Structure-based rational design, synthesis and antifungal activity of oxime-containing azole derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 9, 2010, Pages 2942-2945

  Xu, Yulan ^a   Sheng, Chunquan ^a   Wang, Wenya ^a   Che, Xiaoying ^a   Cao, Yongbing ^a   Dong, Guoqiang ^a   Wang, Shengzheng ^a   Ji, Haitao ^b   Miao, Zhenyuan ^a   Yao, Jianzhong ^a   Zhang, Wannian ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b Center for Drug Discovery and Chemical Biology ^*  (United States)

Author keywords

Antifungal activity; Azole; Molecular docking; Oxime; Rational design

Indexed keywords

ALBACONAZOLE; FLUCONAZOLE; ITRACONAZOLE; POSACONAZOLE; PYRROLE DERIVATIVE; RAVUCONAZOLE; VORICONAZOLE;

ANTIFUNGAL ACTIVITY; ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGEN BOND; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANTIFUNGAL AGENTS; AZOLES; BINDING SITES; CATALYTIC DOMAIN; COMPUTER SIMULATION; CYTOCHROME P-450 ENZYME SYSTEM; DRUG DESIGN; MICROBIAL SENSITIVITY TESTS; OXIMES; STRUCTURE-ACTIVITY RELATIONSHIP;

CANDIDA ALBICANS;

EID: 77950806733     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.03.014     Document Type: Article

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