Design, synthesis and antifungal activity of novel triazole derivatives containing substituted 1,2,3-triazole-piperdine side chains

European Journal of Medicinal Chemistry

Volumn 82, Issue , 2014, Pages 490-497

  Jiang, Zhigan ^a,b   Gu, Julin ^c   Wang, Chen ^d   Wang, Shengzheng ^a   Liu, Na ^a   Jiang, Yan ^a   Dong, Guoqiang ^a   Wang, Yan ^a   Liu, Yang ^a   Yao, Jianzhong ^a   Miao, Zhenyuan ^a   Zhang, Wannian ^a   Sheng, Chunquan ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b WUXI APPTEC   (China)

^c SECOND MILITARY MEDICAL UNIVERSITY   (China)

^d SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Antifungal activities; Click reaction; Triazole derivatives

Indexed keywords

1 (1 (2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 3 (1H 1,2,4 TRIAZOL 1 YL)PROPYL) PIPERIDIN 4 YL) 1H 1,2,3 TRIAZOLE 4 CARBOXYLIC ACID; 1 (4 (1 (1 (2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 3 (1H 1,2,4 TRIAZOL 1 YL) PROPYL)PIPERIDIN 4 YL) 1H 1,2,3 TRIAZOL 4 YL)PHENYL)ETHANONE; 1 (4 (4 (4 BROMOPHENYL) 1H 1,2,3 TRIAZOL 1 YL)PIPERIDIN 1 YL) 2 (2,4 DIFLUOROPHENYL) 3 (1H 1,2,4 TRIAZOLE 1 YL)PROPAN 2 OL; 1 (4 (4 BENZYL 1H 1,2,3 TRIAZOL 1 YL)PIPERIDIN 1 YL) 2 (2,4 DIFLUOROPHENYL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 1 (4 (4 CYCLOPENTYL 1H 1,2,3 TRIAZOL 1 YL)PIPERIDIN 1 YL) 2 (2,4 DIFLUOROPHENYL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 1 (4 (4 CYCLOPROPYL 1H 1,2,3 TRIAZOL 1 YL)PIPERIDIN 1 YL) 2 (2,4 DIFLUOROPHENYL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 1 (1H 1,2,4 TRIAZOL 1 YL) 3 (4 (4 (4 (TRIFLUOROMETHOXY) PHENYL) 1H 1,2,3 TRIAZOL 1 YL) PROPAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 1 (4 (4 (1 HYDROXYETHYL) 1H 1,2,3 TRIAZOL 1 YL) PIPERIDIN 1 YL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 1 (4 (4 (2 HYDROXYETHYL) 1H 1,2,3 TRIAZOL 1 YL) PIPERIDIN 1 YL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 1 (4 (4 (3 METHOXYPHENYL) 1H 1,2,3 TRIAZOL 1 YL) PIPERIDIN 1 YL) 3 (1H 1,2,4 TRIASOL 1 YL)PROPAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 1 (4 (4 (3 METHOXYPHENYL) 1H 1,2,3 TRIAZOL 1 YL) PIPERIDIN 1 YL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 1 (4 (4 (4 (DIMETHYLAMINO) PHENYL) 1H 1,2,3 TRIAZOL 1 YL)PIPERIDIN 1 YL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 1 (4 (4 (HYDROXY(PHENYL)METHYL) 1H 1,2,3 TRIAZOL 1 YL) PIPERIDIN 1 YL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 1 (4 (4 (HYDROXYMETHYL) 1H 1,2,3 TRIAZOL 1 YL) PIPERIDIN 1 YL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 1 (4 (4 (METHOXYMETHYL) 1H 1,2,3 TRIAZOL 1 YL) PIPERIDIN 1 YL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 1 (4 (4 (O TOLYL) 1H 1,2,3 TRIAZOL 1 YL)PIPERDIN 1 YL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 1 (4 (4 (PYRIDIN 3 YL) 1H 1,2,3 TRIAZOL 1 YL) PIPERIDIN 1 YL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 1 (4 (4 ETHYL 1H 1,2,3 TRIAZOL 1 YL)PIPERIDIN 1 YL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 1 (4 (4 PHENYL 1H 1,2,3 TRIAZOL 1 YL)PIPERIDIN 1 YL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 1 (4 (4 PROPYL 1 H 1,2,3 TRIAZOL 1 YL)PIPERIDIN 1 YL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 3 (1 (1 (2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 3 (1H 1,2,4 TRIAZOL 1 YL)PROPYL) PIPERIDIN 4 YL) 1H 1,2,3 TRIAZOL 4 YL)PROPAN 1 OL; 4 (1 (1 (2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 3 (1H 1,2,4 TRIAZOL 1 YL)PROPYL) PIPERIDIN 4 YL) 1H 1,2,3 TRIAZOL 4 YL)BUTAN 1 OL; 4 (1 (1 (2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 3 (1H 1,2,4 TRIAZOL 1 YL)PROPYL) PIPERIDIN 4 YL) 1H 1,2,3 TRIAZOL 4 YL)BUTANOIC ACID; ANTIFUNGAL AGENT; ETHYL 1 (1 (2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 3 (1H 1,2,4 TRIAZOL 1 YL) PROPYL)PIPERIDIN 4 YL) 1H 1,2,3 TRIAZOLE 4 CARBOXYLATE; METHYL 4 (1 (1 (2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 3 (1H 1,2,4 TRIAZOL 1 YL) PROPYL) PIPERIDIN 4 YL) 1H 1,2,3 TRIAZOL 4 YL) BUTANOATE; STEROL 14ALPHA DEMETHYLASE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; PIPERIDINE DERIVATIVE;

ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CONTROLLED STUDY; CRYPTOCOCCUS NEOFORMANS; DRUG DESIGN; DRUG INHIBITION; DRUG SYNTHESIS; HYDROPHOBICITY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; SUBSTITUTION REACTION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; MICROBIAL SENSITIVITY TEST; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTIFUNGAL AGENTS; CANDIDA ALBICANS; CRYPTOCOCCUS NEOFORMANS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PIPERIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 84902661493     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.05.079     Document Type: Article

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