Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease

Neurobiology of Disease

Volumn 64, Issue , 2014, Pages 79-87

  Davies, Sian E ^a,b   Hallett, Penelope J ^c   Moens, Thomas ^a   Smith, Gaynor ^c   Mangano, Emily ^c   Kim, Hyoung Tae ^d   Goldberg, Alfred L ^d   Liu, Ji Long ^b   Isacson, Ole ^c   Tofaris, George K ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c MCLEAN HOSPITAL   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Endosomal trafficking; Lysosome; Protein degradation; Ubiquitination

Indexed keywords

ALPHA SYNUCLEIN; UBIQUITIN PROTEIN LIGASE NEDD4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CELL LOSS; DOPAMINERGIC NERVE CELL; DROSOPHILA; MALE; MOTOR DYSFUNCTION; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; RNA INTERFERENCE; SUBSTANTIA NIGRA; WILD TYPE;

ENDOSOMAL-TRAFFICKING; LYSOSOME; PROTEIN-DEGRADATION; UBIQUITINATION;

ALPHA-SYNUCLEIN; ANIMALS; ANIMALS, GENETICALLY MODIFIED; BRAIN; DOPAMINERGIC NEURONS; DROSOPHILA; ENDOSOMAL SORTING COMPLEXES REQUIRED FOR TRANSPORT; EYE; FEMALE; HUMANS; LOCOMOTION; MALE; MUTATION; NERVE DEGENERATION; PARKINSONIAN DISORDERS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SUBSTANTIA NIGRA; UBIQUITIN-PROTEIN LIGASES;

EID: 84892456555     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2013.12.011     Document Type: Article

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