Mechanism of a prototypical synthetic membrane-active antimicrobial: Efficient hole-punching via interaction with negative intrinsic curvature lipids

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 52, 2008, Pages 20595-20600

  Yang, Lihua ^a,d   Gordon, Vernita D ^a   Trinkle, Dallas R ^a   Schmidt, Nathan W ^a   Davis, Matthew A ^a   DeVries, Clarabelle ^a   Som, Abhigyan ^c   Cronan Jr , John E ^b   Tew, Gregory N ^c   Wong, Gerard C L ^a  

^a University of Illinois at Urbana Champaign   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^c UNIVERSITY OF MASSACHUSETTS   (United States)

^d SICHUAN UNIVERSITY   (China)

Author keywords

Antibiotic resistant bacteria; Host defense peptides; Innate immunity; Protein membrane interactions

Indexed keywords

ANTIINFECTIVE AGENT; HEXANOL; LIPID; PHENYLENE ETHYNELENE; PHOSPHATIDYLETHANOLAMINE; TOBRAMYCIN; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL MEMBRANE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; MEMBRANE PERMEABILITY; NONHUMAN; PRIORITY JOURNAL;

ALKYNES; ANTI-INFECTIVE AGENTS; BIOMIMETIC MATERIALS; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; ESCHERICHIA COLI; ETHERS; MEMBRANES, ARTIFICIAL; PEPTIDES; PHOSPHATIDYLETHANOLAMINES;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; EUKARYOTA;

EID: 58549115686     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0806456105     Document Type: Article

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