Synthesis and in vitro antifungal evaluation of 2-(2,4-difluorophenyl)-1- [(1H-indol-3-ylmethyl)methylamino]-3-(1H-1,2,4-triazol-1-yl)propan-2-ols

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 26, Issue 2, 2011, Pages 261-269

  Guillon, Rémi ^a   Logé, Cédric ^a   Pagniez, Fabrice ^a   Ferchaud Roucher, Véronique ^c   Duflos, Muriel ^a   Picot, Carine ^a   Pape, Patrice Le ^a,b  

^a UNIVERSITÉ DE NANTES   (France)

^b HÔTEL DIEU   (France)

^c IRT UN   (France)

Author keywords

antifungal agents; Azoles; Candida albicans; indoles

Indexed keywords

1 (TERT BUTOXYCARBONYL) 1H INDOLE 3 CARBALDEHYDE; 1 (TERT BUTOXYCARBONYL) 6 FLUORO 1H INDOLE 3 CARBALDEHYDE; 1 [[(1 TERT BUTOXYCARBONYL 6 FLUOROINDOL 3 YL)METHYL]METHYLAMINO] 2 (2,4 DIFLUOROPHENYL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 1 [[(1 TERT BUTOXYCARBONYLINDOL 3 YL)METHYL]METHYLAMINO] 2 (2,4 DIFLUOROPHENYL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 1 [[(5 (TERT BUTOXYCARBONYL) 1,3 DIOXOLO[4,5 F]INDOL 7 YL]METHYL]METHYLAMINO) 2 (2,4 DIFLUOROPHENYL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 1 [[(5H 1,3 DIOXOLO[4,5 F]INDOL 7 YL)METHYL]METHYLAMINO] 2 (2,4 DIFLUOROPHENYL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 1H INDOLE 3 CARBALDEHYDE; 2 (2,4 DIFLUOROPHENYL) 1 [(1H INDOL 3 YLMETHYL)METHYLAMINO] 3 (1H 1,2,4 TRIAZOL 1 YL) PROPAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 1 [(6 FLUORO 1H INDOL 3 YLMETHYL)METHYLAMINO] 3 (1H 1,2,4 TRIAZOL 1 YL) PROPAN 2 OL; 5 (TERT BUTOXYCARBONYL) 1,3 DIOXOLO[4,5 F]INDOLE 7 CARBALDEHYDE; 5H 1,3 DIOXOLO[4,5 F]INDOLE 7 CARBALDEHYDE; 6 FLUORO 1H INDOLE 3 CARBALDEHYDE; ANTIFUNGAL AGENT; INDOLE DERIVATIVE; STEROL 14ALPHA DEMETHYLASE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL;

ANTIFUNGAL AGENTS; CANDIDA ALBICANS; CATALYTIC DOMAIN; DRUG DESIGN; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PROPANOLS; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

CANDIDA ALBICANS;

EID: 79952743218     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.3109/14756366.2010.503607     Document Type: Article

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