Lipid extrudates as novel sustained release systems for pharmaceutical proteins

Journal of Controlled Release

Volumn 134, Issue 3, 2009, Pages 177-185

  Schulze, Sandra ^a   Winter, Gerhard ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Extrusion; Lipid implants; Polyethylene glycol; Protein; Sustained release; Triglycerides

Indexed keywords

EXTRUDATES; FTIR SPECTROSCOPIES; HIGH MELTING; INTERFERON-; LIPID BLENDS; MANUFACTURING STRATEGIES; MODERATE TEMPERATURES; NON-INVASIVE METHODS; PHARMACEUTICAL PROTEINS; PROTEIN RELEASE; PROTEIN STRUCTURES; RELEASE CHARACTERISTICS; RELEASE PROFILES; SDS PAGES; SECONDARY PROTEIN STRUCTURES; SUSTAINED RELEASE; TRIGLYCERIDES; TWIN-SCREW EXTRUSIONS;

DIFFUSERS (OPTICAL); DRUG PRODUCTS; ETHYLENE GLYCOL; FOURIER TRANSFORM INFRARED SPECTROSCOPY; LIPIDS; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; PROTEINS; THERMOPLASTICS;

EXTRUSION;

2 HYDROXYPROPYL BETA CYCLODEXTRIN; LIPID; MACROGOL; RECOMBINANT ALPHA2A INTERFERON; TRIACYLGLYCEROL;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; INFRARED SPECTROSCOPY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN STRUCTURE; RADIATION SCATTERING; SPECTROSCOPY; SUSTAINED RELEASE FORMULATION;

BETA-CYCLODEXTRINS; CALORIMETRY, DIFFERENTIAL SCANNING; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG COMPOUNDING; DRUG IMPLANTS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; INTERFERON ALFA-2A; LIPIDS; POLYETHYLENE GLYCOLS; PROTEIN STABILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TRANSITION TEMPERATURE; X-RAY DIFFRACTION;

EID: 61349173073     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2008.11.026     Document Type: Article

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