Design, synthesis, and invitro antifungal activity of 1-[(4-substituted-benzyl)methylamino]-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ols

ChemMedChem

Volumn 6, Issue 5, 2011, Pages 816-825

  Guillon, Rémi ^a   Pagniez, Fabrice ^a   Giraud, Francis ^a   Crépin, Damien ^a   Picot, Carine ^a   LeBorgne, Marc ^a   Morio, Florent ^a   Duflos, Muriel ^a   Logé, Cédric ^a   LePape, Patrice ^a  

^a UNIVERSITÉ DE NANTES   (France)

Author keywords

Antifungal agents; Candida albicans; CYP51 inhibitors; Structure activity relationships; Triazoles

Indexed keywords

1 [(4 SUBSTITUTED-BENZYL)METHYLAMINO] 2 (2,4 DIFLUOROPHENYL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; BENZYLAMINE DERIVATIVE; FLUCONAZOLE; STEROL 14ALPHA DEMETHYLASE; SULFONAMIDE; UNCLASSIFIED DRUG; 4-(((2-(2,4-DIFLUOROPHENYL)-2-HYDROXY-3-(1H-1,2,4-TRIAZOL-1-YL)PROPYL)METHYLAMIN O)METHYL)-N-(PHENYL)BENZENESULFONAMIDE; 1,2,4 TRIAZOLE; 1,2,4-TRIAZOLE; 4 (((2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 3 (1H 1,2,4 TRIAZOL 1 YL)PROPYL)METHYLAMINO)METHYL) N (PHENYL)BENZENESULFONAMIDE; ANTIFUNGAL AGENT; PROPANOL; STEROL 14ALPHA DEMETHYLASE INHIBITOR; TRIAZOLE DERIVATIVE;

ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA; FILAMENTOUS ALGA; IN VITRO STUDY; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; ASPERGILLUS FUMIGATUS; BINDING SITE; CANDIDA ALBICANS; CHEMISTRY; COMPUTER SIMULATION; DRUG DESIGN; DRUG EFFECT; ENZYME ACTIVE SITE; METABOLISM; MICROBIOLOGICAL EXAMINATION; SYNTHESIS;

14-ALPHA DEMETHYLASE INHIBITORS; ANTIFUNGAL AGENTS; ASPERGILLUS FUMIGATUS; BINDING SITES; CANDIDA ALBICANS; CATALYTIC DOMAIN; COMPUTER SIMULATION; DRUG DESIGN; MICROBIAL SENSITIVITY TESTS; PROPANOLS; STEROL 14-DEMETHYLASE; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; TRIAZOLES;

EID: 79954997194     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201000530     Document Type: Article

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