Synthesis and NK-2 antagonist effect of 1,6-diphenyl-pyrazolo [3,4-d]-thiazolo[3,2-a]4H-pyrimidin-4-one

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 1, 1996, Pages 59-64

  Guccione, Salvatora ^a   Modica, Marie ^a   Longmore, Jeanette ^b   Shaw, David ^b   Uccello Barretta, Gloria ^c   Santagati, Andrea ^a   Santagati, Maria ^a   Rasso, Filippo ^a  

^a UNIVERSITY OF CATANIA   (Italy)

^b NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

1,6 DIPHENYLPYRAZOLO[3,4 D]THIAZOLO[3,2 A]PYRIMIDIN 4 ONE; CALCIUM CHANNEL; NEUROKININ 1 RECEPTOR; NEUROKININ 2 RECEPTOR; NEUROKININ 3 RECEPTOR; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; GUINEA PIG; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; SMOOTH MUSCLE CONTRACTION; STRUCTURE ACTIVITY RELATION; TRACHEA;

ANIMALIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0030028133     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(95)00558-B     Document Type: Article

References (32)

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32. 3 9) 8 8.33(s, pyrazole H3), 7.24(s, H7 thiazole),8.08(N-phenyl, 2H protons),7.59(N-phenyl, 2H protons), 7.40 (N-phenyl 1H proton), 7.3-7.5(phenyl 2H protons), 7.3-7.5(phenyl 2H protons),7.3-7.5(phenyl 1H proton); 9 8.23(s, 1H, thiazole), 8.35(s, 1H, pyrazole), 7.57(d, Jvic= 9 Hz, Ar 8), 7.46(t, 2H,Jvic= 9 Hz, Ar 8), 7.50-7.60m, (5H, Ar 1). Column chromatograpny of compounds 6,12,13 was performed on Silica gel 60, Merck (230-400 Mesh ASTM), system: ethyl acetate 6, cyclohexane-ethyl acetate(ψ=40%) 12,13.