Accelerated disease onset with stabilized familial amyotrophic lateral sclerosis (ALS)-linked mutant TDP-43 proteins

Journal of Biological Chemistry

Volumn 288, Issue 5, 2013, Pages 3641-3654

  Watanabe, Shoji ^a,b   Kaneko, Kumi ^a   Yamanaka, Koji ^a,c,d,e  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^b DOSHISHA UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d SAITAMA UNIVERSITY   (Japan)

^e KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMYOTROPHIC LATERAL SCLEROSIS; BIOCHEMICAL PHENOTYPES; CELL MODEL; DNA-BINDING PROTEIN; HALF LIVES; MRNA LEVEL; MUTANT PROTEINS; PATHOGENIC PROTEINS; PROTEIN ACCUMULATION; WILD TYPES;

NUCLEIC ACIDS; PROTEINS;

NEURODEGENERATIVE DISEASES;

DETERGENT; MESSENGER RNA; PROTEASOME; TAR DNA BINDING PROTEIN;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; BIOCHEMISTRY; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOTOXICITY; DISEASE COURSE; DISEASE DURATION; FAMILY HISTORY; GENE; GENE MUTATION; HALF LIFE TIME; HUMAN; HUMAN CELL; ONSET AGE; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN HOMEOSTASIS; TDP43 GENE; WILD TYPE;

ADULT; AGE OF ONSET; AGED; AMINO ACID SEQUENCE; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CELL DEATH; CELL NUCLEUS; DETERGENTS; DNA-BINDING PROTEINS; EXONS; GENE EXPRESSION REGULATION; HUMANS; MICE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; MUTATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN STABILITY; PROTEIN TRANSPORT; RNA, MESSENGER; SOLUBILITY; SUBCELLULAR FRACTIONS; TIME FACTORS;

EID: 84873314938     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.433615     Document Type: Article

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