Somatic mutation and gain of copy number of PIK3CA in human breast cancer

Breast Cancer Research

Volumn 7, Issue 5, 2005, Pages

  Wu, Guojun ^a   Xing, Mingzhao ^a   Mambo, Elizabeth ^a   Huang, Xin ^b   Liu, Junwei ^a   Guo, Zhongmin ^a   Chatterjee, Aditi ^a   Goldenberg, David ^a   Gollin, Susanne M ^b   Sukumar, Saraswati ^c   Trink, Barry ^a   Sidransky, David ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ACTIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; 2 MORPHOLINO 8 PHENYLCHROMONE; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; CHROMONE DERIVATIVE; ENZYME INHIBITOR; MORPHOLINE DERIVATIVE; PIK3CA PROTEIN, HUMAN; TUMOR MARKER;

AMINO ACID SUBSTITUTION; APOPTOSIS; ARTICLE; BREAST CANCER; BREAST CANCER CELL LINE; CANCER GROWTH; CELL ADHESION; CELL MOTILITY; CELL PROLIFERATION; CELL SURVIVAL; ENZYME INHIBITION; EXON; FLUORESCENCE IN SITU HYBRIDIZATION; GAIN OF FUNCTION MUTATION; GENE AMPLIFICATION; GENE DELETION; GENE DOSAGE; HUMAN; PIK3CA GENE; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SOMATIC MUTATION; TUMOR GENE; WESTERN BLOTTING; BREAST TUMOR; CANCER STAGING; CELL DIVISION; CHROMOSOME MAP; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; GENETICS; METABOLISM; MUTATION; NEOPLASM; PATHOLOGY; POLYMERASE CHAIN REACTION; TUMOR CELL LINE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; APOPTOSIS; BREAST NEOPLASMS; CELL DIVISION; CELL LINE, TUMOR; CELL SURVIVAL; CHROMONES; CHROMOSOME MAPPING; ENZYME INHIBITORS; FEMALE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MORPHOLINES; MUTATION; NEOPLASM STAGING; NEOPLASMS; POLYMERASE CHAIN REACTION; TUMOR MARKERS, BIOLOGICAL;

EID: 27544515272     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr1262     Document Type: Article

References (20)

1. Leevers SJ, Vanhaesebroeck B, Waterfield MD: Signalling through phosphoinositide 3-kinases: the lipids take centre stage. Curr Opin Cell Biol. 1999, 11: 219-225 10.1016/S0955-0674(99)80029-5.
2. Vivanco I, Sawyers CL: The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer. 2002, 2: 489-501 10.1038/nrc839.
3. Knuutila S, Bjorkqvist AM, Autio K, Tarkkanen M, Wolf M, Monni O, Szymanska J, Larramendy ML, Tapper J, Pere H, et al: DNA copy number amplifications in human neoplasms: review of comparative genomic hybridization studies. Am J Pathol. 1998, 152: 1107-1123.
4. Rooney PH, Murray GI, Stevenson DA, Haites NE, Cassidy J, McLeod HL: Comparative genomic hybridization and chromosomal instability in solid tumours. Br J Cancer. 1999, 80: 862-873 10.1038/sj.bjc.6690433.
5. Larramendy ML, Lushnikova T, Bjorkqvist AM, Wistuba II, Virmani AK, Shivapurkar N, Gazdar AF, Knuutila S: Comparative genomic hybridization reveals complex genetic changes in primary breast cancer tumors and their cell lines. Cancer Genet Cytogenet. 2000, 119: 132-138 10.1016/S0165-4608(99)00226-5.
6. Ma YY, Wei SJ, Lin YC, Lung JC, Chang TC, Whang-Peng J, Liu JM, Yang DM, Yang WK, Shen CY: PIK3CA as an oncogene in cervical cancer. Oncogene. 2000, 19: 2739-2744 10.1038/sj.onc.1203597.
7. Racz A, Brass N, Heckel D, Pahl S, Remberger K, Meese E: Expression analysis of genes at 3q26-q27 involved in frequent amplification in squamous cell lung carcinoma. Eur J Cancer. 1999, 35: 641-646 10.1016/S0959-8049(98)00419-5.
8. Redon R, Muller D, Caulee K, Wanherdrick K, Abecassis J, du Manoir S: A simple specific pattern of chromosomal aberrations at early stages of head and neck squamous cell carcinomas: PIK3CA but not p63 gene as a likely target of 3q26-qter gains. Cancer Res. 2001, 61: 4122-4129.
9. Shayesteh L, Lu Y, Kuo WL, Baldocchi R, Godfrey T, Collins C, Pinkel D, Powell B, Mills GB, Gray JW: PIK3CA is implicated as an oncogene in ovarian cancer. Nat Genet. 1999, 21: 99-102 10.1038/5042.
10. Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S, Yan H, Gazdar A, Powell SM, Riggins GJ, et al: High frequency of mutations of the PIK3CA gene in human cancers. Science. 2004, 304: 554. 10.1126/science.1096502.
11. Mambo E, Gao X, Cohen Y, Guo Z, Talalay P, Sidransky D: Electrophile and oxidant damage of mitochondrial DNA leading to rapid evolution of homoplasmic mutations. Proc Natl Acad Sci USA. 2003, 100: 1838-1843 10.1073/pnas.0437910100.
12. Ried T, Lengauer C, Cremer T, Wiegant J, Raap AK, van der Ploeg M, Groitl P, Lipp M: Specific metaphase and interphase detection of the breakpoint region in 8q24 of Burkitt lymphoma cells by triple-color fluorescence in situ hybridization. Genes Chromosomes Cancer. 1992, 4: 69-74.
13. Kang S, Bader AG, Vogt PK: Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic. Proc Natl Acad Sci USA. 2005, 102: 802-807 10.1073/pnas.0408864102.
14. Yakes FM, Van Houten B: Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc Natl Acad Sci USA. 1997, 94: 514-519 10.1073/pnas.94.2.514.
15. Ayala-Torres S, Chen Y, Svoboda T, Rosenblatt J, Van Houten B: Analysis of gene-specific DNA damage and repair using quantitative polymerase chain reaction. Methods. 2000, 22: 135-147 10.1006/meth.2000.1054.
16. Ingvarsson S: Molecular genetics of breast cancer progression. Semin Cancer Biol. 1999, 9: 277-288 10.1006/scbi.1999.0124.
17. Nathanson KL, Wooster R, Weber BL: Breast cancer genetics: what we know and what we need. Nat Med. 2001, 7: 552-556 10.1038/87876.
18. Lengauer C, Kinzler KW, Vogelstein B: Genetic instabilities in human cancers. Nature. 1998, 396: 643-649 10.1038/25292.
19. Gray JW, Collins C: Genome changes and gene expression in human solid tumors. Carcinogenesis. 2000, 21: 443-452 10.1093/carcin/21.3.443.
20. Bachman KE, Argani P, Samuels Y, Silliman N, Ptak J, Szabo S, Konishi H, Karakas B, Blair BG, Lin C, et al: The PIK3CA gene is mutated with high frequency in human breast cancers. Cancer Biol Ther. 2004, 3: 772-775.