Urban particulate matter induces pro-remodeling factors by airway epithelial cells from healthy and asthmatic children

Inhalation Toxicology

Volumn 25, Issue 12, 2013, Pages 653-660

  Iwanaga, Kensho ^a   Elliott, Molly S ^b   Vedal, Sverre ^c   Debley, Jason S ^b,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SEATTLE CHILDREN S RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Adolescent; Airway remodeling; Asthma; Child; Epithelial cells; Interleukin 8; Mucin 5AC; Particulate matter; Transforming growth factor 2; Vascular endothelial growth factor

Indexed keywords

BRONCHODILATING AGENT; CORTICOSTEROID; FLUTICASONE; IMMUNOGLOBULIN E; INTERLEUKIN 8; LEUKOTRIENE RECEPTOR BLOCKING AGENT; MUCIN 5AC; TRANSFORMING GROWTH FACTOR BETA2; VASCULOTROPIN;

ADOLESCENT; AIRWAY REMODELING; ALLERGIC RHINITIS; ARTICLE; ASTHMA; ATOPIC DERMATITIS; CELL DIFFERENTIATION; CHILD; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LONG TERM EXPOSURE; LUNG ALVEOLUS EPITHELIUM; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; OXYGEN THERAPY; PARTICULATE MATTER; PHYSICAL CHEMISTRY; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOALLERGOSORBENT TEST; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; SCHOOL CHILD; URBAN AREA; WHEEZING;

ADOLESCENT; AIR POLLUTANTS; AIRWAY REMODELING; ASTHMA; CELLS, CULTURED; CHILD; CITIES; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION; HUMANS; INTERLEUKIN-8; MALE; MUCIN 5AC; PARTICULATE MATTER; TRANSFORMING GROWTH FACTOR BETA2; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84885444612     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.3109/08958378.2013.827283     Document Type: Article

References (63)

1. Aufderheide M, Knebel JW, Ritter D. (2003). Novel approaches for studying pulmonary toxicity in vitro. Toxicol Lett 140-141:205-11. (Pubitemid 36378939)
2. Aufderheide M, Costa DL, Devlin R, et al. (2005). Experimental assessment of the toxicological effects of inhaled complex mixtures on the respiratory system, 23-25 April 2005, Barcelona, Spain.
3. Summary and conclusions of the review committee. Exp Toxicol Pathol 57: 239-43.
4. Bautista MV, Chen Y, Ivanova VS, et al. (2009). IL-8 regulates mucin gene expression at the posttranscriptional level in lung epithelial cells. J Immunol 183:2159-66.
5. Bayram H, Sapsford RJ, Abdelaziz MM, Khair OA. (2001). Effect of ozone and nitrogen dioxide on the release of proinflammatory mediators from bronchial epithelial cells of nonatopic nonasthmatic subjects and atopic asthmatic patients in vitro. J Allergy Clin Immunol 107:287-94. (Pubitemid 32173906)
6. Becker S, Dailey L, Soukup JM, et al. (2005). TLR-2 is involved in airway epithelial cell response to air pollution particles. Toxicol Appl Pharmacol 203:45-52. (Pubitemid 40208365)
7. Bernstein JA, Alexis N, Barnes C, et al. (2004). Health effects of air pollution. J Allergy Clin Immunol 114:1116-23. (Pubitemid 39469153)
8. Berube K, Prytherch Z, Job C, Hughes T. (2010). Human primary bronchial lung cell constructs: the new respiratory models. Toxicology 278:311-18.
9. Boxall C, Holgate ST, Davies DE. (2006). The contribution of transforming growth factor-beta and epidermal growth factor signalling to airway remodelling in chronic asthma. Eur Respir J 27:208-29. (Pubitemid 43092684)
10. Brunekreef B, Annesi-Maesano I, Ayres JG, et al. (2012). Ten principles for clean air. Eur Respir J 39:525-8.
11. Calderon-Garciduenas L, Valencia-Salazar G, Rodriguez-Alcaraz A, et al. (2001). Ultrastructural nasal pathology in children chronically and sequentially exposed to air pollutants. Am J Respir Cell Mol Biol 24:132-8.
12. Chetta A, Zanini A, Foresi A, et al. (2005). Vascular endothelial growth factor up-regulation and bronchial wall remodelling in asthma. Clin Exp Allergy 35:1437-42.
13. Churg A, Brauer M, del Carmen Avila-Casado M, et al. (2003). Chronic exposure to high levels of particulate air pollution and small airway remodeling. Environ Health Perspect 111:714-18. (Pubitemid 36621601)
14. Colbeck I, Lazaridis M. (2010). Aerosols and environmental pollution. Naturwissenschaften 97:117-31.
15. Committee of the Environmental and Occupational Health Assembly of the American Thoracic Society. (1996). Health effects of outdoor air pollution. Am J Respir Crit Care Med 153:3-50.
16. Cooney DJ, Hickey AJ. (2011). Cellular response to the deposition of diesel exhaust particle aerosols onto human lung cells grown at the air-liquid interface by inertial impaction. Toxicol in Vitro 25: 1953-65.
17. Dockery DW, Pope 3rd, CA. (1994). Acute respiratory effects of particulate air pollution. Annu Rev Public Health 15:107-32. (Pubitemid 24178996)
18. Dweik RA, Boggs PB, Erzurum SC, et al. (2011). An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am J Respir Crit Care Med 184: 602-15.
19. Fujii T, Hayashi S, Hogg JC, et al. (2001). Particulate matter induces cytokine expression in human bronchial epithelial cells. Am J Respir Cell Mol Biol 25:265-71. (Pubitemid 32918906)
20. Gauderman WJ, Vora H, McConnell R, et al. (2007). Effect of exposure to traffic on lung development from 10 to 18 years of age: a cohort study. Lancet 369:571-7.
21. Gauderman WJ, Avol E, Gilliland F, et al. (2004). The effect of air pollution on lung development from 10 to 18 years of age. N Engl J Med 351:1057-67. (Pubitemid 39167510)
22. Gras D, Bourdin A, Vachier I, et al. (2012). An ex vivo model of severe asthma using reconstituted human bronchial epithelium. J Allergy Clin Immunol 129:1259-66.e1.
23. Hackett TL, Singhera GK, Shaheen F, et al. (2011). Intrinsic phenotypic differences of asthmatic epithelium and its inflammatory responses to respiratory syncytial virus and air pollution. Am J Respir Cell Mol Biol 45:1090-100.
24. Halwani R, Al-Muhsen S, Al-Jahdali H, Hamid Q. (2011). Role of transforming growth factor-beta in airway remodeling in asthma. Am J Respir Cell Mol Biol 44:127-33.
25. Harris PA, Taylor R, Thielke R, et al. (2009). Research electronic data capture (REDCap) - a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform 42:377-81.
26. Haswell LE, Hewitt K, Thorne D, et al. (2010). Cigarette smoke total particulate matter increases mucous secreting cell numbers in vitro: a potential model of goblet cell hyperplasia. Toxicol in Vitro 24:981-7.
27. Holder AL, Lucas D, Goth-Goldstein R, Koshland CP. (2008). Cellular response to diesel exhaust particles strongly depends on the exposure method. Toxicol Sci 103:108-15. (Pubitemid 351524482)
28. Holgate ST. (2011). The sentinel role of the airway epithelium in asthma pathogenesis. Immunol Rev 242:205-19.
29. Huggins FE, Huffman GP, Robertson JD. (2000). Speciation of elements in NIST particulate matter SRMs 1648 and 1650. J Hazard Mater 74: 1-23. (Pubitemid 30227266)
30. Jiang N, Dreher KL, Dye JA, et al. (2000). Residual oil fly ash induces cytotoxicity and mucin secretion by guinea pig tracheal epithelial cells via an oxidant-mediated mechanism. Toxicol Appl Pharmacol 163: 221-30. (Pubitemid 30158551)
31. Karp PH, Moninger TO, Weber SP, et al. (2002). An in vitro model of differentiated human airway epithelia. Methods for establishing primary cultures. Methods Mol Biol 188:115-37.
32. Kicic A, Sutanto EN, Stevens PT, et al. (2006). Intrinsic biochemical and functional differences in bronchial epithelial cells of children with asthma. Am J Respir Crit Care Med 174:1110-18. (Pubitemid 44772081)
33. Kim JJ; American Academy of Pediatrics Committee on Environmental Health. (2004). Ambient air pollution: health hazards to children. Pediatrics 114:1699-707.
34. Lee CG, Link H, Baluk P, et al. (2004). Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2- mediated sensitization and inflammation in the lung. Nat Med 10: 1095-103. (Pubitemid 39424871)
35. Lee JY, Park SW, Chang HK, et al. (2006). A disintegrin and metalloproteinase 33 protein in patients with asthma: relevance to airflow limitation. Am J Respir Crit Care Med 173:729-35.
36. Looi K, Sutanto EN, Banerjee B, et al. (2011). Bronchial brushings for investigating airway inflammation and remodelling. Respirology 16: 725-37.
37. Lopez-Guisa JM, Powers C, File D, et al. (2012). Airway epithelial cells from asthmatic children differentially express proremodeling factors. J Allergy Clin Immunol 129:990-7.e6.
38. Miller MR, Hankinson J, Brusasco V, et al. (2005). Standardisation of spirometry. Eur Respir J 26:319-38. (Pubitemid 41079078)
39. Parker J, Sarlang S, Thavagnanam S, et al. (2010). A 3-D welldifferentiated model of pediatric bronchial epithelium demonstrates unstimulated morphological differences between asthmatic and nonasthmatic cells. Pediatr Res 67:17-22.
40. Pellegrino R, Viegi G, Brusasco V, et al. (2005). Interpretative strategies for lung function tests. Eur Respir J 26:948-68. (Pubitemid 41632054)
41. Pezzulo AA, Starner TD, Scheetz TE, et al. (2011). The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epithelia. Am J Physiol Lung Cell Mol Physiol 300:L25-31.
42. Pfaffl MW. (2001). A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29:e45.
43. Pierse N, Rushton L, Harris RS, et al. (2006). Locally generated particulate pollution and respiratory symptoms in young children. Thorax 61:216-20.
44. Po JY, FitzGerald JM, Carlsten C. (2011). Respiratory disease associated with solid biomass fuel exposure in rural women and children: systematic review and meta-analysis. Thorax 66:232-9.
45. Quay JL, Reed W, Samet J, Devlin RB. (1998). Air pollution particles induce IL-6 gene expression in human airway epithelial cells via NF-kappaB activation. Am J Respir Cell Mol Biol 19:98-106. (Pubitemid 128354946)
46. Rogers DF. (2007). Physiology of airway mucus secretion and pathophysiology of hypersecretion. Respir Care 52:1134-46. (discussion 1146-9).
47. Ruckerl R, Schneider A, Breitner S, et al. (2011). Health effects of particulate air pollution: a review of epidemiological evidence. Inhal Toxicol 23:555-92.
48. Sacks JD, Stanek LW, Luben TJ, et al. (2011). Particulate matter-induced health effects: who is susceptible? Environ Health Perspect 119: 446-54.
49. Salvi S. (2007). Health effects of ambient air pollution in children. Paediatr Respir Rev 8:275-80. (Pubitemid 350082039)
50. Schroeder A, Mueller O, Stocker S, et al. (2006). The RIN: an RNA integrity number for assigning integrity values to RNA measurements. BMC Mol Biol 7:3.
51. Schultz ES, Gruzieva O, Bellander T, et al. (2012). Traffic-related air pollution and lung function in children at 8 years of age: a birth cohort study. Am J Respir Crit Care Med 186:1286-91.
52. Selevan SG, Kimmel CA, Mendola P. (2000). Identifying critical windows of exposure for children's health. Environ Health Perspect 108:451-5.
53. Shoenfelt J, Mitkus RJ, Zeisler R, et al. (2009). Involvement of TLR2 and TLR4 in inflammatory immune responses induced by fine and coarse ambient air particulate matter. J Leukoc Biol 86:303-12.
54. Silbajoris R, Osornio-Vargas AR, Simmons SO, et al. (2011). Ambient particulate matter induces interleukin-8 expression through an alternative NF-kappaB (nuclear factor-kappa B) mechanism in human airway epithelial cells. Environ Health Perspect 119:1379-83.
55. Strandberg K, Palmberg L, Larsson K. (2007). Effect of formoterol and salmeterol on IL-6 and IL-8 release in airway epithelial cells. Respir Med 101:1132-9.
56. Swindle EJ, Collins JE, Davies DE. (2009). Breakdown in epithelial barrier function in patients with asthma: identification of novel therapeutic approaches. J Allergy Clin Immunol 124:23-34 (quiz 35-6).
57. United States Environmental Protection Agency. (2012). Our nation's air - status and trends through 2010. Available from: http://www.epa.gov/airtrends/ 2011/report/fullreport.pdf [last accessed: 15 Sep 2012].
58. Vedal S, Petkau J, White R, Blair J. (1998). Acute effects of ambient inhalable particles in asthmatic and nonasthmatic children. Am J Respir Crit Care Med 157:1034-43.
59. Vincent R, Goegan P, Johnson G, et al. (1997). Regulation of promoter- CAT stress genes in HepG2 cells by suspensions of particles from ambient air. Fundam Appl Toxicol 39:18-32.
60. Volckens J, Dailey L, Walters G, Devlin RB. (2009). Direct particle-tocell deposition of coarse ambient particulate matter increases the production of inflammatory mediators from cultured human airway epithelial cells. Environ Sci Technol 43:4595-9.
61. Voynow JA, Rubin BK. (2009). Mucins, mucus, and sputum. Chest 135: 505-12.
62. Yu H, Li Q, Kolosov VP, et al. (2012). Regulation of cigarette smokemediated mucin expression by hypoxia-inducible factor-1alpha via epidermal growth factor receptor-mediated signaling pathways. J Appl Toxicol 32:282-92.
63. Zajac L, Sprecher E, Landrigan PJ, Trasande L. (2009). A systematic review of US state environmental legislation and regulation with regards to the prevention of neurodevelopmental disabilities and asthma. Environ Health 8:9.