Controlled release of a highly hydrophilic API from lipid microspheres obtained by prilling: Analysis of drug and water diffusion processes with X-ray-based methods

Journal of Controlled Release

Volumn 158, Issue 3, 2012, Pages 393-402

  Pivette, Perrine ^a   Faivre, Vincent ^a   Mancini, Lucia ^b   Gueutin, Claire ^a   Daste, Georges ^c   Ollivon, Michel ^a   Lesieur, Sylviane ^a  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b SINCROTRONE TRIESTE   (Italy)

^c SANOFI   (France)

Author keywords

Diffusion; Microspheres; Microtomography; Prilling; X ray diffraction

Indexed keywords

ANTIEPILEPTIC DRUGS; APPARENT DIFFUSION COEFFICIENT; CONTROLLED RELEASE; DIFFUSION PROCESS; DOSAGE FORMS; DRUG DIFFUSION; DRUG RELEASE; DRUG TRANSPORT; EXPERIMENTAL DATA; FICKIAN DIFFUSION; IN-VITRO; KINETIC ANALYSIS; LIPID BINDERS; LIPID MATRIX; MICROSCOPIC SCALE; MICROTOMOGRAPHY; PRILLING; STRUCTURAL EVOLUTION; SUSTAINED RELEASE; THROUGH CHANNEL; WATER DIFFUSION; WATER DIFFUSION COEFFICIENTS;

DIFFUSION; DIFFUSION IN LIQUIDS; DISSOLUTION; DROP BREAKUP; DRUG PRODUCTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUIDS; MICROSPHERES; RESERVOIRS (WATER); X RAY DIFFRACTION;

DRUG DOSAGE;

MICROSPHERE; VALPROIC ACID; WATER;

AQUEOUS SOLUTION; ARTICLE; CONTROLLED RELEASE FORMULATION; DIFFUSION; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG SOLUBILITY; DRUG TRANSPORT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHILICITY; IN VITRO SELECTION; KINETICS; MICRO-COMPUTED TOMOGRAPHY; PH; PRIORITY JOURNAL; SUSTAINED DRUG RELEASE; WATER IMMERSION; X RAY DIFFRACTION;

ANTICONVULSANTS; DELAYED-ACTION PREPARATIONS; DIFFUSION; DRUG COMPOUNDING; EXCIPIENTS; FATTY ACIDS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MICROSPHERES; PARAFFIN; VALPROIC ACID; WATER; X-RAY DIFFRACTION;

EID: 84859269809     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.11.027     Document Type: Article

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