A staphylococcus aureus TIR domain protein virulence factor blocks TLR2-mediated NF-κB signaling

Journal of Innate Immunity

Volumn 6, Issue 4, 2014, Pages 485-498

  Askarian, Fatemeh ^a   Van Sorge, Nina M ^c   Sangvik, Maria ^a   Beasley, Federico C ^d   Henriksen, Jørn R ^b   Sollid, Johanna U E ^a   Van Strijp, Jos A G ^c   Nizet, Victor ^d   Johannessen, Mona ^a  

^a UNIVERSITY OF TROMSØ   (Norway)

^b Arcticzymes   (Norway)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Bacterial TIR domain; Mitogen activated protein kinase; NF B; Staphylococcal TIR domain protein; Staphylococcus aureus; TirS; TLR signaling

Indexed keywords

CYTOKINE; GRANULOCYTE COLONY STIMULATING FACTOR; I KAPPA B; INTERLEUKIN 1 RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 2; VIRULENCE FACTOR; BACTERIAL PROTEIN; CCL2 PROTEIN, HUMAN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MEMBRANE PROTEIN; TICAM1 PROTEIN, HUMAN; TIR DOMAIN PROTEIN, STAPHYLOCOCCUS AUREUS; TIRAP PROTEIN, HUMAN; VESICULAR TRANSPORT ADAPTOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL SURVIVAL; BACTERIAL VIRULENCE; CONTROLLED STUDY; CYTOKINE RELEASE; DATA BASE; EMBRYO; FEMALE; GENETIC ANALYSIS; HOST CELL; HOST RESISTANCE; HUMAN; HUMAN CELL; IMMUNE EVASION; INFECTION; INNATE IMMUNITY; KERATINOCYTE; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; SKIN ABSCESS; STAPHYLOCOCCUS AUREUS; WILD TYPE; AMINO ACID SEQUENCE; ANIMAL; BACTERIAL LOAD; C57BL MOUSE; CELL LINE; DISEASE MODEL; GENETICS; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; MOLECULAR GENETICS; MUTATION; PATHOGENICITY; SEQUENCE HOMOLOGY; STAPHYLOCOCCUS INFECTION; CELL STIMULATION; IMMUNE RESPONSE; KIDNEY CELL; PROTEIN EXPRESSION;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; AMINO ACID SEQUENCE; ANIMALS; BACTERIAL LOAD; BACTERIAL PROTEINS; CELL LINE; CHEMOKINE CCL2; DISEASE MODELS, ANIMAL; FEMALE; GRANULOCYTE COLONY-STIMULATING FACTOR; HUMANS; IMMUNE EVASION; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; MUTATION; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; RECEPTORS, INTERLEUKIN-1; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; TOLL-LIKE RECEPTOR 2; VIRULENCE FACTORS;

EID: 84902821133     PISSN: 1662811X     EISSN: 16628128     Source Type: Journal    
DOI: 10.1159/000357618     Document Type: Article

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