Valproic acid-induced deregulation In vitro of genes associated in vivo with neural tube defects

Toxicological Sciences

Volumn 108, Issue 1, 2009, Pages 132-148

  Jergil, Måns ^a   Kultima, Kim ^a,c   Gustafson, Anne Lee ^b   Dencker, Lennart ^a   Stigson, Michael ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

^c UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Alternative methods; Embryonal carcinoma cells; Exencephaly; Histone deacetylase inhibitor; In vitro toxicology; Microarray; Neural tube defects; Teratogen; Toxicogenomics; Valproic acid

Indexed keywords

HISTONE DEACETYLASE; RNA; TERATOGENIC AGENT; VALPROIC ACID;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; EMBRYO; ENZYME INHIBITION; EXENCEPHALY; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENE TARGETING; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; IN VITRO STUDY; IN VIVO STUDY; KNOCKOUT MOUSE; MALFORMATION SYNDROME; MICROARRAY ANALYSIS; MOLECULAR PROBE; MOUSE; NEURAL TUBE DEFECT; NONHUMAN; PHENOTYPE; PLURIPOTENT STEM CELL; PROBABILITY; RNA EXTRACTION; TERATOGENICITY; TOXICOGENETICS; TRANSCRIPTION REGULATION; UPREGULATION;

MUS;

EID: 61349131471     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfp002     Document Type: Article

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