Distinct Roles for Neutrophils and Dendritic Cells in Inflammation and Autoimmunity in motheaten Mice

Immunity

Volumn 38, Issue 3, 2013, Pages 489-501

  Abram, Clare L ^a   Roberge, Gray L ^a   Pao, Lily I ^b,c   Neel, Benjamin G ^b,d   Lowell, Clifford A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c FIVE PRIME THERAPEUTICS INC   (United States)

^d UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINUCLEAR ANTIBODY; CD86 ANTIGEN; INTEGRIN; INTERLEUKIN 6; KERATINOCYTE DERIVED CHEMOKINE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN KINASE SYK; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE SHP 1; SUPEROXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; BONE MARROW CELL; CELL ACTIVATION; CELL EXPANSION; CHEMICAL ANALYSIS; CONTROLLED STUDY; DENDRITIC CELL; DERMATITIS; EMBRYO DEVELOPMENT; FLOW CYTOMETRY; GENETIC ANALYSIS; GLOMERULONEPHRITIS; IMMUNOBLOTTING; IMMUNOCOMPETENT CELL; INFLAMMATION; INNATE IMMUNITY; LYMPHADENOPATHY; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NEUTROPHIL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SPLEEN CELL; SPLEEN SIZE; SPLENOMEGALY; T LYMPHOCYTE ACTIVATION; UPREGULATION;

ANIMALS; ANTIGENS, CD11C; AUTOIMMUNITY; CALGRANULIN A; CELL LINE, TUMOR; CELLS, CULTURED; DENDRITIC CELLS; DERMIS; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOBLOTTING; INFLAMMATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MUTATION; MYELOID DIFFERENTIATION FACTOR 88; NEUTROPHILS; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 6; PROTEIN-TYROSINE KINASES; SRC-FAMILY KINASES;

EID: 84875532599     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2013.02.018     Document Type: Article

References (42)

1. An H., Hou J., Zhou J., Zhao W., Xu H., Zheng Y., Yu Y., Liu S., Cao X. Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1. Nat. Immunol. 2008, 9:542-550.
2. Chen H.E., Chang S., Trub T., Neel B.G. Regulation of colony-stimulating factor 1 receptor signaling by the SH2 domain-containing tyrosine phosphatase SHPTP1. Mol. Cell. Biol. 1996, 16:3685-3697.
3. Chervonsky A.V. Influence of microbial environment on autoimmunity. Nat. Immunol. 2010, 11:28-35.
4. Croker B.A., Lawson B.R., Rutschmann S., Berger M., Eidenschenk C., Blasius A.L., Moresco E.M., Sovath S., Cengia L., Shultz L.D., et al. Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger. Proc. Natl. Acad. Sci. USA 2008, 105:15028-15033.
5. Croker B.A., Lewis R.S., Babon J.J., Mintern J.D., Jenne D.E., Metcalf D., Zhang J.G., Cengia L.H., O'Donnell J.A., Roberts A.W. Neutrophils require SHP1 to regulate IL-1β production and prevent inflammatory skin disease. J. Immunol. 2011, 186:1131-1139.
6. Dahlgren C., Karlsson A., Bylund J. Measurement of respiratory burst products generated by professional phagocytes. Methods Mol. Biol. 2007, 412:349-363.
7. Fowler C.C., Pao L.I., Blattman J.N., Greenberg P.D. SHP-1 in T cells limits the production of CD8 effector cells without impacting the formation of long-lived central memory cells. J. Immunol. 2010, 185:3256-3267.
8. Green M.C., Shultz L.D. Motheaten, an immunodeficient mutant of the mouse. I. Genetics and pathology. J. Hered. 1975, 66:250-258.
9. Hammer G.E., Turer E.E., Taylor K.E., Fang C.J., Advincula R., Oshima S., Barrera J., Huang E.J., Hou B., Malynn B.A., et al. Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis. Nat. Immunol. 2011, 12:1184-1193.
10. Hardin A.O., Meals E.A., Yi T., Knapp K.M., English B.K. SHP-1 inhibits LPS-mediated TNF and iNOS production in murine macrophages. Biochem. Biophys. Res. Commun. 2006, 342:547-555.
11. Jiao H., Yang W., Berrada K., Tabrizi M., Shultz L., Yi T. Macrophages from motheaten and viable motheaten mutant mice show increased proliferative responses to GM-CSF: detection of potential HCP substrates in GM-CSF signal transduction. Exp. Hematol. 1997, 25:592-600.
12. Kaneko T., Saito Y., Kotani T., Okazawa H., Iwamura H., Sato-Hashimoto M., Kanazawa Y., Takahashi S., Hiromura K., Kusakari S., et al. Dendritic cell-specific ablation of the protein tyrosine phosphatase Shp1 promotes Th1 cell differentiation and induces autoimmunity. J. Immunol. 2012, 188:5397-5407.
13. Koo G.C., Rosen H., Sirotina A., Ma X.D., Shultz L.D. Anti-CD11b antibody prevents immunopathologic changes in viable moth-eaten bone marrow chimeric mice. J. Immunol. 1993, 151:6733-6741.
14. Kool M., van Loo G., Waelput W., De Prijck S., Muskens F., Sze M., van Praet J., Branco-Madeira F., Janssens S., Reizis B., et al. The ubiquitin-editing protein A20 prevents dendritic cell activation, recognition of apoptotic cells, and systemic autoimmunity. Immunity 2011, 35:82-96.
15. Kruger J., Butler J.R., Cherapanov V., Dong Q., Ginzberg H., Govindarajan A., Grinstein S., Siminovitch K.A., Downey G.P. Deficiency of Src homology 2-containing phosphatase 1 results in abnormalities in murine neutrophil function: studies in motheaten mice. J. Immunol. 2000, 165:5847-5859.
16. Kuntz L., Fonteneau P., Loor F. Partial expression of the viable motheaten (mev) mutation in the heterozygous state: abnormal levels of serum immunoglobulins and natural anti-ssDNA antibodies. J. Autoimmun. 1990, 3:329-335.
17. Looney M.R., Nguyen J.X., Hu Y., Van Ziffle J.A., Lowell C.A., Matthay M.A. Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury. J. Clin. Invest. 2009, 119:3450-3461.
18. Lorenz U., Bergemann A.D., Steinberg H.N., Flanagan J.G., Li X., Galli S.J., Neel B.G. Genetic analysis reveals cell type-specific regulation of receptor tyrosine kinase c-Kit by the protein tyrosine phosphatase SHP1. J. Exp. Med. 1996, 184:1111-1126.
19. Marshak-Rothstein A. Toll-like receptors in systemic autoimmune disease. Nat. Rev. Immunol. 2006, 6:823-835.
20. Mócsai A., Zhou M., Meng F., Tybulewicz V.L., Lowell C.A. Syk is required for integrin signaling in neutrophils. Immunity 2002, 16:547-558.
21. Mócsai A., Abram C.L., Jakus Z., Hu Y., Lanier L.L., Lowell C.A. Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs. Nat. Immunol. 2006, 7:1326-1333.
22. Neel B.G., Gu H., Pao L. The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling. Trends Biochem. Sci. 2003, 28:284-293.
23. Nesterovitch A.B., Szanto S., Gonda A., Bardos T., Kis-Toth K., Adarichev V.A., Olasz K., Ghassemi-Najad S., Hoffman M.D., Tharp M.D., et al. Spontaneous insertion of a b2 element in the ptpn6 gene drives a systemic autoinflammatory disease in mice resembling neutrophilic dermatosis in humans. Am. J. Pathol. 2011, 178:1701-1714.
24. Nesterovitch A.B., Gyorfy Z., Hoffman M.D., Moore E.C., Elbuluk N., Tryniszewska B., Rauch T.A., Simon M., Kang S., Fisher G.J., et al. Alteration in the gene encoding protein tyrosine phosphatase nonreceptor type 6 (PTPN6/SHP1) may contribute to neutrophilic dermatoses. Am. J. Pathol. 2011, 178:1434-1441.
25. Oh S.Y., Zheng T., Kim Y.K., Cohn L., Homer R.J., McKenzie A.N., Zhu Z. A critical role of SHP-1 in regulation of type 2 inflammation in the lung. Am. J. Respir. Cell Mol. Biol. 2009, 40:568-574.
26. Pao L.I., Badour K., Siminovitch K.A., Neel B.G. Nonreceptor protein-tyrosine phosphatases in immune cell signaling. Annu. Rev. Immunol. 2007, 25:473-523.
27. Pao L.I., Lam K.P., Henderson J.M., Kutok J.L., Alimzhanov M., Nitschke L., Thomas M.L., Neel B.G., Rajewsky K. B cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunity. Immunity 2007, 27:35-48.
28. Paulson R.F., Vesely S., Siminovitch K.A., Bernstein A. Signalling by the W/Kit receptor tyrosine kinase is negatively regulated in vivo by the protein tyrosine phosphatase Shp1. Nat. Genet. 1996, 13:309-315.
29. Pereira S., Lowell C. The Lyn tyrosine kinase negatively regulates neutrophil integrin signaling. J. Immunol. 2003, 171:1319-1327.
30. Ramachandran I.R., Song W., Lapteva N., Seethammagari M., Slawin K.M., Spencer D.M., Levitt J.M. The phosphatase SRC homology region 2 domain-containing phosphatase-1 is an intrinsic central regulator of dendritic cell function. J. Immunol. 2011, 186:3934-3945.
31. Rego D., Kumar A., Nilchi L., Wright K., Huang S., Kozlowski M. IL-6 production is positively regulated by two distinct Src homology domain 2-containing tyrosine phosphatase-1 (SHP-1)-dependent CCAAT/enhancer-binding protein β and NF-κB pathways and an SHP-1-independent NF-κB pathway in lipopolysaccharide-stimulated bone marrow-derived macrophages. J. Immunol. 2011, 186:5443-5456.
32. Roach T.I., Slater S.E., White L.S., Zhang X., Majerus P.W., Brown E.J., Thomas M.L. The protein tyrosine phosphatase SHP-1 regulates integrin-mediated adhesion of macrophages. Curr. Biol. 1998, 8:1035-1038.
33. Shultz L.D., Coman D.R., Bailey C.L., Beamer W.G., Sidman C.L. " Viable motheaten," a new allele at the motheaten locus. I. Pathology. Am. J. Pathol. 1984, 116:179-192.
34. Shultz L.D., Rajan T.V., Greiner D.L. Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiency. Trends Biotechnol. 1997, 15:302-307.
35. Siemsen D.W., Schepetkin I.A., Kirpotina L.N., Lei B., Quinn M.T. Neutrophil isolation from nonhuman species. Methods Mol. Biol. 2007, 412:21-34.
36. Suen P.W., Ilic D., Caveggion E., Berton G., Damsky C.H., Lowell C.A. Impaired integrin-mediated signal transduction, altered cytoskeletal structure and reduced motility in Hck/Fgr deficient macrophages. J. Cell Sci. 1999, 112:4067-4078.
37. Timms J.F., Carlberg K., Gu H., Chen H., Kamatkar S., Nadler M.J., Rohrschneider L.R., Neel B.G. Identification of major binding proteins and substrates for the SH2-containing protein tyrosine phosphatase SHP-1 in macrophages. Mol. Cell. Biol. 1998, 18:3838-3850.
38. Tsui F.W., Martin A., Wang J., Tsui H.W. Investigations into the regulation and function of the SH2 domain-containing protein-tyrosine phosphatase, SHP-1. Immunol. Res. 2006, 35:127-136.
39. Yu C.C., Tsui H.W., Ngan B.Y., Shulman M.J., Wu G.E., Tsui F.W. B and T cells are not required for the viable motheaten phenotype. J. Exp. Med. 1996, 183:371-380.
40. Zhang J., Somani A.K., Siminovitch K.A. Roles of the SHP-1 tyrosine phosphatase in the negative regulation of cell signalling. Semin. Immunol. 2000, 12:361-378.
41. Zhang L., Oh S.Y., Wu X., Oh M.H., Wu F., Schroeder J.T., Takemoto C.M., Zheng T., Zhu Z. SHP-1 deficient mast cells are hyperresponsive to stimulation and critical in initiating allergic inflammation in the lung. J. Immunol. 2010, 184:1180-1190.
42. Zhou D., Collins C.A., Wu P., Brown E.J. Protein tyrosine phosphatase SHP-1 positively regulates TLR-induced IL-12p40 production in macrophages through inhibition of phosphatidylinositol 3-kinase. J. Leukoc. Biol. 2010, 87:845-855.