-
1
-
-
32944464648
-
Pathogen recognition and innate immunity
-
16497588 10.1016/j.cell.2006.02.015 1:CAS:528:DC%2BD28Xit1Kltb8%3D
-
Akira S, Uematsu S, Takeuchi O (2006) Pathogen recognition and innate immunity. Cell 124:783-801
-
(2006)
Cell
, vol.124
, pp. 783-801
-
-
Akira, S.1
Uematsu, S.2
Takeuchi, O.3
-
2
-
-
34247254780
-
Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity
-
17433730 10.1016/j.immuni.2007.03.009 1:CAS:528:DC%2BD2sXltVKjs74%3D
-
Fritz JH, Le Bourhis L, Sellge G, Magalhaes JG, Fsihi H, Kufer TA, Collins C, Viala J, Ferrero RL, Girardin SE et al (2007) Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity. Immunity 26:445-459
-
(2007)
Immunity
, vol.26
, pp. 445-459
-
-
Fritz, J.H.1
Le Bourhis, L.2
Sellge, G.3
Magalhaes, J.G.4
Fsihi, H.5
Kufer, T.A.6
Collins, C.7
Viala, J.8
Ferrero, R.L.9
Girardin, S.E.10
-
3
-
-
65649141586
-
Pathogen recognition in the innate immune response
-
19382893 10.1042/BJ20090272 1:CAS:528:DC%2BD1MXltFCjsLo%3D
-
Kumar H, Kawai T, Akira S (2009) Pathogen recognition in the innate immune response. Biochem J 420:1-16
-
(2009)
Biochem J
, vol.420
, pp. 1-16
-
-
Kumar, H.1
Kawai, T.2
Akira, S.3
-
4
-
-
34548459868
-
Structure and function of Toll receptors and their ligands
-
17362201 10.1146/annurev.biochem.76.060305.151318 1:CAS:528: DC%2BD2sXhtVehtb7J
-
Gay NJ, Gangloff M (2007) Structure and function of Toll receptors and their ligands. Annu Rev Biochem 76:141-165
-
(2007)
Annu Rev Biochem
, vol.76
, pp. 141-165
-
-
Gay, N.J.1
Gangloff, M.2
-
5
-
-
3142724031
-
Toll-like receptor signalling
-
15229469 10.1038/nri1391 1:CAS:528:DC%2BD2cXlt1Cqur0%3D
-
Akira S, Takeda K (2004) Toll-like receptor signalling. Nat Rev Immunol 4:499-511
-
(2004)
Nat Rev Immunol
, vol.4
, pp. 499-511
-
-
Akira, S.1
Takeda, K.2
-
6
-
-
0024299087
-
The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein
-
2449285 10.1016/0092-8674(88)90516-8 1:CAS:528:DyaL1MXitVKrtrc%3D
-
Hashimoto C, Hudson KL, Anderson KV (1988) The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein. Cell 52:269-279
-
(1988)
Cell
, vol.52
, pp. 269-279
-
-
Hashimoto, C.1
Hudson, K.L.2
Anderson, K.V.3
-
7
-
-
0025774776
-
Drosophila Toll and IL-1 receptor
-
1851964 10.1038/351355b0 1:STN:280:DyaK3M3jvV2lsQ%3D%3D
-
Gay NJ, Keith FJ (1991) Drosophila Toll and IL-1 receptor. Nature 351:355-356
-
(1991)
Nature
, vol.351
, pp. 355-356
-
-
Gay, N.J.1
Keith, F.J.2
-
8
-
-
33750070631
-
Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting
-
16880211 10.1074/jbc.M602794200 1:CAS:528:DC%2BD28XhtVCrsLbK
-
Triantafilou M, Gamper FGJ, Haston RM, Mouratis MA, Morath S, Hartung T, Triantafilou K (2006) Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting. J Biol Chem 281:31002-31011
-
(2006)
J Biol Chem
, vol.281
, pp. 31002-31011
-
-
Triantafilou, M.1
Gamper, F.G.J.2
Haston, R.M.3
Mouratis, M.A.4
Morath, S.5
Hartung, T.6
Triantafilou, K.7
-
9
-
-
34250698370
-
Ligand-induced conformational changes allosterically activate Toll-like receptor 9
-
17572678 10.1038/ni1479 1:CAS:528:DC%2BD2sXms1Wgur4%3D
-
Latz E, Verma A, Visintin A, Gong M, Sirois CM, Klein DCG, Monks BG, McKnight CJ, Lamphier MS, Duprex WP et al (2007) Ligand-induced conformational changes allosterically activate Toll-like receptor 9. Nat Immunol 8:772-779
-
(2007)
Nat Immunol
, vol.8
, pp. 772-779
-
-
Latz, E.1
Verma, A.2
Visintin, A.3
Gong, M.4
Sirois, C.M.5
Klein, D.C.G.6
Monks, B.G.7
McKnight, C.J.8
Lamphier, M.S.9
Duprex, W.P.10
-
10
-
-
34247566510
-
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
-
17457343 10.1038/nri2079
-
O'Neill LAJ, Bowie AG (2007) The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol 7:353-364
-
(2007)
Nat Rev Immunol
, vol.7
, pp. 353-364
-
-
O'Neill, L.A.J.1
Bowie, A.G.2
-
11
-
-
40749097627
-
A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins
-
17726518 10.1371/journal.pone.0000788
-
Núñez Miguel R, Wong J, Westoll JF, Brooks HJ, O'Neill LAJ, Gay NJ, Bryant CE, Monie TP (2007) A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins. PLoS One 2:e788
-
(2007)
PLoS One
, vol.2
, pp. 788
-
-
Núñez Miguel, R.1
Wong, J.2
Westoll, J.F.3
Brooks, H.J.4
O'Neill, L.A.J.5
Gay, N.J.6
Bryant, C.E.7
Monie, T.P.8
-
12
-
-
33644935846
-
Binding specificity of Toll-like receptor cytoplasmic domains
-
16482509 10.1002/eji.200535158 1:CAS:528:DC%2BD28XjtVegt7k%3D
-
Brown V, Brown RA, Ozinsky A, Hesselberth JR, Fields S (2006) Binding specificity of Toll-like receptor cytoplasmic domains. Eur J Immunol 36:742-753
-
(2006)
Eur J Immunol
, vol.36
, pp. 742-753
-
-
Brown, V.1
Brown, R.A.2
Ozinsky, A.3
Hesselberth, J.R.4
Fields, S.5
-
13
-
-
0037153130
-
The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors
-
12447442 10.1038/nature01180 1:CAS:528:DC%2BD38XovVekt7c%3D
-
Horng T, Barton GM, Flavell RA, Medzhitov R (2002) The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature 420:329-333
-
(2002)
Nature
, vol.420
, pp. 329-333
-
-
Horng, T.1
Barton, G.M.2
Flavell, R.A.3
Medzhitov, R.4
-
14
-
-
33646567507
-
The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction
-
16603631 10.1073/pnas.0510041103 1:CAS:528:DC%2BD28XktFamsbo%3D
-
Rowe DC, McGettrick AF, Latz E, Monks BG, Gay NJ, Yamamoto M, Akira S, O'Neill LA, Fitzgerald KA, Golenbock DT (2006) The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction. Proc Natl Acad Sci USA 103:6299-6304
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 6299-6304
-
-
Rowe, D.C.1
McGettrick, A.F.2
Latz, E.3
Monks, B.G.4
Gay, N.J.5
Yamamoto, M.6
Akira, S.7
O'Neill, L.A.8
Fitzgerald, K.A.9
Golenbock, D.T.10
-
15
-
-
33748871187
-
The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling
-
16964262 10.1038/ni1382 1:CAS:528:DC%2BD28Xps1yntbk%3D
-
Carty M, Goodbody R, Schröder M, Stack J, Moynagh PN, Bowie AG (2006) The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling. Nat Immunol 7:1074-1081
-
(2006)
Nat Immunol
, vol.7
, pp. 1074-1081
-
-
Carty, M.1
Goodbody, R.2
Schröder, M.3
Stack, J.4
Moynagh, P.N.5
Bowie, A.G.6
-
16
-
-
3843055773
-
Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL
-
15123616 10.1074/jbc.M403434200 1:CAS:528:DC%2BD2cXlslOrt74%3D
-
Khan JA, Brint EK, O'Neill LAJ, Tong L (2004) Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL. J Biol Chem 279:31664-31670
-
(2004)
J Biol Chem
, vol.279
, pp. 31664-31670
-
-
Khan, J.A.1
Brint, E.K.2
O'Neill, L.A.J.3
Tong, L.4
-
17
-
-
0034681434
-
Identification of two major sites in the type i interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways
-
10671496 10.1074/jbc.275.7.4670 1:CAS:528:DC%2BD3cXhsVynurs%3D
-
Slack JL, Schooley K, Bonnert TP, Mitcham JL, Qwarnstrom EE, Sims JE, Dower SK (2000) Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways. J Biol Chem 275:4670-4678
-
(2000)
J Biol Chem
, vol.275
, pp. 4670-4678
-
-
Slack, J.L.1
Schooley, K.2
Bonnert, T.P.3
Mitcham, J.L.4
Qwarnstrom, E.E.5
Sims, J.E.6
Dower, S.K.7
-
18
-
-
0032509295
-
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
-
9851930 10.1126/science.282.5396.2085 1:CAS:528:DyaK1cXotVyjsbk%3D
-
Poltorak A, He X, Smirnova I, Liu MY, van Huffel C, Du X, Birdwell D, Alejos E, Silva M, Galanos C et al (1998) Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282:2085-2088
-
(1998)
Science
, vol.282
, pp. 2085-2088
-
-
Poltorak, A.1
He, X.2
Smirnova, I.3
Liu, M.Y.4
Van Huffel, C.5
Du, X.6
Birdwell, D.7
Alejos, E.8
Silva, M.9
Galanos, C.10
-
19
-
-
0034597766
-
Structural basis for signal transduction by the Toll/interleukin-1 receptor domains
-
11081518 10.1038/35047056 1:CAS:528:DC%2BD3cXotVaksLc%3D
-
Xu Y, Tao X, Shen B, Horng T, Medzhitov R, Manley JL, Tong L (2000) Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. Nature 408:111-115
-
(2000)
Nature
, vol.408
, pp. 111-115
-
-
Xu, Y.1
Tao, X.2
Shen, B.3
Horng, T.4
Medzhitov, R.5
Manley, J.L.6
Tong, L.7
-
20
-
-
45549086115
-
The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer
-
18332149 10.1074/jbc.C800001200 1:CAS:528:DC%2BD1cXltVyku78%3D
-
Nyman T, Stenmark P, Flodin S, Johansson I, Hammarström M, Nordlund P (2008) The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer. J Biol Chem 283:11861-11865
-
(2008)
J Biol Chem
, vol.283
, pp. 11861-11865
-
-
Nyman, T.1
Stenmark, P.2
Flodin, S.3
Johansson, I.4
Hammarström, M.5
Nordlund, P.6
-
21
-
-
67649865588
-
Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling
-
19506249 10.1073/pnas.0812956106 1:CAS:528:DC%2BD1MXot1Cmsbg%3D
-
Ohnishi H, Tochio H, Kato Z, Orii KE, Li A, Kimura T, Hiroaki H, Kondo N, Shirakawa M (2009) Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling. Proc Natl Acad Sci USA 106:10260-10265
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 10260-10265
-
-
Ohnishi, H.1
Tochio, H.2
Kato, Z.3
Orii, K.E.4
Li, A.5
Kimura, T.6
Hiroaki, H.7
Kondo, N.8
Shirakawa, M.9
-
22
-
-
80052578340
-
Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection
-
21873236 10.1073/pnas.1104780108 1:CAS:528:DC%2BC3MXhtFyktb7M
-
Valkov E, Stamp A, Dimaio F, Baker D, Verstak B, Roversi P, Kellie S, Sweet MJ, Mansell A, Gay NJ et al (2011) Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection. Proc Natl Acad Sci USA 108:14879-14884
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 14879-14884
-
-
Valkov, E.1
Stamp, A.2
Dimaio, F.3
Baker, D.4
Verstak, B.5
Roversi, P.6
Kellie, S.7
Sweet, M.J.8
Mansell, A.9
Gay, N.J.10
-
23
-
-
34548459895
-
Structure, function and regulation of the Toll/IL-1 receptor adaptor proteins
-
17667936 10.1038/sj.icb.7100095 1:CAS:528:DC%2BD2sXpvFWgtbg%3D
-
Watters TM, Kenny EF, O'Neill LAJ (2007) Structure, function and regulation of the Toll/IL-1 receptor adaptor proteins. Immunol Cell Biol 85:411-419
-
(2007)
Immunol Cell Biol
, vol.85
, pp. 411-419
-
-
Watters, T.M.1
Kenny, E.F.2
O'Neill, L.A.J.3
-
24
-
-
0036073290
-
Modification of the structure and activity of lipid A in Yersinia pestis lipopolysaccharide by growth temperature
-
12117916 10.1128/IAI.70.8.4092-4098.2002 1:CAS:528:DC%2BD38XlsFCmsb8%3D
-
Kawahara K, Tsukano H, Watanabe H, Lindner B, Matsuura M (2002) Modification of the structure and activity of lipid A in Yersinia pestis lipopolysaccharide by growth temperature. Infect Immun 70:4092-4098
-
(2002)
Infect Immun
, vol.70
, pp. 4092-4098
-
-
Kawahara, K.1
Tsukano, H.2
Watanabe, H.3
Lindner, B.4
Matsuura, M.5
-
25
-
-
0035876915
-
Mannosylated lipoarabinomannans inhibit IL-12 production by human dendritic cells: Evidence for a negative signal delivered through the mannose receptor
-
11390501 1:CAS:528:DC%2BD3MXksVOms78%3D
-
Nigou J, Zelle-Rieser C, Gilleron M, Thurnher M, Puzo G (2001) Mannosylated lipoarabinomannans inhibit IL-12 production by human dendritic cells: evidence for a negative signal delivered through the mannose receptor. J Immunol 166:7477-7485
-
(2001)
J Immunol
, vol.166
, pp. 7477-7485
-
-
Nigou, J.1
Zelle-Rieser, C.2
Gilleron, M.3
Thurnher, M.4
Puzo, G.5
-
26
-
-
17144366260
-
Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence
-
15767367 10.1084/jem.20041442 1:CAS:528:DC%2BD2MXislOhu7c%3D
-
Stack J, Haga IR, Schröder M, Bartlett NW, Maloney G, Reading PC, Fitzgerald KA, Smith GL, Bowie AG (2005) Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence. J Exp Med 201:1007-1018
-
(2005)
J Exp Med
, vol.201
, pp. 1007-1018
-
-
Stack, J.1
Haga, I.R.2
Schröder, M.3
Bartlett, N.W.4
Maloney, G.5
Reading, P.C.6
Fitzgerald, K.A.7
Smith, G.L.8
Bowie, A.G.9
-
27
-
-
0034730146
-
A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling
-
10920188 10.1073/pnas.160027697 1:CAS:528:DC%2BD3cXmtlehtrs%3D
-
Bowie A, Kiss-Toth E, Symons JA, Smith GL, Dower SK, O'Neill LA (2000) A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling. Proc Natl Acad Sci USA 97:10162-10167
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 10162-10167
-
-
Bowie, A.1
Kiss-Toth, E.2
Symons, J.A.3
Smith, G.L.4
Dower, S.K.5
O'Neill, L.A.6
-
28
-
-
0037415598
-
The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defense
-
12566418 10.1084/jem.20021652 1:CAS:528:DC%2BD3sXhtVWms7o%3D
-
Harte MT, Haga IR, Maloney G, Gray P, Reading PC, Bartlett NW, Smith GL, Bowie A, O'Neill LAJ (2003) The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defense. J Exp Med 197:343-351
-
(2003)
J Exp Med
, vol.197
, pp. 343-351
-
-
Harte, M.T.1
Haga, I.R.2
Maloney, G.3
Gray, P.4
Reading, P.C.5
Bartlett, N.W.6
Smith, G.L.7
Bowie, A.8
O'Neill, L.A.J.9
-
29
-
-
69749101103
-
Microbial TIR domains: Not necessarily agents of subversion?
-
19716705 10.1016/j.tim.2009.06.005 1:CAS:528:DC%2BD1MXhtFajtrnK
-
Spear AM, Loman NJ, Atkins HS, Pallen MJ (2009) Microbial TIR domains: not necessarily agents of subversion? Trends Microbiol 17:393-398
-
(2009)
Trends Microbiol
, vol.17
, pp. 393-398
-
-
Spear, A.M.1
Loman, N.J.2
Atkins, H.S.3
Pallen, M.J.4
-
30
-
-
80052444371
-
The Hepatitis B e antigen (HBeAg) targets and suppresses activation of the Toll-like receptor signaling pathway
-
doi: 10.1016/j.jhep.2010.12.042
-
Lang T, Lo C, Skinner N, Locarnini S, Visvanathan K, Mansell A (2011) The Hepatitis B e antigen (HBeAg) targets and suppresses activation of the Toll-like receptor signaling pathway. J Hepatol. doi: 10.1016/j.jhep.2010.12.042
-
(2011)
J Hepatol
-
-
Lang, T.1
Lo, C.2
Skinner, N.3
Locarnini, S.4
Visvanathan, K.5
Mansell, A.6
-
31
-
-
79953156757
-
Kaposi sarcoma-associated herpesvirus degrades cellular Toll-interleukin-1 receptor domain-containing adaptor-inducing beta-interferon (TRIF)
-
21212282 10.1074/jbc.M110.191452 1:CAS:528:DC%2BC3MXislylsLk%3D
-
Ahmad H, Gubbels R, Ehlers E, Meyer F, Waterbury T, Lin R, Zhang L (2011) Kaposi sarcoma-associated herpesvirus degrades cellular Toll-interleukin-1 receptor domain-containing adaptor-inducing beta-interferon (TRIF). J Biol Chem 286:7865-7872
-
(2011)
J Biol Chem
, vol.286
, pp. 7865-7872
-
-
Ahmad, H.1
Gubbels, R.2
Ehlers, E.3
Meyer, F.4
Waterbury, T.5
Lin, R.6
Zhang, L.7
-
32
-
-
29644438009
-
Identification and characterization of a novel bacterial virulence factor that shares homology with mammalian Toll/interleukin-1 receptor family proteins
-
16369016 10.1128/IAI.74.1.594-601.2006 1:CAS:528:DC%2BD28XitlKrtw%3D%3D
-
Newman RM, Salunkhe P, Godzik A, Reed JC (2006) Identification and characterization of a novel bacterial virulence factor that shares homology with mammalian Toll/interleukin-1 receptor family proteins. Infect Immun 74:594-601
-
(2006)
Infect Immun
, vol.74
, pp. 594-601
-
-
Newman, R.M.1
Salunkhe, P.2
Godzik, A.3
Reed, J.C.4
-
33
-
-
33947356714
-
Characterization of a TIR-like protein from Paracoccus denitrificans
-
17362878 10.1016/j.bbrc.2007.03.003 1:CAS:528:DC%2BD2sXjsVGitrc%3D
-
Low LY, Mukasa T, Reed JC, Pascual J (2007) Characterization of a TIR-like protein from Paracoccus denitrificans. Biochem Biophys Res Comm 356:481-486
-
(2007)
Biochem Biophys Res Comm
, vol.356
, pp. 481-486
-
-
Low, L.Y.1
Mukasa, T.2
Reed, J.C.3
Pascual, J.4
-
34
-
-
41849102701
-
Subversion of Toll-like receptor signaling by a unique family of bacterial Toll/interleukin-1 receptor domain-containing proteins
-
18327267 10.1038/nm1734 1:CAS:528:DC%2BD1cXktl2isL4%3D
-
Cirl C, Wieser A, Yadav M, Duerr S, Schubert S, Fischer H, Stappert D, Wantia N, Rodriguez N, Wagner H et al (2008) Subversion of Toll-like receptor signaling by a unique family of bacterial Toll/interleukin-1 receptor domain-containing proteins. Nat Med 14:399-406
-
(2008)
Nat Med
, vol.14
, pp. 399-406
-
-
Cirl, C.1
Wieser, A.2
Yadav, M.3
Duerr, S.4
Schubert, S.5
Fischer, H.6
Stappert, D.7
Wantia, N.8
Rodriguez, N.9
Wagner, H.10
-
35
-
-
79951943072
-
TIR domain-containing adaptor SARM is a late addition to the ongoing microbe-host dialog
-
10.1016/j.dci.2010.11.013 1:CAS:528:DC%2BC3MXisFKgtLs%3D
-
Zhang Q, Zmasek CM, Cai X, Godzik A (2011) TIR domain-containing adaptor SARM is a late addition to the ongoing microbe-host dialog. Develop Comp Immunol 35:461-468
-
(2011)
Develop Comp Immunol
, vol.35
, pp. 461-468
-
-
Zhang, Q.1
Zmasek, C.M.2
Cai, X.3
Godzik, A.4
-
36
-
-
65649148280
-
Brucella TIR domain-containing protein mimics properties of the Toll-like receptor adaptor protein TIRAP
-
19196716 10.1074/jbc.M805458200 1:CAS:528:DC%2BD1MXjvFKrs78%3D
-
Radhakrishnan GK, Yu Q, Harms JS, Splitter GA (2009) Brucella TIR domain-containing protein mimics properties of the Toll-like receptor adaptor protein TIRAP. J Biol Chem 284:9892-9898
-
(2009)
J Biol Chem
, vol.284
, pp. 9892-9898
-
-
Radhakrishnan, G.K.1
Yu, Q.2
Harms, J.S.3
Splitter, G.A.4
-
37
-
-
78149312293
-
Inhibition of TIR domain signaling by TcpC: MyD88-dependent and independent effects on Escherichia coli virulence
-
20886104 10.1371/journal.ppat.1001120
-
Yadav M, Zhang J, Fischer H, Huang W, Lutay N, Cirl C, Lum J, Miethke T, Svanborg C (2010) Inhibition of TIR domain signaling by TcpC: MyD88-dependent and independent effects on Escherichia coli virulence. PLoS Pathog 6:e1001120
-
(2010)
PLoS Pathog
, vol.6
, pp. 1001120
-
-
Yadav, M.1
Zhang, J.2
Fischer, H.3
Huang, W.4
Lutay, N.5
Cirl, C.6
Lum, J.7
Miethke, T.8
Svanborg, C.9
-
38
-
-
76249100903
-
Subversion of innate immune responses by Brucella through the targeted degradation of the TLR signaling adapter, MAL
-
20018612 10.4049/jimmunol.0902008 1:CAS:528:DC%2BC3cXhslCkug%3D%3D
-
Sengupta D, Koblansky A, Gaines J, Brown T, West AP, Zhang D, Nishikawa T, Park S-G, Roop RM, Ghosh S (2010) Subversion of innate immune responses by Brucella through the targeted degradation of the TLR signaling adapter, MAL. J Immunol 184:956-964
-
(2010)
J Immunol
, vol.184
, pp. 956-964
-
-
Sengupta, D.1
Koblansky, A.2
Gaines, J.3
Brown, T.4
West, A.P.5
Zhang, D.6
Nishikawa, T.7
Park, S.-G.8
Roop, R.M.9
Ghosh, S.10
-
39
-
-
40349103656
-
Brucella control of dendritic cell maturation is dependent on the TIR-containing protein Btp1
-
18266466 10.1371/journal.ppat.0040021
-
Salcedo SP, Marchesini MI, Lelouard H, Fugier E, Jolly G, Balor S, Muller A, Lapaque N, Demaria O, Alexopoulou L et al (2008) Brucella control of dendritic cell maturation is dependent on the TIR-containing protein Btp1. PLoS Pathog 4:e21
-
(2008)
PLoS Pathog
, vol.4
, pp. 21
-
-
Salcedo, S.P.1
Marchesini, M.I.2
Lelouard, H.3
Fugier, E.4
Jolly, G.5
Balor, S.6
Muller, A.7
Lapaque, N.8
Demaria, O.9
Alexopoulou, L.10
-
40
-
-
84861899161
-
A TIR domain protein from Yersinia pestis interacts with mammalian IL-1/TLR pathways but does not play a central role in the virulence of Y. pestis in a mouse model of bubonic plague
-
22403187 10.1099/mic.0.055012-0 1:CAS:528:DC%2BC38XhtVertbnL
-
Spear AM, Rana R, Jenner DC, Flick-Smith HC, Oyston PCF, Simpson P, Matthews S, Byrne B, Atkins HS (2012) A TIR domain protein from Yersinia pestis interacts with mammalian IL-1/TLR pathways but does not play a central role in the virulence of Y. pestis in a mouse model of bubonic plague. Microbiology 158:1593-1606
-
(2012)
Microbiology
, vol.158
, pp. 1593-1606
-
-
Spear, A.M.1
Rana, R.2
Jenner, D.C.3
Flick-Smith, H.C.4
Oyston, P.C.F.5
Simpson, P.6
Matthews, S.7
Byrne, B.8
Atkins, H.S.9
-
41
-
-
20444413447
-
Inhibition of MAPK and NF-kappa B pathways is necessary for rapid apoptosis in macrophages infected with Yersinia
-
15944300 1:CAS:528:DC%2BD2MXkvVOlsrw%3D
-
Zhang Y, Ting AT, Marcu KB, Bliska JB (2005) Inhibition of MAPK and NF-kappa B pathways is necessary for rapid apoptosis in macrophages infected with Yersinia. J Immunol 174:7939-7949
-
(2005)
J Immunol
, vol.174
, pp. 7939-7949
-
-
Zhang, Y.1
Ting, A.T.2
Marcu, K.B.3
Bliska, J.B.4
-
42
-
-
69249159463
-
Molecular mimicry in innate immunity: Crystal structure of a bacterial TIR domain
-
19535337 10.1074/jbc.C109.007591 1:CAS:528:DC%2BD1MXpt1Wisro%3D
-
Chan SL, Low LY, Hsu S, Li S, Liu T, Santelli E, Le Negrate G, Reed JC, Woods VL, Pascual J (2009) Molecular mimicry in innate immunity: crystal structure of a bacterial TIR domain. J Biol Chem 284:21386-21392
-
(2009)
J Biol Chem
, vol.284
, pp. 21386-21392
-
-
Chan, S.L.1
Low, L.Y.2
Hsu, S.3
Li, S.4
Liu, T.5
Santelli, E.6
Le Negrate, G.7
Reed, J.C.8
Woods, V.L.9
Pascual, J.10
-
43
-
-
77953622695
-
Biochemical and functional analysis of TIR domain containing protein from Brucella melitensis
-
20471373 10.1016/j.bbrc.2010.05.056 1:CAS:528:DC%2BC3cXnvVOksr0%3D
-
Radhakrishnan GK, Splitter GA (2010) Biochemical and functional analysis of TIR domain containing protein from Brucella melitensis. Biochem Biophys Res Comm 397:59-63
-
(2010)
Biochem Biophys Res Comm
, vol.397
, pp. 59-63
-
-
Radhakrishnan, G.K.1
Splitter, G.A.2
-
44
-
-
16744364738
-
Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88
-
12888566 10.1074/jbc.M301742200 1:CAS:528:DC%2BD3sXotFWnsro%3D
-
Dunne A, Ejdeback M, Ludidi PL, O'Neill LAJ, Gay NJ (2003) Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88. J Biol Chem 278:41443-41451
-
(2003)
J Biol Chem
, vol.278
, pp. 41443-41451
-
-
Dunne, A.1
Ejdeback, M.2
Ludidi, P.L.3
O'Neill, L.A.J.4
Gay, N.J.5
-
45
-
-
79959331792
-
Yersinia pestis TIR-domain protein forms dimers that interact with the human adaptor protein MyD88
-
21640812 10.1016/j.micpath.2011.05.004 1:CAS:528:DC%2BC3MXot1antLg%3D
-
Rana RR, Simpson P, Zhang M, Jennions M, Ukegbu C, Spear AM, Alguel Y, Matthews SJ, Atkins HS, Byrne B (2011) Yersinia pestis TIR-domain protein forms dimers that interact with the human adaptor protein MyD88. Microb Pathog 51:89-95
-
(2011)
Microb Pathog
, vol.51
, pp. 89-95
-
-
Rana, R.R.1
Simpson, P.2
Zhang, M.3
Jennions, M.4
Ukegbu, C.5
Spear, A.M.6
Alguel, Y.7
Matthews, S.J.8
Atkins, H.S.9
Byrne, B.10
-
46
-
-
80052767894
-
Modulation of microtubule dynamics by a TIR domain protein from the intracellular pathogen, Brucella melitensis
-
21692747 10.1042/BJ20110577 1:CAS:528:DC%2BC3MXhtFKitb7K
-
Radhakrishnan G, Harms J, Splitter G (2011) Modulation of microtubule dynamics by a TIR domain protein from the intracellular pathogen, Brucella melitensis. Biochem J 439:79-83
-
(2011)
Biochem J
, vol.439
, pp. 79-83
-
-
Radhakrishnan, G.1
Harms, J.2
Splitter, G.3
-
47
-
-
79955776183
-
A Yersinia effector with enhanced inhibitory activity on the NF-κB pathway activates the NLRP3/ASC/caspase-1 inflammasome in macrophages
-
21533069 10.1371/journal.ppat.1002026 1:CAS:528:DC%2BC3MXlsVagtLY%3D
-
Zheng Y, Lilo S, Brodsky IE, Zhang Y, Medzhitov R, Marcu KB, Bliska JB (2011) A Yersinia effector with enhanced inhibitory activity on the NF-κB pathway activates the NLRP3/ASC/caspase-1 inflammasome in macrophages. PLoS Pathog 7:e1002026
-
(2011)
PLoS Pathog
, vol.7
, pp. 1002026
-
-
Zheng, Y.1
Lilo, S.2
Brodsky, I.E.3
Zhang, Y.4
Medzhitov, R.5
Marcu, K.B.6
Bliska, J.B.7
-
48
-
-
3142654210
-
Inferences, questions and possibilities in Toll-like receptor signalling
-
15241424 10.1038/nature02761 1:CAS:528:DC%2BD2cXlsVGjt7g%3D
-
Beutler B (2004) Inferences, questions and possibilities in Toll-like receptor signalling. Nature 430:257-263
-
(2004)
Nature
, vol.430
, pp. 257-263
-
-
Beutler, B.1
-
49
-
-
79551686422
-
Oncogenically active MYD88 mutations in human lymphoma
-
21179087 10.1038/nature09671 1:CAS:528:DC%2BC3MXhtVCksQ%3D%3D
-
Ngo VN, Young RM, Schmitz R, Jhavar S, Xiao W, Lim K-H, Kohlhammer H, Xu W, Yang Y, Zhao H et al (2011) Oncogenically active MYD88 mutations in human lymphoma. Nature 470:115-119
-
(2011)
Nature
, vol.470
, pp. 115-119
-
-
Ngo, V.N.1
Young, R.M.2
Schmitz, R.3
Jhavar, S.4
Xiao, W.5
Lim, K.-H.6
Kohlhammer, H.7
Xu, W.8
Yang, Y.9
Zhao, H.10
-
50
-
-
77958127248
-
Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related adaptor molecule
-
20802145 10.4049/jimmunol.1002013 1:CAS:528:DC%2BC3cXhtFyisrbF
-
Lysakova-Devine T, Keogh B, Harrington B, Nagpal K, Halle A, Golenbock DT, Monie T, Bowie AG (2010) Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related adaptor molecule. J Immunol 185:4261-4271
-
(2010)
J Immunol
, vol.185
, pp. 4261-4271
-
-
Lysakova-Devine, T.1
Keogh, B.2
Harrington, B.3
Nagpal, K.4
Halle, A.5
Golenbock, D.T.6
Monie, T.7
Bowie, A.G.8
-
51
-
-
33847369756
-
Cutting edge: Differential inhibition of TLR signaling pathways by cell-permeable peptides representing BB loops of TLRs
-
17312106 1:CAS:528:DC%2BD2sXhvFSju7k%3D
-
Toshchakov VY, Fenton MJ, Vogel SN (2007) Cutting edge: differential inhibition of TLR signaling pathways by cell-permeable peptides representing BB loops of TLRs. J Immunol 178:2655-2660
-
(2007)
J Immunol
, vol.178
, pp. 2655-2660
-
-
Toshchakov, V.Y.1
Fenton, M.J.2
Vogel, S.N.3
-
52
-
-
75149175757
-
The crystal structure of a TIR domain from Arabidopsis thaliana reveals a conserved helical region unique to plants
-
19845004 1:CAS:528:DC%2BC3cXkvFGgsA%3D%3D
-
Chan SL, Mukasa T, Santelli E, Low LY, Pascual J (2010) The crystal structure of a TIR domain from Arabidopsis thaliana reveals a conserved helical region unique to plants. Protein Sci 19:155-161
-
(2010)
Protein Sci
, vol.19
, pp. 155-161
-
-
Chan, S.L.1
Mukasa, T.2
Santelli, E.3
Low, L.Y.4
Pascual, J.5
-
53
-
-
79952643473
-
Structural and functional analysis of a plant resistance protein TIR domain reveals interfaces for self-association, signaling, and autoregulation
-
21402359 10.1016/j.chom.2011.02.009 1:CAS:528:DC%2BC3MXjtFOmsr8%3D
-
Bernoux M, Ve T, Williams S, Warren C, Hatters D, Valkov E, Zhang X et al (2011) Structural and functional analysis of a plant resistance protein TIR domain reveals interfaces for self-association, signaling, and autoregulation. Cell Host Microbe 9:200-211
-
(2011)
Cell Host Microbe
, vol.9
, pp. 200-211
-
-
Bernoux, M.1
Ve, T.2
Williams, S.3
Warren, C.4
Hatters, D.5
Valkov, E.6
Zhang, X.7
|