Staphylococcal superantigen-like protein 3 binds to the toll-like receptor 2 extracellular domain and inhibits cytokine production induced by Staphylococcus aureus, cell wall component, or lipopeptides in murine macrophages

Infection and Immunity

Volumn 80, Issue 8, 2012, Pages 2816-2825

  Yokoyama, Ryosuke ^a   Itoh, Saotomo ^a,b   Kamoshida, Go ^b   Takii, Takemasa ^a   Fujii, Satoshi ^a   Tsuji, Tsutomu ^b   Onozaki, Kikuo ^a  

^a NAGOYA CITY UNIVERSITY   (Japan)

^b HOSHI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; BACTERIAL ANTIGEN SSL3; INTERLEUKIN 12; LIPOPEPTIDE; PEPTIDOGLYCAN; SEPHAROSE; SIALIC ACID; TOLL LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN BINDING; ARTICLE; BACTERIAL CELL WALL; CHIMERA; CONTROLLED STUDY; CYTOKINE PRODUCTION; EXTRACELLULAR SPACE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MACROPHAGE; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN INTERACTION; STAPHYLOCOCCUS AUREUS;

ANIMALS; BACTERIAL PROTEINS; CELL WALL; CYTOKINES; GENE EXPRESSION REGULATION; LIPOPEPTIDES; MACROPHAGES; MICE; PEPTIDOGLYCAN; PROTEIN STRUCTURE, TERTIARY; STAPHYLOCOCCUS AUREUS; SUPERANTIGENS; TOLL-LIKE RECEPTOR 2;

EID: 84864797093     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00399-12     Document Type: Article

References (34)

1. Akira S, Takeda K. 2004. Toll-like receptor signalling. Nat. Rev. Immunol. 4:499-511.
2. Baker HM, et al. 2007. Crystal structures of the staphylococcal toxin SSL5 in complex with sialyl Lewis X reveal a conserved binding site that shares common features with viral and bacterial sialic acid binding proteins. J. Mol. Biol. 374:1298-1308.
3. Bestebroer J, et al. 2010. Functional basis for complement evasion by staphylococcal superantigen-like 7. Cell. Microbiol. 12:1506-1516.
4. Bestebroer J, et al. 2007. Staphylococcal superantigen-like 5 binds PSGL-1 and inhibits P-selectin-mediated neutrophil rolling. Blood 109: 2936-2943.
5. Bestebroer J, et al. 2009. Staphylococcal SSL5 inhibits leukocyte activation by chemokines and anaphylatoxins. Blood 113:328-337.
6. Bowie A, O'Neill LA. 2000. The interleukin-1 receptor/Toll-like receptor superfamily: signal generators for pro-inflammatory interleukins and microbial products. J. Leukoc. Biol. 67:508-514.
7. Chang YC, et al. 2009. Identification and characterization of oligonucleotides that inhibit Toll-like receptor 2-associated immune responses. FASEB J. 23:3078-3088.
8. Chung MC, et al. 2007. The crystal structure of staphylococcal superantigen-like protein 11 in complex with sialyl Lewis X reveals the mechanism for cell binding and immune inhibition. Mol. Microbiol. 66:1342-1355.
9. Cirl C, et al. 2008. Subversion of Toll-like receptor signaling by a unique family of bacterial Toll/interleukin-1 receptor domain-containing proteins. Nat. Med. 14:399-406.
10. Easmon CS, Glynn AA. 1976. Comparison of subcutaneous and intraperitoneal staphylococcal infections in normal and complement-deficient mice. Infect. Immun. 13:399-406.
11. Fournier B, Philpott DJ. 2005. Recognition of Staphylococcus aureus by the innate immune system. Clin. Microbiol. Rev. 18:521-540.
12. Gonzalez-Zorn B, et al. 2005. Bacterial and host factors implicated in nasal carriage of methicillin-resistant Staphylococcus aureus in mice. Infect. Immun. 73:1847-1851.
13. Heyworth PG, Cross AR, Curnutte JT. 2003. Chronic granulomatous disease. Curr. Opin. Immunol. 15:578-584.
14. Hoebe K, et al. 2005. CD36 is a sensor of diacylglycerides. Nature 433: 523-527.
15. Itoh S, et al. 2010. Staphylococcal superantigen-like protein 5 inhibits matrix metalloproteinase 9 from human neutrophils. Infect. Immun. 78: 3298-3305.
16. Itoh S, et al. 2010. Staphylococcal superantigen-like protein 10 (SSL10) binds to human immunoglobulin G (IgG) and inhibits complement activation via the classical pathway. Mol. Immunol. 47:932-938.
17. Jann NJ, Schmaler M, Ferracin F, Landmann R. 2011. TLR2 enhances NADPH oxidase activity and killing of Staphylococcus aureus by PMN. Immunol. Lett. 135:17-23.
18. Janssens S, Beyaert R. 2003. Role of Toll-like receptors in pathogen recognition. Clin. Microbiol. Rev. 16:637-646.
19. Laemmli U. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
20. Langley R, Patel D, Jackson N, Clow F, Fraser JD. 2010. Staphylococcal superantigen super-domains in immune evasion. Crit. Rev. Immunol. 30:149-165.
21. Langley R, et al. 2005. The staphylococcal superantigen-like protein 7 binds IgA and complement C5 and inhibits IgA-Fcα RI binding and serum killing of bacteria. J. Immunol. 174:2926-2933.
22. Marodi L, Kalmar A, Szabo I. 1989. Opsonic activity in serum from septic infants treated with intravenous immunoglobulin. Arch. Dis. Child. 64: 530-534.
23. Patel D, Wines BD, Langley RJ, Fraser JD. 2010. Specificity of staphylococcal superantigen-like protein 10 toward the human IgG1 Fc domain. J. Immunol. 184:6283-6292.
24. Raby AC, et al. 2009. Soluble TLR2 reduces inflammation without compromising bacterial clearance by disrupting TLR2 triggering. J. Immunol. 183:506-517.
25. Ruff MR, Gifford GE. 1980. Purification and physico-chemical characterization of rabbit tumor necrosis factor. J. Immunol. 125:1671-1677.
26. Sandor F, et al. 2003. Importance of extra- and intracellular domains of TLR1 and TLR2 in NFk{cyrillic}B signaling. J. Cell Biol. 162:1099-1110.
27. Shin JE, Kim YS, Oh JE, Min BM, Choi Y. 2010. Treponema denticola suppresses expression of human β-defensin-3 in gingival epithelial cells through inhibition of the toll-like receptor 2 axis. Infect. Immun. 78:672-679.
28. Strunk T, et al. 2010. TLR2 mediates recognition of live Staphylococcus epidermidis and clearance of bacteremia. PLoS One 5:e10111. doi: 10.1371/journal.pone.0010111.
29. Takeda K, Akira S. 2004. TLR signaling pathways. Semin. Immunol. 16:3-9.
30. Takeuchi O, Hoshino K, Akira S. 2000. Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection. J. Immunol. 165:5392-5396.
31. Takeuchi O, et al. 2001. Discrimination of bacterial lipoproteins by Tolllike receptor 6. Int. Immunol. 13:933-940.
32. Walenkamp AM, et al. 2009. Staphylococcal superantigen-like 10 inhibits CXCL12-induced human tumor cell migration. Neoplasia 11:333-344.
33. Williams RJ, et al. 2000. Identification of a novel gene cluster encoding staphylococcal exotoxin-like proteins: characterization of the prototypic gene and its protein product, SET1. Infect. Immun. 68:4407-4415.
34. Zahringer U, Lindner B, Inamura S, Heine H, Alexander C. 2008. TLR2: promiscuous or specific? A critical re-evaluation of a receptor expressing apparent broad specificity. Immunobiology 213:205-224.