Mechanisms controlling protein release from lipidic implants: Effects of PEG addition

Journal of Controlled Release

Volumn 118, Issue 2, 2007, Pages 161-168

  Herrmann, Sandra ^a   Winter, Gerhard ^a   Mohl, Silke ^b   Siepmann, Florence ^c   Siepmann, Juergen ^c  

^a UNIVERSITY OF MUNICH   (Germany)

^b ROCHE DIAGNOSTICS GMBH   (Germany)

^c UNIV LILLE   (France)

Author keywords

Implant; Lipid; PEG; Protein; Release mechanism

Indexed keywords

IMPLANTS (SURGICAL); MASS TRANSFER; OLIGOMERS; POLYETHYLENE GLYCOLS;

CO-LYOPHILISATION AGENT; FICK'S SECOND LAW OF DIFFUSION; RELEASE MECHANISM;

PROTEINS;

2 HYDROXYPROPYL BETA CYCLODEXTRIN; MACROGOL; RECOMBINANT ALPHA2A INTERFERON;

ARTICLE; CYTOKINE RELEASE; DRUG DIFFUSION; DRUG RELEASE; IMPLANT; PRIORITY JOURNAL; PROTEIN SECRETION;

BETA-CYCLODEXTRINS; BUFFERS; CHEMISTRY, PHARMACEUTICAL; DIFFUSION; DRUG CARRIERS; DRUG COMPOUNDING; DRUG IMPLANTS; DRUG STABILITY; EXCIPIENTS; FREEZE DRYING; HUMANS; HYDROGEN-ION CONCENTRATION; INTERFERON ALFA-2A; KINETICS; LIPIDS; MODELS, CHEMICAL; POLYETHYLENE GLYCOLS; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; TRIGLYCERIDES;

EID: 33847341104     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2006.11.001     Document Type: Article

References (30)

1. Cleland J.L. Protein delivery from biodegradable microspheres. Pharm. Biotechnol. 10 (1997) 1-43
2. Putney S.D. Encapsulation of proteins for improved delivery. Curr. Opin. Chem. Biol. 2 (1998) 548-552
3. Sinha V.R., and Trehan A. Biodegradable microspheres for protein delivery. J. Control. Release 90 (2003) 261-280
4. Bittner B., Morlock M., Koll H., Winter G., and Kissel T. Recombinant human erythropoietin (rhEPO) loaded poly(lactide-co-glycolide) microspheres. Influence of the encapsulation technique and polymer purity on microsphere characteristics. Eur. J. Pharm. Biopharm. 45 (1998) 295-305
5. Fu K., Klibanov A.M., and Langer R. Protein stability in controlled-release systems. Nat. Biotech. 18 (2000) 24-25
6. Morlock M., Koll H., Winter G., and Kissel T. Microencapsulation of rh-erythropoietin, using biodegradable poly(d,l-lactide-co-glycolide). Protein stability and the effects of stabilizing excipients. Eur. J. Pharm. Biopharm. 43 (1997) 29-36
7. Schwendeman S.P., Cardamone M., Klibanov A., Langer R., and Brandon M.R. Stability of proteins and their delivery from biodegradable polymer microspheres. Drugs Pharm. Sci. 77 (1996) 1-49
8. van de Weert M., Hennink W.E., and Jiskoot W. Protein instability in poly(lactic-co-glycolic acid) microparticles. Pharm. Res. 17 (2000) 1159-1167
9. Hennink W.E., Talsma H., Borchert J.C.H., De Smedt S.C., and Demeester J. Controlled release of proteins from dextran hydrogels. J. Control. Release 39 (1996) 47-55
10. Cadee J.A., de Groot C.J., Jiskoot W., den Otter W., and Hennink W.E. Release of recombinant human interleukin-2 from dextran-based hydrogels. J. Control. Release 78 (2002) 1-13
11. Pongjanyakul T., Medlicott N.J., and Tucker I.G. Melted glyceryl palmitostearate (GPS) pellets for protein delivery. Int. J. Pharm. 271 (2004) 53-62
12. Reithmeier H., Herrmann J., and Goepferich A. Development and characterization of lipid microparticles as a drug carrier for somatostatin. Int. J. Pharm. 218 (2001) 133-143
13. Vogelhuber W., Magni E., Mouro M., Spruss T., Guse C., Gazzaniga A., and Goepferich A. Monolithic triglyceride matrices: a controlled-release system for proteins. Pharm. Dev. Technol. 8 (2003) 71-79
14. Wang P.Y. Lipids as excipient in sustained release insulin implants. Int. J. Pharm. 54 (1989) 223-230
15. Guse C., Koennings S., Maschke A., Hacker M., Becker C., Schreiner S., Blunk T., Spruss T., and Goepferich A. Biocompatibility and erosion behavior of implants made of triglycerides and blends with cholesterol and phospholipids. Int. J. Pharm. 314 (2006) 153-160
16. Reithmeier H., Herrmann J., and Goepferich A. Lipid microparticles as a parenteral controlled release device for peptides. J. Control. Release 73 (2001) 339-350
17. Vogelhuber W., Magni E., Gazzaniga A., and Goepferich A. Monolithic glyceryl trimyristate matrices for parenteral drug release applications. Eur. J. Pharm. Biopharm. 55 (2003) 133-138
18. Mohl S., and Winter G. Continuous release of rh-interferon alpha-2a from triglyceride matrices. J. Control. Release 97 (2004) 67-78
19. Mohl S., and Winter G. Continuous release of rh-interferon (alpha-2a) from triglyceride implants: storage stability of the dosage forms. Pharm. Dev. Technol. 11 (2006) 103-110
20. Siegel R.A., and Langer R. Controlled release of polypeptides and other macromolecules. Pharm. Res. 1 (1984) 2-10
21. Siegel R.A., Kost J., and Langer R. Mechanistic studies of macromolecular drug release from macroporous polymers. I. Experiments and preliminary theory concerning completeness of drug release. J. Control. Release 8 (1989) 223-236
22. Kaewvichit S., and Tucker I.G. The release of macromolecules from fatty acid matrices: complete factorial study of factors affecting release. J. Pharm. Pharmacol. 46 (1994) 708-713
23. Guse C., Koennings S., Kreye F., Siepmann F., Goepferich A., and Siepmann J. Drug release from lipid-based implants: elucidation of the underlying mass transport mechanisms. Int. J. Pharm. 314 (2006) 137-144
24. Nag A., Mitra G., and Ghosh P.C. A colorimetric assay for estimation of polyethylene glycol and polyethylene glycolated protein using ammonium ferrothiocyanate. Anal. Biochem. 237 (1996) 224-231
25. Basappa C., Pramila R., Narasimha D., and Divakar S.A. A modified colorimetric method for the estimation of b-cyclodextrin using phenolphthalein. Int. J. Food Sci. Technol. 33 (1998) 517-520
26. Irie T., and Uekama K. Cyclodextrins in peptide and protein delivery. Adv. Drug Deliv. Rev. 36 (1999) 101-123
27. Anderson J.S., and Saddington K. The use of radioactive isotopes in the study of diffusion of ions in solution. J. Chem. Soc. Suppl. (1949) 381-386
28. Vergnaud J.M. Controlled Drug Release of Oral Dosage Forms (1993), Ellis Horwood Limited, Chichester
29. Atha D.H., and Ingham K.C. Mechanism of precipitation of proteins by polyethylene glycols: analysis in terms of excluded volume. J. Biol. Chem. 256 (1981) 12108-12117
30. McPherson A. Introduction to protein crystallization. Methods 34 (2004) 254-265