A new pyrazolo pyrimidine derivative inhibitor of cyclooxygenase-2 with anti-angiogenic activity

European Journal of Pharmacology

Volumn 488, Issue 1-3, 2004, Pages 225-230

  Devesa, Isabel ^a   Alcaraz, M José ^a   Riguera, Ricardo ^b   Ferrándiz, M Luisa ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Angiogenesis; Carrageenan induced paw oedema; Cyclooxygenase 2 inhibitor; Prostaglandin E2; Zymosan injected mouse air pouch

Indexed keywords

ANALGESIC AGENT; ANGIOGENESIS INHIBITOR; CARRAGEENAN; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; N4 BENZYL N6,N6 DIMETHYL 1,1 TERT BUTYL 1H PYRAZOLO[3,4 D]PYRIMIDINE 6,4 DIAMINE; PROSTAGLANDIN E2; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; ZYMOSAN;

ANALGESIC ACTIVITY; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; GRANULOMA; HYPERALGESIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANGIOGENESIS INHIBITORS; ANIMALS; CARRAGEENAN; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DINOPROSTONE; EDEMA; FEMALE; GRANULOMA; INTERLEUKIN-1; ISOENZYMES; MICE; NEOVASCULARIZATION, PATHOLOGIC; NITROBENZENES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRAZOLES; PYRIMIDINES; RATS; RATS, WISTAR; SULFONAMIDES; TUMOR NECROSIS FACTOR-ALPHA; ZYMOSAN;

EID: 1642316109     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2004.02.015     Document Type: Article

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