Three-dimensional model of lanosterol 14α-demethylase from Cryptococcus neoformans: Active-site characterization and insights into azole binding

Antimicrobial Agents and Chemotherapy

Volumn 53, Issue 8, 2009, Pages 3487-3495

  Sheng, Chunquan ^a   Miao, Zhenyuan ^a   Ji, Haitao ^b   Yao, Jianzhong ^a   Wang, Wenya ^a   Che, Xiaoying ^a   Dong, Guoqiang ^a   Lü, Jiaguo ^a   Guo, Wei ^a   Zhang, Wannian ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALBACONAZOLE; FLUCONAZOLE; HEME; ITRACONAZOLE; POSACONAZOLE; RAVUCONAZOLE; STEROL 14ALPHA DEMETHYLASE; VORICONAZOLE;

ARTICLE; CRYPTOCOCCUS NEOFORMANS; DRUG BINDING; DRUG DESIGN; DRUG STRUCTURE; MOLECULAR DOCKING; MOLECULAR DYNAMICS; PRIORITY JOURNAL; SIMULATION;

AMINO ACID SEQUENCE; ANTIFUNGAL AGENTS; AZOLES; CATALYTIC DOMAIN; COMPUTER SIMULATION; CRYPTOCOCCUS NEOFORMANS; CYTOCHROME P-450 ENZYME SYSTEM; FUNGAL PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; THERMODYNAMICS;

EID: 67749102047     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01630-08     Document Type: Article

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