Rational design of α-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index

Journal of Biological Chemistry

Volumn 280, Issue 13, 2005, Pages 12316-12329

  Chen, Yuxin ^a   Mant, Colin T ^a   Farmer, Susan W ^b   Hancock, Robert E W ^b   Vasil, Michael L ^a   Hodges, Robert S ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BACTERIA; BIOCHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHILICITY; HYDROPHOBICITY; MICROBIOLOGY; MOLECULES;

ANTIMICROBIAL ACTIVITY; HEMOLYTIC ACTIVITIES; HIGH HELICITY; RATIONAL DESIGN;

POLYPEPTIDES;

ANTIINFECTIVE AGENT; N ALPHA ACETYLLYSYLTRYPTOPHYLLYSYLSERYLPHENYLALANYLLEUCYLLYSYLTHREONYLPHENYLALANYLLYSYL ALANYLALANYL DEXTRO VALYLLYSYLTHREONYLVALYLLEUCYLHISTIDYLTHREONYLALANYLLEUCYLLYSYLALANYLISOLEUCYL SERYLSERINAMIDE; N ALPHA ACETYLLYSYLTRYPTOPHYLLYSYLSERYLPHENYLALANYLLEUCYLLYSYLTHREONYLPHENYLALANYLLYSYL ALANYLALANYLVALYLLYSYLTHREONYLVALYLLEUCYLHISTIDYLTHREONYLALANYLLEUCYLLYSYL ALANYLISOLEUCYLSERYLSERINAMIDE; N ALPHA ACETYLLYSYLTRYPTOPHYLLYSYLSERYLPHENYLALANYLLEUCYLLYSYLTHREONYLPHENYLALANYLLYSYL DEXTRO ALANYLALANYLVALYLLYSYLTHREONYLVALYLLEUCYLHISTIDYLTHREONYLALANYLLEUCYLLYSYL ALANYLISOLEUCYLSERYLSERINAMIDE; N ALPHA ACETYLLYSYLTRYPTOPHYLLYSYLSERYLPHENYLALANYLLEUCYLLYSYLTHREONYLPHENYLALANYLLYSYL DEXTRO GLYCYLALANYLGLYCYLLYSYLTHREONYLVALYLLEUCYLHISTIDYLTHREONYLALANYLLEUCYLLYSYL ALANYLISOLEUCYLSERYLSERINAMIDE; N ALPHA ACETYLLYSYLTRYPTOPHYLLYSYLSERYLPHENYLALANYLLEUCYLLYSYLTHREONYLPHENYLALANYLLYSYL DEXTRO LEUCYLALANYLLEUCYLLYSYLTHREONYLVALYLLEUCYLHISTIDYLTHREONYLALANYLLEUCYLLYSYL ALANYLISOLEUCYLSERYLSERINAMIDE; N ALPHA ACETYLLYSYLTRYPTOPHYLLYSYLSERYLPHENYLALANYLLEUCYLLYSYLTHREONYLPHENYLALANYLLYSYL DEXTRO LYSYLALANYLLYSYLLYSYLTHREONYLVALYLLEUCYLHISTIDYLTHREONYLALANYLLEUCYLLYSYLALANYL ISOLEUCYLSERYLSERINAMIDE; N ALPHA ACETYLLYSYLTRYPTOPHYLLYSYLSERYLPHENYLALANYLLEUCYLLYSYLTHREONYLPHENYLALANYLLYSYL DEXTRO SERYLALANYLALANYLLYSYLTHREONYLVALYLLEUCYLHISTIDYLTHREONYLALANYLLEUCYLLYSYL ALANYLISOLEUCYLSERYLSERINAMIDE; N ALPHA ACETYLLYSYLTRYPTOPHYLLYSYLSERYLPHENYLALANYLLEUCYLLYSYLTHREONYLPHENYLALANYLLYSYL DEXTRO VALYLALANYLSERYLLYSYLTHREONYLVALYLLEUCYLHISTIDYLTHREONYLALANYLLEUCYLLYSYLALANYL ISOLEUCYLSERYLSERINAMIDE; N ALPHA ACETYLLYSYLTRYPTOPHYLLYSYLSERYLPHENYLALANYLLEUCYLLYSYLTHREONYLPHENYLALANYLLYSYL GLYCYLALANYL DEXTRO GLYCYLLYSYLTHREONYLVALYLLEUCYLHISTIDYLTHREONYLALANYLLEUCYLLYSYLALANYLISOLEUCYL SERYLSERINAMIDE; N ALPHA ACETYLLYSYLTRYPTOPHYLLYSYLSERYLPHENYLALANYLLEUCYLLYSYLTHREONYLPHENYLALANYLLYSYL GLYCYLALANYLGLYCYLLYSYLTHREONYLVALYLLEUCYLHISTIDYLTHREONYLALANYLLEUCYLLYSYL ALANYLISOLEUCYLSERYLSERINAMIDE; N ALPHA ACETYLLYSYLTRYPTOPHYLLYSYLSERYLPHENYLALANYLLEUCYLLYSYLTHREONYLPHENYLALANYLLYSYL LEUCYLALANYL DEXTRO LEUCYLLYSYLTHREONYLVALYLLEUCYLHISTIDYLTHREONYLALANYLLEUCYLLYSYLALANYLISOLEUCYL SERYLSERINAMIDE; N ALPHA ACETYLLYSYLTRYPTOPHYLLYSYLSERYLPHENYLALANYLLEUCYLLYSYLTHREONYLPHENYLALANYLLYSYL LEUCYLALANYLLEUCYLLYSYLTHREONYLVALYLLEUCYLHISTIDYLTHREONYLALANYLLEUCYLLYSYL ALANYLISOLEUCYLSERYLSERINAMIDE; N ALPHA ACETYLLYSYLTRYPTOPHYLLYSYLSERYLPHENYLALANYLLEUCYLLYSYLTHREONYLPHENYLALANYLLYSYL LYSYLALANYL DEXTRO LYSYLLYSYLTHREONYLVALYLLEUCYLHISTIDYLTHREONYLALANYLLEUCYLLYSYLALANYLISOLEUCYL SERYLSERINAMIDE; N ALPHA ACETYLLYSYLTRYPTOPHYLLYSYLSERYLPHENYLALANYLLEUCYLLYSYLTHREONYLPHENYLALANYLLYSYL LYSYLALANYLLYSYLLYSYLTHREONYLVALYLLEUCYLHISTIDYLTHREONYLALANYLLEUCYLLYSYLALANYL ISOLEUCYLSERYLSERINAMIDE; N ALPHA ACETYLLYSYLTRYPTOPHYLLYSYLSERYLPHENYLALANYLLEUCYLLYSYLTHREONYLPHENYLALANYLLYSYL SERYLALANYL DEXTRO ALANYLLYSYLTHREONYLVALYLLEUCYLHISTIDYLTHREONYLALANYLLEUCYLLYSYLALANYLISOLEUCYL SERYLSERINAMIDE; N ALPHA ACETYLLYSYLTRYPTOPHYLLYSYLSERYLPHENYLALANYLLEUCYLLYSYLTHREONYLPHENYLALANYLLYSYL SERYLALANYLALANYLLYSYLTHREONYLVALYLLEUCYLHISTIDYLTHREONYLALANYLLEUCYLLYSYL ALANYLISOLEUCYLSERYLSERINAMIDE; N ALPHA ACETYLLYSYLTRYPTOPHYLLYSYLSERYLPHENYLALANYLLEUCYLLYSYLTHREONYLPHENYLALANYLLYSYL VALYLALANYL DEXTRO SERYLLYSYLTHREONYLVALYLLEUCYLHISTIDYLTHREONYLALANYLLEUCYLLYSYLALANYLISOLEUCYL SERYLSERINAMIDE; N ALPHA ACETYLLYSYLTRYPTOPHYLLYSYLSERYLPHENYLALANYLLEUCYLLYSYLTHREONYLPHENYLALANYLLYSYL VALYLALANYLSERYLLYSYLTHREONYLVALYLLEUCYLHISTIDYLTHREONYLALANYLLEUCYLLYSYLALANYL ISOLEUCYLSERYLSERINAMIDE; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIMICROBIAL ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; CORRELATION ANALYSIS; DIASTEREOISOMER; DRUG SYNTHESIS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HEMOLYSIS; HUMAN; HUMAN CELL; HYDROPHILICITY; HYDROPHOBICITY; PARAMETER; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TEMPERATURE DEPENDENCE;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIRCULAR DICHROISM; DRUG DESIGN; ERYTHROCYTES; ESCHERICHIA COLI; GRAM-POSITIVE BACTERIA; HEMOLYSIS; HUMANS; KINETICS; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN BINDING; PROTEIN DENATURATION; PROTEIN STRUCTURE, SECONDARY; STEREOISOMERISM; TEMPERATURE;

EID: 16844373772     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M413406200     Document Type: Article

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