Pharmacological modulation of the bradykinin-induced differentiation of human lung fibroblasts: Effects of budesonide and formoterol

Journal of Asthma

Volumn 49, Issue 10, 2012, Pages 1004-1011

  Sabatini, Federica ^a   Petecchia, Loredana ^a   Usai, Cesare ^b   Silvestri, Michela ^a   Rossi, Giovanni A ^a   Miller Larsson, Anna ^c   Ricciardolo, Fabio L M ^d  

^a G GASLINI INSTITUTE   (Italy)

^b CNR   (Italy)

^c ASTRAZENECA R AND D   (Sweden)

^d UNIVERSITY OF TURIN   (Italy)

Author keywords

smooth muscle actin ( SMA); Bradykinin B2 receptor (B2R); Human lung fibroblasts; Mitogen activated protein kinases (MAPKs)

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BRADYKININ; BRADYKININ B2 RECEPTOR; BUDESONIDE; CALCIUM ION; FORMOTEROL; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; TRANSCRIPTION FACTOR RELA;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CELL DIFFERENTIATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME PHOSPHORYLATION; FETUS; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; LUNG FIBROBLAST; MYOFIBROBLAST; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

BRADYKININ; BRONCHODILATOR AGENTS; BUDESONIDE; CALCIUM; CELL DIFFERENTIATION; CELLS, CULTURED; CO-REPRESSOR PROTEINS; DRUG THERAPY, COMBINATION; ETHANOLAMINES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; HUMANS; LUNG; MYOFIBROBLASTS; NUCLEAR PROTEINS; RECEPTOR, BRADYKININ B2; SIGNAL TRANSDUCTION;

EID: 84874272347     PISSN: 02770903     EISSN: 15324303     Source Type: Journal    
DOI: 10.3109/02770903.2012.729633     Document Type: Article

References (35)

1. Kaplan AP, Joseph K, Silverberg M. Pathways for bradykinin formation and inflammatory disease. J Allergy Clin Immunol 2002; 109:195-209 (Pubitemid 34158283)
2. Leeb-Lundberg LM, Marceau F, Muller-Esterl W, Pettibone DJ, Zuraw BL. International Union of Pharmacology. XLV. Classification of the kinin receptor family: From molecular mechanisms to pathophysiological consequences. Pharmacol Rev 2005; 57:27-77
3. Proud D. The kinin system in rhinitis and asthma. Clin Rev Allergy Immunol 1998; 16,(4):351-364 (Pubitemid 29056350)
4. Ricciardolo FLM, Nadel JA, Yoshihara S, Geppetti P. Evidence for reduction of bradykinin-induced bronchoconstriction in guinea-pigs by release of nitric oxide. Br J Pharmacol 1994; 113:1147-1152 (Pubitemid 24364391)
5. Ricciardolo FLM, Nadel JA, Graf PD, Bertrand C, Yoshihara S, Geppetti P. Role of kinins in anaphylactic-induced bronchoconstriction mediated by tachykinins in guinea-pigs. Br J Pharmacol 1994; 113:508-512 (Pubitemid 24310750)
6. Mio T, Liu X, ToewsM,AdachiY, Romberger D, SpurzemJ, Rennard SI. Bradykinin augments fibroblast-mediated contraction of released collagen gels. Am J Physiol Lung Cell Mol Physiol 2001; 281,(1):L164-L171
7. Hayashi R, Yamashita N, Matsui S, Fujita T, Araya J, Sassa K, Arai N, Yoshida Y, Kashii T, Maruyama M, Sugiyama E, Kobayashi M. Bradykinin stimulates IL-6 and IL-8 production by human lung fibroblasts through ERK- and p38 MAPK-dependent mechanisms. Eur Respir J 2000; 16,(3):452-458
8. Vancheri C, Gili E, Failla M, Mastruzzo C, Salinaro E, Lofurno D, Pistorio MP, La Rosa C, Caruso M, Crimi N. Bradykinin differentiates human lung fibroblasts to a myofibroblast phenotype via the B2 receptor. J Allergy Clin Immunol 2005; 116,(6):1242-1248 (Pubitemid 41740930)
9. Holgate ST, Arshad HS, Roberts GC, Howarth PH, Thurner P, Davies DE. A new look at the pathogenesis of asthma. Clin Sci 2010; 118:439-450
10. Boxall C, Holgate ST, Davies DE. The contribution of trasforming growth factor-β and epidermal growth factor signalling to airway remodelling in chronic asthma. Eur Respir J 2006; 27:208-229 (Pubitemid 43092684)
11. Chetty A, Cao GJ, Nielsen HC. Insulin-like Growth Factor-I signaling mechanisms, type I collagen and alpha smooth muscle actin in human fetal lung fibroblasts. Pediatr Res 2006; 60,(4):389-394 (Pubitemid 44427588)
12. Petecchia L, Sabatini F, Usai C, Carnevali S, Ognibene M, Vanni C, Eva A, Fabbri LM, Rossi GA, Ricciardolo FL. Mechanisms of bradykinininduced contraction in human fetal lung fibroblasts. Eur Respir J 2010; 36,(3):655-664
13. Brechter AB, Persson E, Lundgren I, Lerner UH. Kinin B1 and B2 receptor expression in osteoblasts and fibroblasts is enhanced by interleukin-1 and tumour necrosis factor-alpha. Effects dependent on activation of NF-kappaB and MAP kinases. Bone 2008; 43,(1):72-83
14. Edwards SJ, von Maltzahn R, Naya IP, Harrison T. Budesonide/formoterol for maintenance and reliever therapy of asthma: A meta analysis of randomised controlled trials. Int J Clin Pract 2010; 64,(5):619-627
15. Kelly MM, O'Connor TM, Leigh R, Otis J, Gwozd C, Gauvreau GM, Gauldie J, O'Byrne PM. Effects of budesonide and formoterol on allergen-induced airway responses, inflammation, and airway remodeling in asthma. J Allergy Clin Immunol 2010; 125,(2):349-56.e13
16. Capraz F, Kunter E, Cermik H, Ilvan A, Pocan S. The effect of inhaled budesonide and formoterol on bronchial remodeling and HRCT features in young asthmatics. Lung 2007; 185,(2):89-96 (Pubitemid 46571878)
17. Battaglia M, Pozzi D, Grimaldi S, Parasassi T. Hoechst 33258 staining for detecting mycoplasma contamination in cell cultures: A method for reducing fluorescence photobleaching. Biotech Histochem 1994; 69,(3):152-156 (Pubitemid 24163537)
18. Aarbiou J, Verhoosel RM, Van Wetering S, De Boer WI, Van Krieken JH, Litvinov SV, Rabe KF, Hiemstra PS. Neutrophil defensins enhance lung epithelial wound closure and mucin gene expression in vitro. Am J Respir Cell Mol Biol 2004; 30,(2):193-201 (Pubitemid 38147204)
19. Kim J, Jain D, Tliba O, Yang B, Jester WJ, Panettieri RJ, Amrani Y, Puré E. TGF-beta potentiates airway smooth muscle responsiveness to bradykinin. Am J Physiol Lung Cell Mol Physiol 2005; 289,(4):L511-L520 (Pubitemid 41361660)
20. Pat B, Yang T, Kong C, Watters D, Johnson DW, Gobe G. Activation of ERK in renal fibrosis after unilateral ureteral obstruction: Modulation by antioxidants. Kidney Int 2005; 67,(3):931-943 (Pubitemid 41623317)
21. Brandenburg LO, Kipp M, Lucius R, Pufe T, Wruck CJ. Sulforaphane suppresses LPS-induced inflammation in primary rat microglia. Inflamm Res 2010; 59,(6):443-450
22. Van den Bosch JM, Westermann CJ, Aumann J, Edsbäcker S, Tönnesson M, Selroos O. Relationship between lung tissue and blood plasma concentrations of inhaled budesonide. Biopharm Drug Dispos 1993; 14,(5):455-459 (Pubitemid 23186347)
23. Campestrini J, Lecaillon JB, Godbillon J. Automated and sensitive method for the determination of formoterol in human plasma by highperformance liquid chromatography and electrochemical detection. J Chromatogr B Biomed Sci Appl 1997; 704,(1-2):221-229 (Pubitemid 28021908)
24. Brewster CE, Howarth PH, Djukanovic R, Wilson J, Holgate ST, Roche WR. Myofibroblasts and subepithelial fibrosis in bronchial asthma. Am J Respir Cell Mol Biol 1990; 3,(5):507-511
25. Darby I, Skalli O, Gabbiani G. Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing. Lab Invest 1990; 63,(1):21-29 (Pubitemid 20234670)
26. Hinz B, Celetta G, Tomasek JJ, Gabbiani G, Chaponnier C. Alphasmooth muscle actin expression upregulates fibroblast contractile activity. Mol Biol Cell 2001; 12,(9):2730-2741 (Pubitemid 33051938)
27. Prado GN, Taylor L, Zhou X, Ricupero D, Mierke DF, Polgar P. Mechanisms regulating the expression, self-maintenance, and signalingfunction of the bradykinin B2 and B1 receptors. J Cell Physiol 2002; 193,(3):275-286 (Pubitemid 35265948)
28. Saifudeen Z, Du H, Dipp S, El-Dahr SS. The bradykinin type 2 receptor is a target for p53-mediated transcriptional activation. J Biol Chem 2000; 275,(20):15557-15562 (Pubitemid 30337290)
29. Haddad E, Fox A, Rousell J, Burgess G, McIntyre P, Barnes P, Chung KF. Post-transcriptional regulation of bradykinin B1 and B2 receptor gene expression in human lung fibroblasts by tumor necrosis factoralpha: Modulation by dexamethasone. Mol Pharmacol 2000; 57, (6):1123-1131 (Pubitemid 30354384)
30. Silvestri M, Fregonese L, Sabatini F, Dasic G, Rossi GA. Fluticasone and salmeterol downregulate in vitro, fibroblast proliferation and ICAM-1 or H-CAM expression. Eur Respir J 2001; 18,(1):139-145 (Pubitemid 32717441)
31. Johnson M. Molecular mechanisms of β2-adrenergic receptor function, response, and regulation. J Allergy Clin Immunol 2006; 117: 18-24 (Pubitemid 43017132)
32. Marin Castano ME, Schanstra JP, Hirtz C, Pesquero JB, Pecher C, Girolami J-P, Bascands JL. B2 kinin receptor upregulation by cAMP is associated with BK-induced PGE2 production in rat mesangial cells. . Am J Physiol Renal Physiol 1998; 274:F532-F540
33. Ay B, Iyanoye A, Sieck GC, Prakash YS, Pabelick CM. Cyclic nucleotide regulation of store-operated Ca2 influx in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 2006; 290,(2): L278-L283
34. Gao YD, Zou JJ, Zheng JW, Shang M, Chen X, Geng S, Yang J. Promoting effects of IL-13 on Ca2 release and store-operated Ca2 entry in airway smooth muscle cells. Pulm Pharmacol Ther 2010; 23,(3):182-189
35. Horvath G, Vasas S, Wanner A. Inhaled corticosteroids reduce asthmaassociated airway hyperperfusion through genomic and nongenomic mechanisms. Pulm Pharmacol Ther 2007; 20,(2):157-162 (Pubitemid 44780159)