Design, synthesis, and antifungal activity of novel conformationally restricted triazole derivatives

Archiv der Pharmazie

Volumn 342, Issue 12, 2009, Pages 732-739

  Wang, Wenya ^a   Sheng, Chunquan ^a   Che, Xiaoying ^a   Ji, Haitao ^b   Miao, Zhenyuan ^a   Yao, Jianzhong ^a   Zhang, Wannian ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Antifungal agents; Lanosterol demethylase; Molecular docking; Restricted analogues; Triazoles

Indexed keywords

1 (4 PHENOXYBUTYL)HEXAHYDROPYRIMIDINE; 1 AZIDO 2 (2,4 DIFLUOROPHENYL) 3 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 3 [1 (3 PHENOXYPROPYL)PIPERIDIN 4 YLIDENAMINO] 1 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 3 [1 (4 PHENOXYBUTYL)PIPERIDIN 4 YLIDENEAMINO] 1 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 3 [1 (5 PHENOXYPENTYL)PIPERIDIN 4 YLIDENAMINO] 1 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 3 [3 (3 PHENOXYPROPYL)TETRAHYDROPYRIMIDIN 1(2H) YL] 1 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 3 [3 (4 PHENOXYBUTYL)TETRAHYDROPYRIMIDIN 1(2H) YL] 1 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 3 [3 (5 PHENOXYPENTYL)TETRAHYDROPYRIMIDIN 1(2H) YL] 1 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 3 [METHYL (3 PHENOXYPROPYL) AMINO] 1 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 3 [METHYL (4 PHENOXYBUTYL) AMINO] 1 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 2 (2,4 DIFLUOROPHENYL) 3 [METHYL (5 PHENOXYPENTYL) AMINO] 1 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; N METHYL 4 PHENOXYBUTAN 1 AMINE; N1 (4 PHENOXYBUTYL)PROPANE 1,3 DIAMINE; STEROL 14ALPHA DEMETHYLASE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CONTROLLED STUDY; DRUG BINDING; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; NONHUMAN; PRIORITY JOURNAL;

ANTIFUNGAL AGENTS; BINDING SITES; CANDIDA ALBICANS; DRUG DESIGN; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 73449113660     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.200900103     Document Type: Article

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