CARD-024, a vitamin D analog, attenuates the pro-fibrotic response to substrate stiffness in colonic myofibroblasts

Experimental and Molecular Pathology

Volumn 93, Issue 1, 2012, Pages 91-98

  Johnson, Laura A ^a   Sauder, Kay L ^a   Rodansky, Eva S ^a   Simpson, Robert U ^a   Higgins, Peter D R ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

CARD 024; Crohn's disease; Fibrosis; Matrix stiffness; Myofibroblast; Vitamin D

Indexed keywords

1 ALPHA HYDROXYVITAMIN D5; ALPHA SMOOTH MUSCLE ACTIN; CARD 024; CYCLOOXYGENASE 2; FOCAL ADHESION KINASE; INTERLEUKIN 1BETA; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VITAMIN D DERIVATIVE;

ACTIN FILAMENT; ARTICLE; CELL MATURATION; CELL STIMULATION; CELL STRUCTURE; CELL TRANSFORMATION; COLONIC MYOFIBROBLAST; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG RESPONSE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME REPRESSION; ET1 GENE; EXTRACELLULAR MATRIX; FIBROGENIC GENE; FOCAL ADHESION; GENE; GENE EXPRESSION; GENE INDUCTION; HUMAN; HUMAN CELL; HYPERCALCEMIA; INFLAMMATION; INTESTINAL FIBROSIS; MLCK GENE; MYOFIBROBLAST; PHENOTYPE; PROTEIN EXPRESSION; STELLATE CELL; STRESS FIBER;

ACTINS; CELL CULTURE TECHNIQUES; CELL LINE; COLON; CYCLOOXYGENASE 2; ENDOTHELIN-1; FIBROSIS; FOCAL ADHESION KINASE 1; FOCAL ADHESIONS; HUMANS; HYDROXYCHOLECALCIFEROLS; INTERLEUKIN-1BETA; MYOFIBROBLASTS; PEPTIDES; STRESS FIBERS; TRANSFORMING GROWTH FACTOR BETA; VITAMIN D;

EID: 84860809498     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2012.04.014     Document Type: Article

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