51. Inhibitors of bacterial cell wall synthesis
52. Myxobacteria as producers of secondary metabolites
53. Resistance of Escherichia coli to rifampicin and sorangicin A - A comparison
54. Harnessing the power of the genome in the search for new antibiotics
55. RNA polymerase structure-function: Insights into points of transcriptional regulation
56. The Beta subunit rif cluster I is only angstroms away from the active center of Escherichia coli RNA polymerase
57. Mechanism of action of the oxazolidinone antibacterial agents
58. Discovery and development of new antibiotics: The problem of antibiotic resistance
59. Synthesis and evaluation of Streptococcus pneumoniae MurD transition state inhibitors
60. Genetic analysis of zwittermicin A resistance in Escherichia coli: Effects on membrane potential and RNA polymerase
61. SB-203207 and SB-203208, two novel isoleucyl tRNA synthetase inhibitors from a Streptomyces sp. I. Fermentation, isolation and properties
62. SB-219383, a novel tyrosyl tRNA synthetase inhibitor from a Micromonospora sp. I. Fermentation, isolation and properties
63. A potent seryl tRNA synthetase inhibitor SB-217452 isolated from a Streptomyces species
64. Phosphinate inhibitors of the D-glutamic acid-adding enzyme of peptidoglycan biosynthesis
65. Inhibitors of aminoacyl-tRNA synthetases as novel anti-infectives
66. Drug target validation: Lethal infection blocked by inducible peptide
67. History and future of antimicrobial diaminopyrim-idines
68. Murein Synthesis
69. Dihydropteroate synthase: An old drug target revisited
70. A simple screen for murein transglycosylase inhibitors
71. New antifolate 4,4′-diaminodiphenyl sulfone substituted 2,4-diamino-5-benzylpyrimidines. Proof of their dual mode of action and autosynergism
72. Crystal structure of Escherichia coli UDPMurNAc-tripeptide D-alanyl-D-alanine-adding enzyme (MurF) at 2.3 A resolution
73. Relationship between antimycobacterial activities of rifampicin, rifabutin and KRM-1648 and rpoB mutations of Mycobacterium tuberculosis
74. The need for new antibiotics: Possible ways forward
75. Crystal structure of Thermus aquaticus core RNA polymerase at 3.3 angstrom resolution