Interplay among folding, sequence, and lipophilicity in the antibacterial and hemolytic activities of α/β-peptides

Journal of the American Chemical Society

Volumn 129, Issue 2, 2007, Pages 417-428

  Schmitt, Margaret A ^a   Weisblum, Bernard ^a   Gellman, Samuel H ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; CELLS; MOLECULAR DYNAMICS; OLIGOMERS; POSITIVE IONS; TOXICITY;

EUKARYOTIC CELLS; HEMOLYTIC ACTIVITIES; HOST DEFENSE PEPTIDES; LIPOPHILICITY;

AMINO ACIDS;

PEPTIDE DERIVATIVE;

ALPHA HELIX; AMINO ACID SEQUENCE; ANTIBACTERIAL ACTIVITY; ARTICLE; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; HEMOLYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIPOPHILICITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN STRUCTURE; SEQUENCE ANALYSIS;

ANTI-BACTERIAL AGENTS; BACILLUS SUBTILIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIRCULAR DICHROISM; ENTEROCOCCUS FAECIUM; ERYTHROCYTES; ESCHERICHIA COLI; HEMOLYSIS; HUMANS; HYDROPHOBICITY; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; PEPTIDE HYDROLASES; PEPTIDES; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; SENSITIVITY AND SPECIFICITY; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33846251959     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0666553     Document Type: Article

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