Novel 3-substituted-1-aryl-5-phenyl-6-anilinopyrazolo[3,4-d]pyrimidin-4- ones: Docking, synthesis and pharmacological evaluation as a potential anti-inflammatory agents

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 21, 2012, Pages 6616-6620

  Yewale, Sandeep B ^a   Ganorkar, Saurabh B ^b   Baheti, Kamalkishor G ^a   Shelke, Rupesh U ^c  

^a Y B CHAVAN COLLEGE OF PHARMACY   (India)

^b R C PATEL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH   (India)

^c GOVERNMENT COLLEGE OF PHARMACY   (India)

Author keywords

Anti inflammatory activity; COX 2 Selectivity; Docking; Pyrazolo 3,4 d pyrimidin 4 ones; Ulcerogenic potential

Indexed keywords

1 ARYL 3 THIOMETHYL 5 PHENYL PYRAZOLO [3,4 D] PYRIMIDINE; 3 METHYLTHIO 1 ARYL 5 PHENYL 6 ANILINO 2H PYRAZOLO [3,4 D]PYRIMIDIN 4 ONE; ANTIINFLAMMATORY AGENT; AROMATIC AMINE; CELECOXIB; DICLOFENAC; ETHYL (5 AMINO 3 METHYLTHIO 1 ARYL 5 PHENYL 2H PYRAZOLE) 4 CARBOXYLATE; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CATALYST; CHEMICAL REACTION; DRUG SCREENING; DRUG SYNTHESIS; EDEMA; MOLECULAR DOCKING; ULCEROGENESIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; DICLOFENAC; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; MOLECULAR STRUCTURE; PROTEIN BINDING; PYRAZOLES; PYRIMIDINONES; RATS; SULFONAMIDES;

EID: 84867582663     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.08.119     Document Type: Article

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