Geldanamycin attenuates 3-nitropropionic acid-induced apoptosis and JNK activation through the expression of HSP 70 in striatal cells

International Journal of Molecular Medicine

Volumn 34, Issue 1, 2014, Pages 24-34

  Choi, Yong Joon ^a   Kim, Nam Ho ^a   Lim, Man Sup ^a   Lee, Hee Jae ^a   Kim, Sung Soo ^a   Chun, Wanjoo ^a  

^a Kangwon National University   (South Korea)

Author keywords

3 nitropropionic acid; Geldanamycin; Heat shock protein 70; Huntington's disease; Reactive oxygen species

Indexed keywords

3 NITROPROPIONIC ACID; GELDANAMYCIN; HEAT SHOCK PROTEIN 70; I KAPPA B ALPHA; LACTATE DEHYDROGENASE; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; TRIPTOLIDE; 3-NITROPROPIONIC ACID; BENZOQUINONE DERIVATIVE; DITERPENE; EPOXIDE; MACROCYCLIC LACTAM; NITRO DERIVATIVE; PHENANTHRENE DERIVATIVE; PROPIONIC ACID DERIVATIVE;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BRAIN CELL; CELL VIABILITY; CONTROLLED STUDY; CORPUS STRIATUM; CYTOTOXICITY; DNA FRAGMENTATION; DRUG MECHANISM; ENZYME ACTIVATION; NEUROPROTECTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; AGONISTS; ANTAGONISTS AND INHIBITORS; CELL LINE; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; NERVE CELL; PHOSPHORYLATION;

APOPTOSIS; BENZOQUINONES; CELL LINE; CORPUS STRIATUM; DITERPENES; EPOXY COMPOUNDS; GENE EXPRESSION REGULATION; HSP70 HEAT-SHOCK PROTEINS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LACTAMS, MACROCYCLIC; NEURONS; NITRO COMPOUNDS; PHENANTHRENES; PHOSPHORYLATION; PROPIONATES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84902675831     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2014.1747     Document Type: Article

References (56)

1. Andrew SE, Goldberg YP, Kremer B, et al: The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease. Nat Genet 4: 398-403, 1993. (Pubitemid 23231490)
2. Vonsattel JP and DiFiglia M: Huntington disease. J Neuropathol Exp Neurol 57: 369-384, 1998. (Pubitemid 28237321)
3. Beal MF: Mitochondria take center stage in aging and neurodegeneration. Ann Neurol 58: 495-505, 2005.
4. Oliveira JM, Jekabsons MB, Chen S, et al: Mitochondrial dysfunction in Huntington's disease: the bioenergetics of isolated and in situ mitochondria from transgenic mice. J Neurochem 101: 241-249, 2007. (Pubitemid 46426480)
5. Garcia M, Vanhoutte P, Pages C, Besson MJ, Brouillet E and Caboche J: The mitochondrial toxin 3-nitropropionic acid induces striatal neurodegeneration via a c -Jun N -terminal kinase/c-Jun module. J Neurosci 22: 2174-2184, 2002. (Pubitemid 35386517)
6. Brouillet E, Condé F, Beal MF and Hantraye P: Replicating Huntington's disease phenotype in experimental animals. Prog Neurobiol 59: 427-468, 1999. (Pubitemid 29392967)
7. Choi YJ, Om JY, Kim NH, et al: Heat shock transcription factor-1 suppresses apoptotic cell death and ROS generation in 3-nitropropionic acid-stimulated striatal cells. Mol Cell Biochem 375: 59-67, 2013.
8. Dedeoglu A, Ferrante RJ, Andreassen OA, Dillmann WH and Beal MF: Mice overexpressing 70-kDa heat shock protein show increased resistance to malonate and 3-nitropropionic acid. Exp Neurol 176: 262-265, 2002. (Pubitemid 34762127)
9. Takayama S, Reed JC and Homma S: Heat-shock proteins as regulators of apoptosis. Oncogene 22: 9041-9047, 2003. (Pubitemid 38121704)
10. Beere HM, Wolf BB, Cain K, et al: Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome. Nat Cell Biol 2: 469-475, 2000.
11. Cummings CJ, Mancini MA, Antalffy B, DeFranco DB, Orr HT and Zoghbi HY: Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1. Nat Genet 19: 148-154, 1998. (Pubitemid 28248795)
12. Kobayashi Y, Kume A, Li M, et al: Chaperones Hsp70 and Hsp40 suppress aggregate formation and apoptosis in cultured neuronal cells expressing truncated androgen receptor protein with expanded polyglutamine tract. J Biol Chem 275: 8772-8778, 2000. (Pubitemid 30180231)
13. Wyttenbach A, Swartz J, Kita H, et al: Polyglutamine expansions cause decreased CRE-mediated transcription and early gene expression changes prior to cell death in an inducible cell model of Huntington's disease. Hum Mol Genet 10: 1829-1845, 2001. (Pubitemid 32899099)
14. Mosser DD, Caron AW, Bourget L, Denis-Larose C and Massie B: Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis. Mol Cell Biol 17: 5317-5327, 1997. (Pubitemid 27357630)
15. Jäättelä M, Wissing D, Kokholm K, Kallunki T and Egeblad M: Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases. EMBO J 17: 6124-6134, 1998. (Pubitemid 28497786)
16. Mosser DD, Caron AW, Bourget L, et al: The chaperone function of hsp70 is required for protection against stress-induced apoptosis. Mol Cell Biol 20: 7146-7159, 2000.
17. Ravagnan L, Gurbuxani S, Susin SA, et al: Heat-shock protein 70 antagonizes apoptosis-inducing factor. Nat Cell Biol 3: 839-843, 2001. (Pubitemid 32842690)
18. Gurbuxani S, Schmitt E, Cande C, et al: Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor. Oncogene 22: 6669-6678, 2003. (Pubitemid 37372207)
19. Koga F, Xu W, Karpova TS, McNally JG, Baron R and Neckers L: Hsp90 inhibition transiently activates Src kinase and promotes Src-dependent Akt and Erk activation. Proc Natl Acad Sci USA 103: 11318-11322, 2006. (Pubitemid 44156515)
20. Schulte TW, Akinaga S, Soga S, et al: Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin. Cell Stress Chaperones 3: 100-108, 1998. (Pubitemid 28327422)
21. Zou J, Guo Y, Guettouche T, Smith DF and Voellmy R: Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1. Cell 94: 471-480, 1998. (Pubitemid 28391863)
22. Bagatell R, Paine-Murrieta GD, Taylor CW, et al: Induction of a heat shock factor 1-dependent stress response alters the cytotoxic activity of hsp90-binding agents. Clin Cancer Res 6: 3312-3318, 2000. (Pubitemid 30637762)
23. Sittler A, Lurz R, Lueder G, et al: Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease. Hum Mol Genet 10: 1307-1315, 2001. (Pubitemid 32600484)
24. Bian X, McAllister-Lucas LM, Shao F, et al: NF-kappa B activation mediates doxorubicin-induced cell death in N-type neuroblastoma cells. J Biol Chem 276: 48921-48929, 2001.
25. Bubici C, Papa S, Pham CG, Zazzeroni F and Franzoso G: The NF-kappaB-mediated control of ROS and JNK signaling. Histol Histopathol 21: 69-80, 2006. (Pubitemid 43033716)
26. Dumont A, Hehner SP, Hofmann TG, Ueffing M, Dröge W and Schmitz ML: Hydrogen peroxide-induced apoptosis is CD95-independent, requires the release of mitochondria-derived reactive oxygen species and the activation of NF-kappaB. Oncogene 18: 747-757, 1999. (Pubitemid 29080332)
27. Westerheide SD, Kawahara TL, Orton K and Morimoto RI: Triptolide, an inhibitor of the human heat shock response that enhances stress-induced cell death. J Biol Chem 281: 9616-9622, 2006. (Pubitemid 43864680)
28. Wyttenbach A: Role of heat shock proteins during polyglutamine neurodegeneration: mechanisms and hypothesis. J Mol Neurosci 23: 69-96, 2004.
29. Muchowski PJ and Wacker JL: Modulation of neurodegeneration by molecular chaperones. Nat Rev Neurosci 6: 11-22, 2005. (Pubitemid 40052135)
30. Ciocca DR, Clark GM, Tandon AK, Fuqua SA, Welch WJ and McGuire WL: Heat shock protein hsp70 in patients with axillary lymph node-negative breast cancer: prognostic implications. J Natl Cancer Inst 85: 570-574, 1993. (Pubitemid 23110932)
31. Dive C and Hickman JA: Drug-target interactions: only the first step in the commitment to a programmed cell death? Br J Cancer 64: 192-196, 1991.
32. Seo JS, Park YM, Kim JI, et al: T cell lymphoma in transgenic mice expressing the human Hsp70 gene. Biochem Biophys Res Commun 218: 582-587, 1996.
33. Wei YQ, Zhao X, Kariya Y, Teshigawara K and Uchida A: Inhibition of proliferation and induction of apoptosis by abrogation of heat-shock protein (HSP) 70 expression in tumor cells. Cancer Immunol Immunother 40: 73-78, 1995.
34. Haldimann P, Muriset M, Vigh L and Goloubinoff P: The novel hydroxylamine derivative NG-094 suppresses polyglutamine protein toxicity in Caenorhabditis elegans. J Biol Chem 286: 18784-18794.
35. Neckers L: Hsp90 inhibitors as novel cancer chemotherapeutic agents. Trends Mol Med 8: S55-S61, 2002.
36. Panaretou B, Prodromou C, Roe SM, et al: ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo. EMBO J 17: 4829-4836, 1998. (Pubitemid 28377183)
37. Grenert JP, Johnson BD and Toft DO: The importance of ATP binding and hydrolysis by hsp90 in formation and function of protein heterocomplexes. J Biol Chem 274: 17525-17533, 1999.
38. Schneider C, Sepp-Lorenzino L, Nimmesgern E, et al : Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90. Proc Natl Acad Sci USA 93: 14536-14541, 1996. (Pubitemid 26419002)
39. Connell P, Ballinger CA, Jiang J, et al: The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins. Nat Cell Biol 3: 93-96, 2001. (Pubitemid 32114838)
40. Xu W, Marcu M, Yuan X, Mimnaugh E, Patterson C and Neckers L: Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu. Proc Natl Acad Sci USA 99: 12847-12852, 2002.
41. Wacker JL, Huang SY, Steele AD, et al: Loss of Hsp70 exacerbates pathogenesis but not levels of fibrillar aggregates in a mouse model of Huntington's disease. J Neurosci 29: 9104-9114, 2009.
42. Shen HY, He JC, Wang Y, Huang QY and Chen JF: Geldanamycin induces heat shock protein 70 and protects against MPTP-induced dopaminergic neurotoxicity in mice. J Biol Chem 280: 39962-39969, 2005. (Pubitemid 41779131)
43. Beal MF: Energetics in the pathogenesis of neurodegenerative diseases. Trends Neurosci 23: 298-304, 2000.
44. Gu M, Gash MT, Mann VM, Javoy-Agid F, Cooper JM and Schapira AH: Mitochondrial defect in Huntington's disease caudate nucleus. Ann Neurol 39: 385-389, 1996. (Pubitemid 26100764)
45. Browne SE, Bowling AC, MacGarvey U, et al: Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia. Ann Neurol 41: 646-653, 1997. (Pubitemid 27212659)
46. Sawa A, Wiegand GW, Cooper J, et al: Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization. Nat Med 5: 1194-1198, 1999. (Pubitemid 29474426)
47. Beal MF, Brouillet E, Jenkins BG, et al: Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid. J Neurosci 13: 4181-4192, 1993. (Pubitemid 23299942)
48. Hamilton BF and Gould DH: Nature and distribution of brain lesions in rats intoxicated with 3-nitropropionic acid: a type of hypoxic (energy deficient) brain damage. Acta Neuropathol 72: 286-297, 1987. (Pubitemid 17006851)
49. Brouillet E, Hantraye P, Ferrante RJ, et al: Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates. Proc Natl Acad Sci USA 92: 7105-7109, 1995.
50. Palfi S, Ferrante RJ, Brouillet E, et al: Chronic 3-nitropropionic acid treatment in baboons replicates the cognitive and motor deficits of Huntington's disease. J Neurosci 16: 3019-3025, 1996. (Pubitemid 26121844)
51. Gabai VL, Meriin AB, Yaglom JA, Volloch VZ and Sherman MY: Role of Hsp70 in regulation of stress-kinase JNK: implications in apoptosis and aging. FEBS Lett 438: 1-4, 1998. (Pubitemid 28517824)
52. Meriin AB, Yaglom JA, Gabai VL, et al: Protein-damaging stresses activate c-Jun N-terminal kinase via inhibition of its dephosphorylation: a novel pathway controlled by HSP72. Mol Cell Biol 19: 2547-2555, 1999. (Pubitemid 29144498)
53. Kyriakis JM and Avruch J: Protein kinase cascades activated by stress and inflammatory cytokines. Bioessays 18: 567-577, 1996. (Pubitemid 26311096)
54. Park HS, Lee JS, Huh SH, Seo JS and Choi EJ: Hsp72 functions as a natural inhibitory protein of c-Jun N-terminal kinase. EMBO J 20: 446-456, 2001.
55. Lee JS, Lee JJ and Seo JS: HSP70 deficiency results in activation of c-Jun N-terminal Kinase, extracellular signal-regulated kinase, and caspase-3 in hyperosmolarity-induced apoptosis. J Biol Chem 280: 6634-6641, 2005.
56. Li H, Liu L, Xing D and Chen WR: Inhibition of the JNK/Bim pathway by Hsp70 prevents Bax activation in UV?induced apoptosis. FEBS Lett 584: 4672-4678, 2010.