Solid lipid excipients - Matrix agents for sustained drug delivery

Journal of Controlled Release

Volumn 188, Issue , 2014, Pages 18-30

  Rosiaux, Yvonne ^a   Jannin, Vincent ^a   Hughes, Sophie ^a   Marchaud, Delphine ^a  

^a GATTEFOSSÉ SAS   (France)

Author keywords

Drug release prediction; Ethanol effect; In vitro in vivo correlation; Lipid excipient; Process technology; Stability

Indexed keywords

CONVERGENCE OF NUMERICAL METHODS; DRUG PRODUCTS;

DRUG RELEASE; DRUG RELEASE MECHANISM; ETHANOL EFFECTS; IN-VIVO; MANUFACTURING PROCESS; PHYSIOLOGICAL CONDITION; PROCESS TECHNOLOGIES; PROCESSING TECHNIQUE;

DRUG DELIVERY;

ACYLGLYCEROL; ALCOHOL; DRUG CARRIER; EXCIPIENT; FATTY ACID; FATTY ALCOHOL; GLYCEROL STEARATE; PRAZIQUANTEL; SOLID LIPID NANOPARTICLE; TRIACYLGLYCEROL; VEGETABLE OIL; WAX; DELAYED RELEASE FORMULATION; DRUG; LIPID;

CHEMICAL PARAMETERS; CORRELATIONAL STUDY; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM; DRUG FORMULATION; DRUG GRANULATION; DRUG MANUFACTURE; DRUG MECHANISM; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; IN VITRO STUDY; IN VIVO STUDY; PH; PREDICTION; PRIORITY JOURNAL; REVIEW; STORAGE TEMPERATURE; SUSTAINED DRUG RELEASE; SUSTAINED RELEASE FORMULATION; ANIMAL; CHEMISTRY; DELAYED RELEASE FORMULATION; HUMAN; MEDICINAL CHEMISTRY; PROCEDURES;

ANIMALS; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; DRUG STABILITY; EXCIPIENTS; HUMANS; LIPIDS; PHARMACEUTICAL PREPARATIONS;

EID: 84903305373     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.06.004     Document Type: Review

References (135)

1. J.B. Cannon Strategies to formulate lipid-based drug delivery systems Am. Pharm. Rev. 14 2011 84 92
2. S.J. DeNigris, M. Hamosh, D.K. Kasbekar, C.S. Fink, T.C. Lee, and P. Hamosh Secretion of human gastric lipase from dispersed gastric glands Biochim. Biophys. Acta 836 1985 67 72 (Pubitemid 15230696)
3. C.J. Porter, C.W. Pouton, J.F. Cuine, and W.N. Charman Enhancing intestinal drug solubilisation using lipid-based delivery systems Adv. Drug Deliv. Rev. 60 2008 673 691
4. C.W. Pouton, and C.J. Porter Formulation of lipid-based delivery systems for oral administration: materials, methods and strategies Adv. Drug Deliv. Rev. 60 2008 625 637
5. T.A. Miller Pharmaceutical tablet lubrication Int. J. Pharm. 41 1988 1 19 (Pubitemid 18017601)
6. E. Fahy, S. Subramaniam, H.A. Brown, C.K. Glass, A.H. Merrill Jr., R.C. Murphy, C.R. Raetz, D.W. Russell, Y. Seyama, W. Shaw, T. Shimizu, F. Spener, M.G. van, M.S. VanNieuwenhze, S.H. White, J.L. Witztum, and E.A. Dennis A comprehensive classification system for lipids J. Lipid Res. 46 2005 839 861
7. K. Priyanka, and A.A. Sathali Preparation and evaluation of montelukast sodium loaded solid lipid nanoparticles J. Young. Pharm. 4 2012 129 137
8. Oral Lipid-based Formulations: Enhancing the Bioavailability of Poorly Water-soluble Drugs 2007 Informa Healthcare New York
9. A. Smith Oxford Dictionary of Biochemistry and Molecular Biology 2000 Oxford University Press Oxford, UK
10. A.L. Weiner Lipids as excipients in pharmaceutical dosage forms 2001 Encyclopedia of Pharmaceutical Technology New York 1659 1673
11. G.N. Fetih Formulation and characterization of Gelucire pellets for sustained release of Ibuprofen Bull. Pharm. Sci. 33 2010 217 224
12. M.R. Rao, A.A. Ranpise, K.C. Thanki, S.G. Borate, and G.N. Parikh Effect of processing and sintering on controlled release wax matrix tablets of ketorolac tromethamine Indian J. Pharm. Sci. 71 2009 538 544
13. H.G. Schroeder, A. Dakkuri, and P.P. DeLuca Sustained release from inert wax matrixes I: drug-wax combinations J. Pharm. Sci. 67 1978 350 353 (Pubitemid 8297783)
14. I. Singh, P. Kumar, N. Rani, and V. Rana Investigation of different lipid based materials as matrices designed to control the release of a hydrophobic drug Int. J. Pharm. Sci. Drug Res. 1 2009 158 163
15. G.M. El-Sayed, Y. El-Said, M.M. Meshali, and J.B. Schwartz Kinetics of theophylline release from different tablet matrices S. T. P Pharma Pratiques 6 1996 390 397
16. M.A. Quadir, M.S. Rahman, M.Z. Karim, S. Akter, M.T. Awkat, and M.S. Reza Evaluation of hydrophobic materials as matrices for controlled-release drug delivery Pak. J. Pharm. Sci. 16 2003 17 28
17. M.H. Amaral, J.M. Lobo, and D.C. Ferreira Effect of hydroxypropyl methylcellulose and hydrogenated castor oil on naproxen release from sustained-release tablets AAPS Pharm. Sci. Techol. 2 2001 E6
18. Y.E. Zhang, and J.B. Schwartz Effect of diluents on tablet integrity and controlled drug release Drug Dev. Ind. Pharm. 26 2000 761 765 (Pubitemid 30397331)
19. B.K. Nanjwade, S.R. Mhase, and F.V. Manvi Formulation of extended-release metformin hydrochloride matrix tablets Trop. J. Pharm. Res. 10 2011 375 383
20. M.M. Meshali, G.M. El-Sayed, H.M. Abd El-Aleem, and Y. El-Said Optimization of theophylline release from tablets containing Compritol STP Pharma Sci. 5 1995 429 434 (Pubitemid 26033788)
21. A.A. Aboelwafa, and E.B. Basalious Optimization and in vivo pharmacokinetic study of a novel controlled release venlafaxine hydrochloride three-layer tablet AAPS Pharm. Sci. Technol. 11 2010 1026 1037
22. J. Ayyappan, P. Umapathi, and D. Quine Development and evaluation of a directly compressible co-processed multifunction sustained release agent for gliclazide sustained release tablets Pharm. Sci. Res. 2 2010 394 400
23. M. Roberts, D. Vellucci, S. Mostafa, C. Miolane, and D. Marchaud Development and evaluation of sustained-release Compritol 888 ATO matrix mini-tablets Drug Dev. Ind. Pharm. 38 2012 1068 1076
24. F.A. Mohamed, M. Roberts, L. Seton, J.L. Ford, M. Levina, and A.R. Rajabi-Siahboomi The influence of HPMC concentration on release of theophylline or hydrocortisone from extended release mini-tablets Drug Dev. Ind. Pharm. 39 2013 1167 1174
25. L.C. Li, and G.E. Peck The effect of agglomeration methods on the micromeritic properties of a maltodextrin product, Maltrin 150 T Drug Dev. Ind. Pharm. 16 1990 491 503
26. M. Hariharan, C. Wowchuk, P. Nkansah, and V.K. Gupta Effect of formulation composition on the properties of controlled release tablets prepared by roller compaction Drug Dev. Ind. Pharm. 30 2004 565 572 (Pubitemid 38924626)
27. G.M. Venkatesh and N.R. Palepu. Controlled release solid dosage forms of lithium carbonate. [US6365196 B1]. 2002.
28. L. Pulcini, M. Roberts, S. Mostafa, and Y. Cuppok Sustained release of diclofenac sodium from wet granulated Compritol 888 ATO matrix tablets Controlled Release Society annual meeting, Personal communication 2012
29. Y.E. Zhang, R. Tchao, and J.B. Schwartz Effect of processing methods and heat treatment on the formation of wax matrix tablets for sustained drug release Pharm. Dev. Technol. 6 2001 131 144 (Pubitemid 32532018)
30. X. Gu, D.J. Fediuk, F.E. Simons, and K.J. Simons Evaluation and comparison of five matrix excipients for the controlled release of acrivastine and pseudoephedrine Drug Dev. Ind. Pharm. 30 2004 1009 1017 (Pubitemid 39577993)
31. N.S. Barakat, I.M. Elbagory, and A.S. Almurshedi Controlled-release carbamazepine granules and tablets comprising lipophilic and hydrophilic matrix components AAPS Pharm. Sci. Technol. 9 2008 1054 1062
32. J. Hamdani, A.J. Moes, and K. Amighi Development and evaluation of prolonged release pellets obtained by the melt pelletization process Int. J. Pharm. 245 2002 167 177 (Pubitemid 35299902)
33. S.N. Patere, N.S. Desai, A.S. Jain, P.P. Kadam, U.M. Thatte, N. Gogtay, C.J. Kapadia, N. Farah, and M.S. Nagarsenker Compritol(R)888 ATO a lipid excipient for sustained release of highly water soluble active: formulation, scale-up and IVIVC study Curr. Drug Deliv. 10 2013 548 556
34. T. Schaefer Melt agglomeration with Polyethylene glycols in High Shear Mixers 1996 The Royal Danish School of Pharmacy Copenhagen
35. R. Thies, and P. Kleinebudde Melt pelletisation of a hygroscopic drug in a high shear mixer. Part 2. Mutual compensation of influence variables Eur. J. Pharm. Sci. 10 2000 103 110 (Pubitemid 30155931)
36. J.M. Keen, J.R. Hughey, R.C. Bennett, C. Martin, Y. Cuppok, V. Jannin, J. Musakhanian, D. Marchaud, and J.W. McGinity Melt granulation using a twin screw extruder to obtain lipid granules containing tramadol HCl AAPS Annual Meeting and Exposition, Personal communication 2012
37. B.J. Boyd, T.H. Nguyen, and A. Muellertz Lipids in oral controlled release drug delivery C.G. Wilson, P.J. Crowley, Controlled Release in Oral Drug Delivery 2011 Springer US 299 327
38. D.M. Patel, N.M. Patel, V.F. Patel, and D.A. Bhatt Floating granules of ranitidine hydrochloride-gelucire 43/01: formulation optimization using factorial design AAPS Pharm. Sci. Technol. 8 2007 (Article)
39. Y.P. Wang, Y. Gan, and X.X. Zhang Novel gastroretentive sustained-release tablet of tacrolimus based on self-microemulsifying mixture: in vitro evaluation and in vivo bioavailability test Acta Pharmacol. Sin. 32 2011 1294 1302
40. E. Mehuys, C. Vervaet, I. Gielen, B.H. Van, and J.P. Remon In vitro and in vivo evaluation of a matrix-in-cylinder system for sustained drug delivery J. Control. Release 96 2004 261 271 (Pubitemid 38481508)
41. S. Adnan, A.S. Nisar-Ur-Rhaman, S.M. Khanand, and S. Saeed-ul-Hassa In vitro comparison of sustained release hydroxypropylmethyl cellulose and lipid-based matrix systems of diltiazem HCl Pak. J. Zool. 42 2010 515 519
42. V. Jannin, E. Pochard, and O. Chambin Influence of poloxamers on the dissolution performance and stability of controlled-release formulations containing Precirol ATO 5 Int. J. Pharm. 309 2006 6 15 (Pubitemid 43129459)
43. P.V. Parab, C.K. Oh, and W.A. Ritschel Sustained release from precirol (glycerol palmito-stearate) matrix. effect of mannitol and hydroxypropyl methylcellulose on the release of theophylline Drug Dev. Ind. Pharm. 12 1986 1309 1327 (Pubitemid 16064262)
44. M. Savolainen, J. Herder, C. Khoo, K. Lovqvist, C. Dahlqvist, H. Glad, and A.M. Juppo Evaluation of polar lipid-hydrophilic polymer microparticles Int. J. Pharm. 262 2003 47 62 (Pubitemid 36966693)
45. M. Ozyazici, E.H. Gokce, and G. Ertan Release and diffusional modeling of metronidazole lipid matrices Eur. J. Pharm. Biopharm. 63 2006 331 339 (Pubitemid 44218741)
46. J. Liu, F. Zhang, and J.W. McGinity Properties of lipophilic matrix tablets containing phenylpropanolamine hydrochloride prepared by hot-melt extrusion Eur. J. Pharm. Biopharm. 52 2001 181 190 (Pubitemid 32755897)
47. D. Saraiya, and S. Bolton The use of precirol to prepare sustained release tablets of theophylline and quinidine gluconate Drug Dev. Ind. Pharm. 16 1990 1963 1969 (Pubitemid 20300935)
48. W. Bowtle Lipid formulations for oral drug delivery Pharm. Technol. Eur. 12 2000 20
49. E. Pallagi, K. Vass, K. Pintye-Hodi, P. Kasa Jr., G. Falkay, I. Eros, and P. Szabo-Revesz Iron(II) sulfate release from drop-formed lipophilic matrices developed by special hot-melt technology Eur. J. Pharm. Biopharm. 57 2004 287 294 (Pubitemid 38283705)
50. J.A. Krause Novel Pediatric Formulations for the Drug Sodium Benzoate 2008 Heinrich-Heine Universität Düsseldorf
51. K. Vithani, M. Maniruzzaman, I.J. Slipper, S. Mostafa, C. Miolane, Y. Cuppok, D. Marchaud, and D. Douroumis Sustained release solid lipid matrices processed by hot-melt extrusion (HME) Colloids Surf. B: Biointerfaces 110 2013 403 410
52. J.M. Keen, J.R. Hughey, R.C. Bennett, V. Jannin, and J.W. McGinity Preparation of hot-melt extruded supersaturating solid dispersions containing glyceryl behenate: effects on processability, supersaturation and rate of release AAPS Annual Meeting and Exposition, Personal communication 2011
53. J. Krause and J. Breitkreutz. Lipid pellets with enhanced taste-masking. European Patent [EP2172191 A1]. 2010.
54. B. Albertini, N. Passerini, F. Pattarino, and L. Rodriguez New spray congealing atomizer for the microencapsulation of highly concentrated solid and liquid substances Eur. J. Pharm. Biopharm. 69 2008 348 357 (Pubitemid 351467155)
55. M. Savolainen, C. Khoo, H. Glad, C. Dahlqvist, and A.M. Juppo Evaluation of controlled-release polar lipid microparticles Int. J. Pharm. 244 2002 151 161 (Pubitemid 35245455)
56. Y. Akiyama, M. Yoshioka, H. Horibe, S. Hirai, N. Kitamori, and H. Toguchi Novel oral controlled-release microspheres using polyglycerol esters of fatty acids J. Control. Release 26 1993 1 10 (Pubitemid 23204073)
57. L. Rodriguez, N. Passerini, C. Cavallari, M. Cini, P. Sancin, and A. Fini Description and preliminary evaluation of a new ultrasonic atomizer for spray-congealing processes Int. J. Pharm. 183 1999 133 143 (Pubitemid 29257959)
58. V. Jannin, and Y. Cuppok Hot-melt coating with lipid excipients Int. J. Pharm. 457 2013 480 487
59. W.H. De Jong, and P.J. Borm Drug delivery and nanoparticles:applications and hazards Int. J. Nanomedicine 3 2008 133 149
60. R.P. Singh, and P. Ramarao Accumulated polymer degradation products as effector molecules in cytotoxicity of polymeric nanoparticles Toxicol. Sci. 136 2013 131 143
61. M.K. Rawat, A. Jain, and S. Singh Studies on binary lipid matrix based solid lipid nanoparticles of repaglinide: in vitro and in vivo evaluation J. Pharm. Sci. 100 2011 2366 2378
62. W. Mehnert, and K. Mader Solid lipid nanoparticles: production, characterization and applications Adv. Drug Deliv. Rev. 47 2001 165 196 (Pubitemid 32324113)
63. A.C. Silva, D. Santos, D.C. Ferreira, and E.B. Souto Oral delivery of drugs by means of lipid nanoparticles Internation Workshop on Bioencapsulation, Personal communication 2006
64. U.H. Cegla Long-term therapy over 2 years with ambroxol (Mucosolvan) retard capsules in patients with chronic bronchitis. Results of a double-blind study of 180 patients Prax. Klin. Pneumol. 42 1988 715 721
65. P. Speiser. Lipid nanopellets as carrier system for drugs for oral administration. European Patent EP0167825 B1. 1990.
66. L. Dellamary, D.J. Smith, A. Bloom, S. Bot, G.R. Guo, H. Deshmuk, M. Costello, and A. Bot Rational design of solid aerosols for immunoglobulin delivery by modulation of aerodynamic and release characteristics J. Control. Release 95 2004 489 500 (Pubitemid 38340499)
67. H. Reithmeier, J. Herrmann, and A. Gopferich Lipid microparticles as a parenteral controlled release device for peptides J. Control. Release 73 2001 339 350 (Pubitemid 32539261)
68. H. Reithmeier, J. Herrmann, and A. Gopferich Development and characterization of lipid microparticles as a drug carrier for somatostatin Int. J. Pharm. 218 2001 133 143 (Pubitemid 32406164)
69. E.E. Hassan, A.G. Eshra, and A.H. Nada Formulation of prolonged release lipid micropellets by emulsion congealing: optimization of ketoprofen entrapment and release Int. J. Pharm. 121 1995 149 155
70. L. Perge, M. Robitzer, C. Guillemot, J.M. Devoisselle, F. Quignard, and P. Legrand New solid lipid microparticles for controlled ibuprofen release: formulation and characterization study Int. J. Pharm. 422 2012 59 67
71. M. Uner, U. Gonullu, G. Yener, and T. Altinkurt A new approach for preparing a controlled release ketoprofen tablets by using beeswax Farmaco 60 2005 27 31 (Pubitemid 40126285)
72. R. Bodmeier, O. Paeratakul, H. Chen, and W. Zhang Formation of sustained release wax matrices within hard gelatin capsules in a fluidized bed Drug Dev. Ind. Pharm. 16 1990 1505 1519 (Pubitemid 20204849)
73. J.L. Bruguera, M. Lamoise, C. Mikler, and E. Teillaud Méthodologie de formulation: micromatrices à libération prolongée de théophylline Bull. Tech. Gattefossé 83 1990 33 48
74. A.B. Dennis, S.J. Farr, I.W. Kellaway, G. Taylor, and R. Davidson In vivo evaluation of rapid release and sustained release Gelucire capsule formulations Int. J. Pharm. 65 1990 85 100
75. T. Sakamoto, T. Takeda, and Y. Suzuki. Sustained-release proeparations and the process thereof. US patent [US 5023089 A1]. 1991.
76. I. Grizzi, H. Garreau, S. Li, and M. Vert Hydrolytic degradation of devices based on poly(DL-lactic acid) size-dependence Biomaterials 16 1995 305 311
77. L. Lu, C.A. Garcia, and A.G. Mikos In vitro degradation of thin poly(DL-lactic-co-glycolic acid) films J. Biomed. Mater. Res. 46 1999 236 244
78. F. Kreye, F. Siepmann, A. Zimmer, J.F. Willart, M. Descamps, and J. Siepmann Controlled release implants based on cast lipid blends Eur. J. Pharm. Sci. 43 2011 78 83
79. J. Siepmann, and F. Siepmann Mathematical modeling of drug release from lipid dosage forms Int. J. Pharm. 418 2011 42 53
80. Y. Fu, and W.J. Kao Drug release kinetics and transport mechanisms of non-degradable and degradable polymeric delivery systems Expert Opin. Drug Deliv. 7 2010 429 444
81. W.B. Liechty, D.R. Kryscio, B.V. Slaughter, and N.A. Peppas Polymers for drug delivery systems Annu. Rev. Chem. Biomol. Eng. 1 2010 149 173
82. M. Üner, and B. Çelebi Design of hydralazine hydrochloride matrix tablets based on various polymers and lipids Ind. J. Pharm. Edu. Res. 46 2012 75 87
83. V. Patel, and N.M. Patel Controlled release dipyridamole from floating matrices prepared using glyceryl behenate Drug Deliv. Technol. 8 2008 54 59
84. F. Kreye, F. Siepmann, and J. Siepmann Drug release mechanisms of compressed lipid implants Int. J. Pharm. 404 2011 27 35
85. S. Güres, F. Siepmann, J. Siepmann, and P. Kleinebudde Drug release from extruded solid lipid matrices: theoretical predictions and independent experiments Eur. J. Pharm. Biopharm. 80 2012 122 129
86. F. Kreye, F. Siepmann, J.F. Willart, M. Descamps, and J. Siepmann Drug release mechanisms of cast lipid implants Eur. J. Pharm. Biopharm. 78 2011 394 400
87. S. Schulze, and G. Winter Lipid extrudates as novel sustained release systems for pharmaceutical proteins J. Control. Release 134 2009 177 185
88. G. Treanor, M. Roberts, S. Mostafa, and C. Miolane Diluent effects on drug release from sustained-release Compritol 888 ATO tablets J. Pharm. Pharmacol. 62 2010 1419 1420
89. S. El-Shanawany Sustained-release of nitrofurantoin from inert wax matrices J. Control. Release 26 1993 11 19 (Pubitemid 23204074)
90. S. Herrmann, G. Winter, S. Mohl, F. Siepmann, and J. Siepmann Mechanisms controlling protein release from lipidic implants: effects of PEG addition J. Control. Release 118 2007 161 168 (Pubitemid 46343669)
91. S. Mohl, and G. Winter Continuous release of rh-interferon alpha-2a from triglyceride matrices J. Control. Release 97 2004 67 78 (Pubitemid 38624510)
92. G.L. Sax Twin-screw extruded lipid implants for controlled protein drug delivery, Staubing 2012
93. S. Gures, and P. Kleinebudde Dissolution from solid lipid extrudates containing release modifiers Int. J. Pharm. 412 2011 77 84
94. V. Jannin, V. Bérard, and C. Andrès Modification of the drug release of ibuprofen by hot-melt coating with mixes of Compritol 888 ATO and non-ionic surfactants AAPS Annual Meeting and Exposition, Personal communication 2005
95. F.W. Goodhart, R.H. McCoy, and F.C. Ninger Release of a water-soluble drug from a wax matrix timed-release tablet J. Pharm. Sci. 63 1974 1748 1751
96. C. Guse, S. Koennings, F. Kreye, F. Siepmann, A. Goepferich, and J. Siepmann Drug release from lipid-based implants: elucidation of the underlying mass transport mechanisms Int. J. Pharm. 314 2006 137 144
97. P. Pivette, V. Faivre, L. Mancini, C. Gueutin, G. Daste, M. Ollivon, and S. Lesieur Controlled release of a highly hydrophilic API from lipid microspheres obtained by prilling: analysis of drug and water diffusion processes with X-ray-based methods J. Control. Release 158 2012 393 402
98. V. Ratsimbazafy, E. Bourret, and C. Brossard Influence of the manufacturing process on the release of poxyphylline from lipid matrices Pharmazie 52 1997 863 866 (Pubitemid 27489313)
99. J.B. Schwartz, A.P. Simonelli, and W.I. Higuchi Drug release from wax matrices. I. Analysis of data with first-order kinetics and with the diffusion-controlled model J. Pharm. Sci. 57 1968 274 277
100. J.B. Schwartz, A.P. Simonelli, and W.I. Higuchi Drug release from wax matrices II: Application of a mixture theory to the sulfonamide-wax system J. Pharm. Sci. 57 1968 278 282
101. J. Siepmann, and N.A. Peppas Higuchi equation: derivation, applications, use and misuse Int. J. Pharm. 418 2011 6 12
102. N. Fotaki, and M. Vertzoni Biorelevant dissolution methods and their applications in in vitro-in vivo correlations for oral formulations Open Drug Deliv. J. 4 2010 2 13
103. E. Nicolaides, M. Symillides, J.B. Dressman, and C. Reppas Biorelevant dissolution testing to predict the plasma profile of lipophilic drugs after oral administration Pharm. Res. 18 2001 380 388 (Pubitemid 32595828)
104. R. Witzleb, A. Mullertz, V.R. Kanikanti, H.J. Hamann, and P. Kleinebudde Dissolution of solid lipid extrudates in biorelevant media Int. J. Pharm. 422 2012 116 124
105. M. Marques Dissolution media simulating fasted and fed states Dissolut. Technol. 11 2004 16 19
106. E. Jantratid, N. Janssen, C. Reppas, and J.B. Dressman Dissolution media simulating conditions in the proximal human gastrointestinal tract: an update Pharm. Res. 25 2008 1663 1676
107. J.C. Bakala N'Goma, S. Amara, K. Dridi, V. Jannin, and F. Carriere Understanding the lipid-digestion processes in the GI tract before designing lipid-based drug-delivery systems Ther. Deliv. 3 2012 105 124
108. S. Fernandez, V. Jannin, J.D. Rodier, N. Ritter, B. Mahler, and F. Carriere Comparative study on digestive lipase activities on the self emulsifying excipient Labrasol, medium chain glycerides and PEG esters Biochim. Biophys. Acta 1771 2007 633 640 (Pubitemid 46670793)
109. S. Fernandez, V. Jannin, S. Chevrier, Y. Chavant, F. Demarne, and F. Carriere In vitro digestion of the self-emulsifying lipid excipient Labrasol by gastrointestinal lipases and influence of its colloidal structure on lipolysis rate Pharm. Res. 30 2013 3077 3087
110. L. Bonnaire, S. Sandra, T. Helgason, E.A. Decker, J. Weiss, and D.J. McClements Influence of lipid physical state on the in vitro digestibility of emulsified lipids J. Agric. Food Chem. 56 2008 3791 3797 (Pubitemid 351860186)
111. B.K. Nanjwade, D.J. Patel, R.A. Udhani, and F.V. Manvi Functions of lipids for enhancement of oral bioavailability of poorly water-soluble drugs Sci. Pharm. 79 2011 705 727
112. R. Khosla Gastrointestinal Transit of Dosage Forms 1987 University of Nottimgham Nottingham
113. C. Schiller, C.P. Frohlich, T. Giessmann, W. Siegmund, H. Monnikes, N. Hosten, and W. Weitschies Intestinal fluid volumes and transit of dosage forms as assessed by magnetic resonance imaging Aliment. Pharmacol. Ther. 22 2005 971 979 (Pubitemid 41634879)
114. G. Garbacz, R.S. Wedemeyer, S. Nagel, T. Giessmann, H. Monnikes, C.G. Wilson, W. Siegmund, and W. Weitschies Irregular absorption profiles observed from diclofenac extended release tablets can be predicted using a dissolution test apparatus that mimics in vivo physical stresses Eur. J. Pharm. Biopharm. 70 2008 421 428
115. L. Kühnemund, D. Marchaud, E. Dauphin, J.M. Girard, C. Miolane, Y. Cuppok, G. Garbacz, and S. Klein Determining drug release from Compritol 888 ATO matrix formulations World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Personal communication 2012
116. G.M. El-Sayed, Y. El-Said, M.M. Meshali, and J.B. Schwartz Comparative bioavailability of theophylline from tablets with different sustained release kinetics S. T. P Pharma Pratiques 6 1996 398 402
117. E.M. Uronnachi, J.D.N. Ogbonna, F.C. Kenechukwu, A.A. Attama, and V.C. Okore Formulation and in vitro/in vivo evaluation of zidovudine contained in solidified reverse micellar delivery system of immune compromised rats J. Appl. Pharm. Sci. 3 2013 31 35
118. M. Schwab, B. Kessler, E. Wolf, G. Jordan, S. Mohl, and G. Winter Correlation of in vivo and in vitro release data for rh-INFalpha lipid implants Eur. J. Pharm. Biopharm. 70 2008 690 694
119. R.J. Meyer, and A.S. Hussain Awareness Topic: mitigating the risks of ethanoil induced dose dumping from oral sustained/controlled release dosage forms FDA's ACPS meeting, Personal communication 2005
120. M. Rao, A. Ranpise, S. Borate, and K. Thanki Mechanistic evaluation of the effect of sintering on Compritol 888 ATO matrices AAPS Pharm. Sci. Technol. 10 2009 355 360
121. Y. Cuppok, J.M. Girard, C. Miolane, and D. Marchaud Synergic effect of two glycerides to increase stability and ethanol resistance of SR matrix tablets AAPS Annual Meeting and Exposition, Personal communication 2012
122. Y.E. Zhang, and J.B. Schwartz Melt granulation and heat treatment for wax matrix-controlled drug release Drug Dev. Ind. Pharm. 29 2003 131 138 (Pubitemid 36292936)
123. M. Windbergs, S. Gueres, C.J. Strachan, and P. Kleinebudde Two-step solid lipid extrusion as a process to modify dissolution behavior AAPS Pharm. Sci. Technol. 11 2010 2 8
124. J.W. Hagemann Thermal behaviour and polymorphism of acylglycerides N. Garti, K. Sato, Crystallization and Polymorphism of Fats and Fatty Acids Vol. 31 1988 Marcel Dekker New York 9 95
125. L. Hernquist Crystal Structures of Fats and Fatty Acids N. Garti, K. Sato, Crystallization and polymorphism of fats and fatty acids Vol. 31 1988 Marcel Dekker New York 97 137
126. K. Sato Crystallization behaviour of fats and lipids: a review Chem. Eng. Sci. 56 2001 2255 2265 (Pubitemid 33763447)
127. T. Eldem, P. Speiser, and H. Altorfer Polymorphic behavior of sprayed lipid micropellets and its evaluation by differential scanning calorimetry and scanning electron microscopy Pharm. Res. 8 1991 178 184
128. M. Windbergs, C.J. Strachan, and P. Kleinebudde Understanding the solid-state behaviour of triglyceride solid lipid extrudates and its influence on dissolution Eur. J. Pharm. Biopharm. 71 2009 80 87
129. C. Reitz, and P. Kleinebudde Solid lipid extrusion of sustained release dosage forms Eur. J. Pharm. Biopharm. 67 2007 440 448 (Pubitemid 47211916)
130. J.B. Brubach, V. Jannin, B. Mahler, C. Bourgaux, P. Lessieur, P. Roy, and M. Ollivon Structural and thermal characterization of glyceryl behenate by X-ray diffraction coupled to differential calorimetry and infrared spectroscopy Int. J. Pharm. 336 2007 248 256 (Pubitemid 46670648)
131. W. Sutananta, D.Q.M. Craig, and J.M. Newton The effects of ageing on the thermal behaviour and mechanical properties of pharmaceutical glycerides Int. J. Pharm. 111 1994 51 62 (Pubitemid 24277378)
132. S. Herrmann, S. Mohl, and G. Winter Strategies to circumvent polymorphism in sustained release systems based on lipids World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Personal communication 2006
133. H. Yoshino, M. Kobayashi, and M. Samejima Influence of the liquid phase coexisting in fatty suppository bases on the polymorphic transition rate Chem. Pharm. Bull. (Tokyo) 30 1982 2941 2950 (Pubitemid 13235418)
134. J.B. Lo, L.E. Appel, S.M. Herbig, S.B. McCray, and A.G. Thombre Formulation design and pharmaceutical development of a novel controlled release form of azithromycin for single-dose therapy Drug Dev. Ind. Pharm. 35 2009 1522 1529
135. H. Bunjes, M. Drechsler, M.H. Koch, and K. Westesen Incorporation of the model drug ubidecarenone into solid lipid nanoparticles Pharm. Res. 18 2001 287 293 (Pubitemid 32595815)