Cationic spacer arm design strategy for control of antimicrobial activity and conformation of amphiphilic methacrylate random copolymers

Biomacromolecules

Volumn 13, Issue 5, 2012, Pages 1632-1641

  Palermo, Edmund F ^a   Vemparala, Satyavani ^c   Kuroda, Kenichi ^a,b  

^a UNIVERSITY OF MICHIGAN SCHOOL OF DENTISTRY   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c INSTITUTE OF MATHEMATICAL SCIENCES   (India)

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIUM GROUPS; AMPHIPHILIC CONFORMATIONS; AMPHIPHILICS; ANTI-MICROBIAL ACTIVITY; ANTIMICROBIAL POTENCY; CHAIN CONFORMATIONS; CO-MONOMER; COMONOMERS; DESIGN STRATEGIES; ETHYL METHACRYLATES; ETHYLMETHACRYLATE; GRAM-NEGATIVE BACTERIA; HEMOLYTIC ACTIVITY; HYDROPHOBIC MEMBRANE; MAGNITUDE ENHANCEMENT; MEMBRANE SURFACE; MEMBRANE-BOUND; MOLECULAR CONFORMATION; MOLECULAR DYNAMICS SIMULATIONS; NON-POLAR; POLYMER BACKBONES; POLYMER CONFORMATION; RANDOM COPOLYMER; SIDE-CHAINS; SPACER ARMS;

AMMONIUM COMPOUNDS; BLOOD; HYDROPHOBICITY; MICROORGANISMS; MOLECULAR DYNAMICS;

COPOLYMERS;

2 AMINOETHYLENE; 2 HYDROXYETHYL METHACRYLATE; 4 AMINOBUTYLENE; 6 AMINOHEXYLENE; AMMONIA; AMPHIPHILIC METHACRYLATE RANDOM COPOLYMER; AMPHOPHILE; CATIONIC SPACER; COPOLYMER; HEXYLENE GLYCOL; INTERNAL TRANSCRIBED SPACER; LIPID PHOSPHATE; METHACRYLIC ACID; PHOSPHOLIPID DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL KINETICS; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG CONFORMATION; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HEMOLYSIS; HYDROPHOBICITY; LIPID BILAYER; MEMBRANE BINDING; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; SURFACE PROPERTY;

ANTI-BACTERIAL AGENTS; CATIONS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ESCHERICHIA COLI; HEMOLYSIS; HUMANS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR DYNAMICS SIMULATION; POLYMETHACRYLIC ACIDS; STAPHYLOCOCCUS AUREUS; SURFACE-ACTIVE AGENTS;

NEGIBACTERIA; POSIBACTERIA;

EID: 84861121216     PISSN: 15257797     EISSN: 15264602     Source Type: Journal    
DOI: 10.1021/bm300342u     Document Type: Article

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