A statistical approach towards the derivation of predictive gene sets for potency ranking of chemicals in the mouse embryonic stem cell test

Toxicology Letters

Volumn 225, Issue 3, 2014, Pages 342-349

  Schulpen, Sjors H W ^a,b   Pennings, Jeroen L A ^a   Tonk, Elisa C M ^a,c   Piersma, Aldert H ^a,b  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Concentration response analysis; Developmental toxicity; Embryonic stem cell test; Gene set; Phthalate monoesters; Potency ranking

Indexed keywords

BIOLOGICAL MARKER; PHTHALIC ACID; PHTHALIC ACID DERIVATIVE; TERATOGENIC AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CONCENTRATION RESPONSE; DEVELOPMENTAL TOXICITY; EMBRYONIC STEM CELL; GENE EXPRESSION; IN VITRO STUDY; MOUSE; NONHUMAN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; STEM CELL CULTURE; TRANSCRIPTOMICS; UPREGULATION; ABNORMALITIES, DRUG-INDUCED; ALGORITHM; ANIMAL; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHYSIOLOGY; PREDICTIVE VALUE; PROCEDURES; RANDOMIZATION; TOXICITY; TOXICITY TESTING;

ABNORMALITIES, DRUG-INDUCED; ALGORITHMS; ANIMALS; CELL DIFFERENTIATION; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYONIC STEM CELLS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MICE; PHTHALIC ACIDS; PREDICTIVE VALUE OF TESTS; RANDOM ALLOCATION; TERATOGENS; TOXICITY TESTS;

EID: 84893489191     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2014.01.017     Document Type: Article

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