Novel conformationally restricted triazole derivatives with potent antifungal activity

European Journal of Medicinal Chemistry

Volumn 45, Issue 12, 2010, Pages 6020-6026

  Wang, Wenya ^a   Wang, Shengzheng ^a   Liu, Yang ^a   Dong, Guoqiang ^a   Cao, Yongbing ^a   Miao, Zhenyuan ^a   Yao, Jianzhong ^a   Zhang, Wannian ^a   Sheng, Chunquan ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Antifungal activity; Azole; Conformationally restricted analogues; Molecular docking; Rational design

Indexed keywords

2 (2,4 DIFLUOROPHENYL) 3 [[1 (3 METHOXYBENZYL)PIPERIDIN 4 YL](METHYL)AMINO] 1 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 3 [(1 BENZYLPIPERIDIN 4 YL)(METHYL)AMINO] 2 (2,4 DIFLUOROPHENYL) 1 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 3 [[1 (2 CHLOROBENZYL)PIPERIDIN 4 YL](METHYL)AMINO] 2 (2,4 DIFLUOROPHENYL) 1 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 3 [[1 (2 FLUOROBENZYL)PIPERIDIN 4 YL](METHYL)AMINO] 2 (2,4 DIFLUOROPHENYL) 1 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 3 [[1 (2 METHYLBENZYL)PIPERIDIN 4 YL](METHYL)AMINO] 2 (2,4 DIFLUOROPHENYL) 1 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 3 [[1 (2,4 DICHLOROBENZYL)PIPERIDIN 4 YL](METHYL)AMINO] 2 (2,4 DIFLUOROPHENYL) 1 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 3 [[1 (3 BROMOBENZYL)PIPERIDIN 4 YL](METHYL)AMINO] 2 (2,4 DIFLUOROPHENYL) 1 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 3 [[1 (3 CHLOROBENZYL)PIPERIDIN 4 YL](METHYL)AMINO] 2 (2,4 DIFLUOROPHENYL) 1 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 3 [[1 (3,4 DICHLOROBENZYL)PIPERIDIN 4 YL](METHYL)AMINO] 2 (2,4 DIFLUOROPHENYL) 1 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 3 [[1 (4 BROMOBENZYL)PIPERIDIN 4 YL](METHYL)AMINO] 2 (2,4 DIFLUOROPHENYL) 1 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 3 [[1 (4 CYANOBENZYL)PIPERIDIN 4 YL](METHYL)AMINO] 2 (2,4 DIFLUOROPHENYL) 1 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 3 [[1 (4 FLUOROBENZYL)PIPERIDIN 4 YL](METHYL)AMINO] 2 (2,4 DIFLUOROPHENYL) 1 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 3 [[1 (4 ISOPROPYLBENZYL)PIPERIDIN 4 YL](METHYL)AMINO] 2 (2,4 DIFLUOROPHENYL) 1 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 3 [[1 (4 NITROBENZYL)PIPERIDIN 4 YL](METHYL)AMINO] 2 (2,4 DIFLUOROPHENYL) 1 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; FLUCONAZOLE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; DRUG DESIGN; DRUG SYNTHESIS; HYDROPHOBICITY; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANTIFUNGAL AGENTS; ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 78649317458     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.09.070     Document Type: Article

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