Link between vitamin D and airway remodeling

Journal of Asthma and Allergy

Volumn , Issue 7, 2014, Pages 23-30

  Berraies, Anissa ^a   Hamzaoui, Kamel ^a   Hamzaoui, Agnes ^a  

^a ABDERRAHMAN MAMI HOSPITAL   (Tunisia)

Author keywords

Airway remodeling; Airway smooth muscle; Asthma; Supplementation; Vitamin D

Indexed keywords

BECLOMETASONE; BUDESONIDE; CICLESONIDE; CORTICOSTEROID DERIVATIVE; FLUTICASONE; SALBUTAMOL;

ADOLESCENT; ADULT; AGE; ASTHMA; BREATH ACTUATED INHALER; CHILD; COHORT ANALYSIS; COMPARATIVE EFFECTIVENESS; CONSULTATION; CONTROLLED STUDY; CORTICOSTEROID THERAPY; COST EFFECTIVENESS ANALYSIS; DISEASE CONTROL; DISEASE EXACERBATION; DOSE RESPONSE; DRY POWDER INHALER; FEMALE; HEALTH CARE COST; HUMAN; MAJOR CLINICAL STUDY; MALE; METERED DOSE INHALER; RESPIRATORY THERAPEUTIC DEVICE; REVIEW; SEX DIFFERENCE; TREATMENT OUTCOME;

EID: 84903600442     PISSN: 11786965     EISSN: None     Source Type: Journal    
DOI: 10.2147/JAA.S46944     Document Type: Review

References (93)

1. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357:266-281.
2. Nagpal S, Na S, Rathnachalam R. Noncalcemic actions of vitamin D receptor ligands. Endocr Rev. 2005;26:662-687.
3. Paul G, Brehm JM, Alcorn JF, Holguín F, Aujla SJ, Celedón JC. Vitamin D and asthma. Am J Respir Crit Care Med. 2012;185:124-132.
4. Poon AH, Mahboub B, Hamid Q. Vitamin D deficiency and severe asthma. Pharmacol Ther. 2013;140:148-155.
5. Camargo CA Jr, Ingham T, Wickens K, etal. Cord-blood 25-hydroxyvitamin D levels and risk of respiratory infection, wheezing, and asthma. New Zealand Asthma and Allergy Cohort Study Group Pediatrics. 2011;127:e180-e187.
6. Freishtat RJ, Iqbal SF, Pillai DK, etal. High prevalence of vitamin D deficiency among inner-city African American youth with asthma in Washington, DC. J Pediatr. 2010;156:948-952.
7. Bener A, Ehlayel MS, Tulic MK, Hamid Q. Vitamin D deficiency as a strong predictor of asthma in children. Int Arch Allergy Immunol. 2012;157:168-175.
8. Alyasin S, Momen T, Kashef S, Alipour A, Amin R. The relationship between serum 25 hydroxyvitamin D levels and asthma in children. Allergy Asthma Immunol Res. 2011;3:251-255.
9. Chinellato I, Piazza M, Sandri M, etal. Serum vitamin D levels and exercise-induced bronchoconstriction in children with asthma. Eur Respir J. 2011;37:1366-1370.
10. Chinellato I, Piazza M, Sandri M, Peroni D, Piacentini G, Boner AL. Vitamin D serum levels and markers of asthma control in Italian children. J Pediatr. 2011;158:437-441.
11. Burns JS, Dockery DW, Neas LM, etal. Low dietary nutrient intakes and respiratory health in adolescents. Chest. 2007;132:238-245.
12. Black PN, Scragg R. Relationship between serum 25-hydroxyvitamin D and pulmonary function in the third national health and nutrition examination survey. Chest. 2005;128:3792-3798.
13. Sutherland ER, Goleva E, Jackson LP, Stevens AD, Leung DY. Vitamin D levels, lung function, steroid response in adult asthma. Am J Respir Crit Care Med. 2010;181:699-704.
14. Li F, Peng M, Jiang L, etal. Vitamin D deficiency is associated with decreased lung function in Chinese adults with asthma. Respiration. 2011;81:469-475.
15. Searing DA, Zhang Y, Murphy JR, Hauk PJ, Goleva E, Leung DY. Decreased serum vitamin D levels in children with asthma are associated with increased corticosteroid use. J Allergy Clin Immunol. 2010;125: 955-1000.
16. Brehm JM, Celedòn JC, Soto-Quiros ME, etal. Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica. Am J Respir Crit Care Med. 2009;179:765-771.
17. Brehm JM, Schuemann B, Fuhlbrigge AL, etal. Serum vitamin D levels and severe asthma exacerbations in the childhood asthma management program study. J Allergy Clin Immunol. 2010;126:52-58.
18. Majak P, Olszowiec-Chlebna M, Smejda K, Stelmach I. Vitamin D supplementation in children may prevent asthma exacerbation triggered by acute respiratory infection. J Allergy Clin Immunol. 2011;127: 1294-1296.
19. Devereux G, Wilson A, Avenell A, McNeill G, Fraser WD. A case-control study of vitamin D status and asthma in adults. Allergy. 2010;65: 666-667.
20. Hughes AM, Lucas RM, Ponsonby AL, etal. The role of latitude, ultraviolet radiation exposure and vitamin D in childhood asthma and hayfever: an Australian multicenter study. Pediatr Allergy Immunol. 2011;22:327-333.
21. Huang H, Porpodis K, Zarogoulidis P, etal. Vitamin D in asthma and future perspectives. Drug Des Devel Ther. 2013;7:1003-1013.
22. Raby BA, Lazarus R, Silverman EK, etal. Association of vitamin D receptor gene polymorphisms with childhood and adult asthma. Am J Respir Crit Care Med. 2004;170:1057-1065.
23. Poon AH, Laprise C, Lemire M, etal. Association of vitamin D receptor genetic variants with susceptibility to asthma and atopy. Am J Respir Crit Care Med. 2004;170:967-973.
24. Maalmi H, Sassi FH, Berraies A, Ammar J, Hamzaoui K, Hamzaoui A. Association of vitamin D receptor gene polymorphisms with susceptibility to asthma in Tunisian children: a case control study. Hum Immunol. 2013;74:234-240.
25. Bosse Y, Maghni K, Hudson TJ. 1α,25-dihydroxy-vitamin D3 stimulation of bronchial smooth muscle cells induces autocrine, contractility, and remodeling processes. Physiol Genomics. 2007;29:161-168.
26. Reardon BJ, Hansen JG, Crystal RG, etal. Vitamin D-responsive SGPP2 variants associated with lung cell expression and lung function. BMC Med Genet. 2013;14:122.
27. Hewison M. Vitamin D and the intracrinology of innate immunity. Mol Cell Endocrinol. 2010;321:103-111.
28. Provvedini DM, Tsoukas CD, Deftos LJ, Manolagas SC. 1,25 dihydroxyvitamin D3 receptors in human leukocytes. Science. 1983;221: 1181-1183.
29. Wang Y, Zhu J, DeLuca HF. Where is the vitamin D receptor? Arch Biochem Biophys. 2012;523:123-133.
30. Baeke F, Korf H, Overbergh L, etal. Human T lymphocytes are direct targets of 1,25-dihydroxyvitamin D3 in the immune system. J Steroid Biochem Mol Biol. 2010;121:221-227.
31. Wittke A, Weaver V, Mahon BD, August A, Cantorna MT. Vitamin D receptor-deficient mice fail to develop experimental allergic asthma. J Immunol. 2004;173:3432-3436.
32. Urry Z, Chambers ES, Xystrakis E, etal. The role of 1α,25-dihydroxyvitamin D3 and cytokines in the promotion of distinct Foxp3+ and IL-10+ CD4+ T cells. Eur J Immunol. 2012;42:2697-2708.
33. Gregori S, Casorati M, Amuchastegui S, Smiroldo S, Davalli AM, Adorini L. Regulatory T cells induced by 1 alpha,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance. J Immunol. 2001;167:1945-1953.
34. Maalmi H, Berraies A, Tangour E, etal. The impact of vitamin D deficiency on immune T cells in asthmatic children: a case-control study. J Asthma Allergy. 2012;5:11-19.
35. Tang J, Zhou R, Luger D, etal. Calcitriol suppresses antiretinal autoimmunity through inhibitory effects on the Th17 effector response. J Immunol. 2009;182:4624-4632.
36. Daniel C, Sartory NA, Zahn N, etal. Immune modulatory treatment of trinitrobenzene sulfonic acid colitis with calcitriol is associated with a change of a T helper (Th) 1/Th17 to a Th2 and regulatory T cell profile. J Pharmacol Exp Ther. 2008;324:23-33.
37. Nanzer AM, Chambers ES, Ryanna K, etal. Enhanced production of IL-17A in patients with severe asthma is inhibited by 1α,25-dihydroxyvitamin D3 in a glucocorticoid-independent fashion. J Allergy Clin Immunol. 2013;132:297-304.
38. Wu AC, Tantisira K, Li L, Fuhlbrigge AL, Weiss ST, Litonjua A; Childhood Asthma Management Program Research Group. Effect of vitamin D and inhaled corticosteroid treatment on lung function in children. Am J Respir Crit Care Med. 2012;186:508-513.
39. Beard JA, Bearden A, Striker R. Vitamin D and the anti-viral state. J Clin Virol. 2011;50:194-200.
40. Prakash YS. Airway smooth muscle in airway reactivity and remodeling: what have we learned? Am J Physiol Lung Cell Mol Physiol. 2013;305: L912-L933.
41. Yamauchi K, Inoue H. Airway remodeling in asthma and irreversible airflow limitation-ECM deposition in airway and possible therapy for remodeling. Allergol Int. 2007;56:321-329.
42. Proud D. Role of rhinovirus infections in asthma. Asian Pac J Allergy Immunol. 2011;29:201-208.
43. Agrawal T, Gupta GK, Agrawal DK. Vitamin D supplementation reduces airway hyperresponsiveness and allergic airway inflammation in a murine model. Clin Exp Allergy. 2013;43:672-683.
44. Lai G, Wu C, Hong J, Song Y. 1,25-dihydroxyvitamin D(3) (1,25-(OH)(2)D(3) attenuates airway remodeling in a murine model of chronic asthma. J Asthma. 2013;50:133-140.
45. Cao Y, Zeng D, Song Q, etal. The effects of antisense interleukin-4 gene transferred by recombinant adeno-associated virus vector on the airway remodeling in allergic rats. J Asthma. 2010;47:951-958.
46. Dimeloe S, Nanzer A, Ryanna K, Hawrylowicz C. Regulatory T cells, inflammation and the allergic response-the role of glucocorticoids and vitamin D. J Steroid Biochem Mol Biol. 2010;120:86-95.
47. Ramirez AM, Wongtrakool C, Welch T, Steinmeyer A, Zügel U, Roman J. Vitamin D inhibition of pro-fibrotic effects of transforming growth factor beta1 in lung fibroblasts and epithelial cells. J Steroid Biochem Mol Biol. 2010;118:142-150.
48. Yang ZC, Yi MJ, Ran N, etal. Transforming growth factor-β1 induces bronchial epithelial cells to mesenchymal transition by activating the Snail pathway and promotes airway remodeling in asthma. Mol Med Rep. 2013;8:1663-1668.
49. Sabatini F, Petecchia L, Usai C, etal. Pharmacological modulation of the bradykinin-induced differentiation of human lung fibroblasts: effects of budesonide and formoterol. J Asthma. 2012;49:1004-1011.
50. Sundar IK, Hwang JW, Wu S, Sun J, Rahman I. Deletion of vitamin D receptor leads to premature emphysema/COPD by increased matrix metalloproteinases and lymphoid aggregates formation. Biochem Biophys Res Commun. 2011;406:127-133.
51. Anand SP, Selvaraj P. Effect of 1, 25 dihydroxyvitamin D(3) on matrix metalloproteinases MMP-7, MMP-9 and the inhibitor TIMP-1 in pulmonary tuberculosis. Clin Immunol. 2009;133:126-131.
52. Meephansan J, Komine M, Tsuda H, Ohtsuki M. Suppressive effect of calcipotriol on the induction of matrix metalloproteinase (MMP)-9 and MMP-13 in a human squamous cell carcinoma cell line. Clin Exp Dermatol. 2012;37:889-896.
53. Johnson LA, Sauder KL, Rodansky ES, Simpson RU, Higgins PD. CARD-024, a vitamin D analog, attenuates the pro-fibrotic response to substrate stiffness in colonic myofibroblasts. Exp Mol Pathol. 2012;93: 91-98.
54. Bahar-Shany K, Ravid A, Koren R. Upregulation of MMP-9 production by TNF alpha in keratinocytes and its attenuation by vitamin D. J Cell Physiol. 2010;222:729-737.
55. Chen Y, Zhang J, Ge X, etal. Vitamin D receptor inhibits nuclear factor κB activation by interacting with IκB kinase β protein. J Biol Chem. 2013;288:19450-19458.
56. Bentley JK, Hershenson MB. Airway smooth muscle growth in asthma: proliferation, hypertrophy, and migration. Proc Am Thorac Soc. 2008;5: 89-96.
57. Bergeron C, Boulet LP. Structural changes in airway diseases: characteristics, mechanisms, consequences, and pharmacologic modulation. Chest. 2006;129:1068-1087.
58. Goleva E, Hauk PJ, Boguniewicz J, etal. Airway remodeling and lack of bronchodilator response in steroid-resistant asthma. J Allergy Clin Immunol. 2007;120:1065-1072.
59. Tsurikisawa N, Oshikata C, Tsuburai T, etal. Bronchial reactivity to histamine is correlated with airway remodeling in adults with moderate to severe asthma. J Asthma. 2010;47:841-848.
60. Iqbal SF, Freishtat RJ. Mechanism of action of vitamin D in the asthmatic lung. J Investig Med. 2011;59:1200-1202.
61. Berndt A, Savage HS, Stearns TM, Paigen B. Genetic analysis of lung functioning inbred mice suggests vitamin D receptor as a candidate gene. Mol Genet Genomics. 2011;286:237-246.
62. Damera G, Fogle HW, Lim P, etal. Vitamin D inhibits growth of human airway smooth muscle cells through growth factor-induced phosphorylation of retinoblastoma protein and checkpoint kinase 1. Br J Pharmacol. 2009;158:1429-1441.
63. Gupta A, Sjoukes A, Richards D, etal. Relationship between serum vitamin D, disease severity, and airway remodeling in children with asthma. Am J Respir Crit Care Med. 2011;184:1342-1349.
64. Liu X, Nelson A, Wang X, etal. Vitamin D modulates PGE2 synthesis and degradation in human lung fibroblasts. Am J Respir Cell Mol Biol. 2014;50:40-50.
65. Wark PA, Tooze M, Powell H, Parsons K. Viral and bacterial infection in acute asthma and chronic obstructive pulmonary disease increases the risk of readmission. Respirology. 2013;18:996-1002.
66. Kuo C, Lim S, King NJ, etal. Rhinovirus infection induces extracellular matrix protein deposition in asthmatic and nonasthmatic airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2011;300: L951-L957.
67. Skevaki CL, Psarras S, Volonaki E, etal. Rhinovirus-induced basic fibroblast growth factor release mediates airway remodeling features. Clin Transl Allergy. 2012;2:14.
68. Brockman-Schneider RA, Pickles RJ, Gern JE. Effects of vitamin D on airway epithelial cell morphology and rhinovirus replication. PLoS One. 2014;9:e86755.
69. Khare D, Godbole NM, Pawar SD, etal. Calcitriol [1, 25(OH)2 D3] pre-and post-treatment suppresses inflammatory response to influenza A (H1N1) infection in human lung A549 epithelial cells. Eur J Nutr. 2013;52:1405-1415.
70. Vandamme D, Landuyt B, Luyten W, Schoofs L. A comprehensive summary of LL-37, the factotum human cathelicidin peptide. Cell Immunol. 2012;280:22-35.
71. Makinde T, Murphy RF, Agrawal DK. Immunomodulatory role of vascular endothelial growth factor and angiopoietin-1 in airway remodeling. Curr Mol Med. 2006;6:831-841.
72. Lee KY, Lee KS, Park SJ, etal. Clinical significance of plasma and serum vascular endothelial growth factor in asthma. J Asthma. 2008;45: 735-739.
73. Iwanaga K, Elliott MS, Vedal S, Debley JS. Urban particulate matter induces pro-remodeling factors by airway epithelial cells from healthy and asthmatic children. Inhal Toxicol. 2013;25:653-660.
74. Kim SH, Choi GS, Nam YH, etal. Role of vitamin D-binding protein in isocyanate-induced occupational asthma. Exp Mol Med. 2012;44: 319-329.
75. Grundmann M, Haidar M, Placzko S, etal. Vitamin D improves the angiogenic properties of endothelial progenitor cells. Am J Physiol Cell Physiol. 2012;303:C954-C962.
76. Wu J, Dong F, Wang RA, etal. Central role of cellular senescence in TSLP-induced airway remodeling in asthma. PLoS One. 2013;8:e77795.
77. Shen M, Luo Y, Niu Y, etal. 1,25(OH)2D deficiency induces temporomandibular joint osteoarthritis via secretion of senescence-associated inflammatory cytokines. Bone. 2013;55:400-409.
78. Gaultier C, Harf A, Balmain N, Cuisinier-Gleizes P, Mathieu H. Lung mechanics in rachitic rats. Am Rev Respir Dis. 1984;130:1108-1110.
79. Kang JY, Kim JW, Kim JS, etal. Inhibitory effects of anti-immunoglobulin E antibodies on airway remodeling in a murine model of chronic asthma. J Asthma. 2010;47:374-380.
80. Yadav M, Mittal K. Effect of vitamin D supplementation on moderate to severe bronchial asthma. Indian J Pediatr. November 6, 2013. [Epub ahead of print].
81. Baris S, Kiykim A, Ozen A, Tulunay A, Karakoc-Aydiner E, Barlan IB. Vitamin D as an adjunct to subcutaneous allergen immunotherapy in asthmatic children sensitized to house dust mite. Allergy. 2014;69: 246-253.
82. Litonjua AA. Vitamin D deficiency as a risk factor for childhood allergic disease and asthma. Curr Opin Allergy Clin Immunol. 2012;12: 179-185.
83. Camargo CA Jr, Rifas-Shiman SL, Litonjua AA, etal. Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age. Am J Clin Nutr. 2007;85:788-795.
84. Devereux G, Litonjua AA, Turner SW, etal. Maternal vitamin D intake during pregnancy and early childhood wheezing. Am J Clin Nutr. 2007;85:853-859.
85. Erkkola M, Kaila M, Nwaru BI, etal. Maternal vitamin D intake during pregnancy is inversely associated with asthma and allergic rhinitis in 5-year-old children. Clin Exp Allergy. 2009;39:875-882.
86. Gale CR, Robinson SM, Harvey NC, etal. Maternal vitamin D status during pregnancy and child outcomes. Eur J Clin Nutr. 2008;62: 68-77.
87. Wjst M, Dold S. Genes, factor X, and allergens: what causes allergic diseases? Allergy. 1999;54:757-759.
88. ClinicalTrials. gov. Maternal Vitamin D Supplementation to Prevent Childhood Asthma (VDAART). Available from: http://clinicaltrials.gov/ct2/show/NCT00920621. Accessed February 14, 2014.
89. Van Oeffelen AA, Bekkers MB, Smit HA, etal. Serum micronutrient concentrations and childhood asthma: the PIAMA birth cohort study. Pediatr Allergy Immunol. 2011;22:784-793.
90. Goldring ST, Griffiths CJ, Martineau AR, etal. Prenatal vitamin D supplementation and child respiratory health: a randomised controlled trial. PLoS One. 2013;8:e66627.
91. Xystrakis E, Kusumakar S, Boswell S, etal. Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients. J Clin Invest. 2006;116:146-155.
92. Gunville CF, Mourani PM, Ginde AA. The role of vitamin D in prevention and treatment of infection. Inflamm Allergy Drug Targets. 2013;12:239-245.
93. Laaksi I, Ruohola JP, Mattila V, Auvinen A, Ylikomi T, Pihlajamäki H. Vitamin D supplementation for the prevention of acute respiratory tract infection: a randomized, double-blinded trial among young Finnish men. J Infect Dis. 2010;202:809-814.