Discovery of highly potent novel antifungal azoles by structure-based rational design

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 20, 2009, Pages 5965-5969

  Wang, Wenya ^a   Sheng, Chunquan ^a   Che, Xiaoying ^a   Ji, Haitao ^b   Cao, Yongbing ^a   Miao, Zhenyuan ^a   Yao, Jianzhong ^a   Zhang, Wannian ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Antifungal activity; Azole; Molecular docking; Rational design

Indexed keywords

FLUCONAZOLE; ITRACONAZOLE; PYRROLE DERIVATIVE; STEROL 14ALPHA DEMETHYLASE; VORICONAZOLE;

ARTICLE; CANDIDA ALBICANS; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGEN BOND; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; NONHUMAN; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANTIFUNGAL AGENTS; AZOLES; BINDING SITES; COMPUTER SIMULATION; CYTOCHROME P-450 ENZYME SYSTEM; DRUG DESIGN; FLUCONAZOLE; FUNGAL PROTEINS; HYDROGEN BONDING; ITRACONAZOLE; MICROBIAL SENSITIVITY TESTS; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

CANDIDA ALBICANS; FUNGI;

EID: 70349214806     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.07.144     Document Type: Article

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