Lys-63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized α-Synuclein

Journal of Biological Chemistry

Volumn 289, Issue 26, 2014, Pages 18137-18151

  Sugeno, Naoto ^a   Hasegawa, Takafumi ^a   Tanaka, Nobuyuki ^b   Fukuda, Mitsunori ^a   Wakabayashi, Koichi ^c   Oshima, Ryuji ^a,b   Konno, Masashi ^a   Miura, Emiko ^a   Kikuchi, Akio ^a   Baba, Toru ^a   Anan, Tadashi ^d   Nakao, Mitsuyoshi ^d   Geisler, Sven ^e   Aoki, Masashi ^a   Takeda, Atsushi ^a,f  

^a TOHOKU UNIVERSITY   (Japan)

^b MIYAGI CANCER CENTER RESEARCH INSTITUTE   (Japan)

^c HIROSAKI UNIVERSITY   (Japan)

^d KUMAMOTO UNIVERSITY   (Japan)

^e UNIVERSITY OF TÜBINGEN   (Germany)

^f National Hospital Organization Sendai Nishitaga Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES;

CUMULATIVE EVIDENCE; DOWN-REGULATED PROTEINS; NEURAL PRECURSORS; NEURODEGENERATION; PARKINSON DISEASE; POLYUBIQUITINATION; PROLINE-RICH SEQUENCES; UBIQUITIN LIGASES;

CYTOLOGY;

ALPHA SYNUCLEIN; LYSINE; UBIQUITIN PROTEIN LIGASE NEDD4; UBIQUITIN PROTEIN LIGASE NEDD4 1; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENDOSOME; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERNALIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; UBIQUITINATION; WILD TYPE;

E3 UBIQUITIN LIGASE; MEMBRANE TRAFFICKING; NEUROBIOLOGY; PARKINSON DISEASE; PROPAGATION; UBIQUITINATION; Α-SYNUCLEIN (AS);

ALPHA-SYNUCLEIN; AMINO ACID MOTIFS; CELL LINE, TUMOR; ENDOSOMAL SORTING COMPLEXES REQUIRED FOR TRANSPORT; ENDOSOMES; HUMANS; LYSINE; PARKINSON DISEASE; PROTEIN TRANSPORT; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84903538644     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.529461     Document Type: Article

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