The GTPase-activating protein GIT2 protects against colitis by negatively regulating Toll-like receptor signaling

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 24, 2014, Pages 8883-8888

  Wei, Juncheng ^a,b,c   Wei, Chao ^a,b,c   Wang, Min ^b,c   Qiu, Xiao ^b,c,d   Li, Yang ^b   Yuan, Yanzhi ^b,c   Jin, Chaozhi ^b,c   Leng, Ling ^b,c   Wang, Jian ^b,c   Yang, Xiaoming ^b,c   He, Fuchu ^b,c  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^b BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

^c National Engineering Research Center for Protein Drugs   (China)

^d TSINGHUA UNIVERSITY   (China)

Author keywords

CYLD; GIT; IBD; TRAF6

Indexed keywords

CYTOKINE; ENDOTOXIN; G PROTEIN COUPLED RECEPTOR; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN GIT2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 17; INTERLEUKIN 6; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CROHN DISEASE; CYTOKINE RELEASE; DEXTRAN SODIUM SULFATE-INDUCED COLITIS; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INFLAMMATORY BOWEL DISEASE; KNOCKOUT MOUSE; MACROPHAGE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SEPTIC SHOCK; UBIQUITINATION; ULCERATIVE COLITIS;

CYLD; GIT; IBD; TRAF6;

ADENOSINE DIPHOSPHATE; ANIMALS; CELL CYCLE PROTEINS; COLITIS; CYSTEINE ENDOPEPTIDASES; ENDOTOXINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; GTP PHOSPHOHYDROLASES; HEK293 CELLS; HUMANS; INFLAMMATION; MICE; MICE, KNOCKOUT; MYELOID DIFFERENTIATION FACTOR 88; NEUTROPHILS; NF-KAPPA B; PHOSPHOPROTEINS; SEPSIS; SIGNAL TRANSDUCTION; THYMOCYTES; TNF RECEPTOR-ASSOCIATED FACTOR 6; TOLL-LIKE RECEPTORS;

EID: 84902596860     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1309218111     Document Type: Article

References (35)

1. AbrahamC, Cho JH (2009) Inflammatory bowel disease. N Engl JMed 361(21):2066-2078.
2. Danese S, Fiocchi C (2011) Ulcerative colitis. N Engl J Med 365(18):1713-1725.
3. Saleh M, Elson CO (2011) Experimental inflammatory bowel disease: Insights into the host-microbiota dialog. Immunity 34(3):293-302.
4. Rakoff-Nahoum S, Hao L, Medzhitov R (2006) Role of toll-like receptors in spontaneous commensal-dependent colitis. Immunity 25(2):319-329. (Pubitemid 44224143)
5. Murray PJ, Smale ST (2012) Restraint of inflammatory signaling by interdependent strata of negative regulatory pathways. Nat Immunol 13(10):916-924.
6. Li HY, et al. (2008) Deactivation of the kinase IKK by CUEDC2 through recruitment of the phosphatase PP1. Nat Immunol 9(5):533-541.
7. Marshak-Rothstein A (2006) Toll-like receptors in systemic autoimmune disease. Nat Rev Immunol 6(11):823-835.
8. Cook DN, Pisetsky DS, Schwartz DA (2004) Toll-like receptors in the pathogenesis of human disease. Nat Immunol 5(10):975-979. (Pubitemid 41057713)
9. Trompouki E, et al. (2003) CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members. Nature 424(6950):793-796. (Pubitemid 37021710)
10. Kovalenko A, et al. (2003) The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination. Nature 424(6950):801-805. (Pubitemid 37021712)
11. Xia ZP, et al. (2009) Direct activation of protein kinases by unanchored polyubiquitin chains. Nature 461(7260):114-119.
12. Trompouki E, et al. (2009) Truncation of the catalytic domain of the cylindromatosis tumor suppressor impairs lung maturation. Neoplasia 11(5):469-476.
13. Inoue H, Randazzo PA (2007) Arf GAPs and their interacting proteins. Traffic 8(11): 1465-1475. (Pubitemid 47591332)
14. Premont RT, Claing A, Vitale N, Perry SJ, Lefkowitz RJ (2000) The GIT family of ADPribosylation factor GTPase-activating proteins: Functional diversity of GIT2 through alternative splicing. J Biol Chem 275(29):22373-22380. (Pubitemid 30621823)
15. Ku GM, Yablonski D, Manser E, Lim L, Weiss A (2001) A PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT. EMBO J 20(3):457-465. (Pubitemid 32126981)
16. Mazaki Y, et al. (2006) Neutrophil direction sensing and superoxide production linked by the GTPase-activating protein GIT2. Nat Immunol 7(7):724-731. (Pubitemid 43905871)
17. Phee H, et al. (2010) Regulation of thymocyte positive selection and motility by GIT2. Nat Immunol 11(6):503-511.
18. Su AI, et al. (2004) A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci USA 101(16):6062-6067. (Pubitemid 38520528)
19. Orozco LD, et al. (2012) Unraveling inflammatory responses using systems genetics and gene-environment interactions in macrophages. Cell 151(3):658-670.
20. Wang J, et al. (2011) Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol 7:536.
21. Knutson CG, et al. (2013) Chemical and cytokine features of innate immunity characterize serum and tissue profiles in inflammatory bowel disease. Proc Natl Acad Sci USA 110(26):E2332-E2341.
22. Haziot A, et al. (1996) Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice. Immunity 4(4):407-414. (Pubitemid 26174055)
23. Han C, et al. (2010) Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b. Nat Immunol 11(8):734-742.
24. Xu S, et al. (2012) Constitutive MHC class I molecules negatively regulate TLR-triggered inflammatory responses via the Fps-SHP-2 pathway. Nat Immunol 13(6):551-559.
25. Seibert K, Masferrer JL (1994) Role of inducible cyclooxygenase (COX-2) in inflammation. Receptor 4(1):17-23.
26. Lomaga MA, et al. (1999) TRAF6 deficiency results in osteopetrosis and defective in-terleukin- 1, CD40, and LPS signaling. Genes Dev 13(8):1015-1024. (Pubitemid 29200984)
27. Wang Y, et al. (2006) Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol 7(2):139-147. (Pubitemid 43135879)
28. Massoumi R (2010) Ubiquitin chain cleavage: CYLD at work. Trends Biochem Sci 35(7): 392-399.
29. Turner CE, et al. (1999) Paxillin LD4motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling. J Cell Biol 145(4):851-863. (Pubitemid 29240860)
30. Lin KM, et al. (2014) IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation. Proc Natl Acad Sci USA 111(2):775-780.
31. Asquith MJ, Boulard O, Powrie F, Maloy KJ (2010) Pathogenic and protective roles of MyD88 in leukocytes and epithelial cells in mouse models of inflammatory bowel disease. Gastroenterology 139(2):519-529, 529.e1-529.e2.
32. Brandl K, et al. (2010) MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands. Proc Natl Acad Sci USA 107(46):19967-19972.
33. Zlotnik A, Yoshie O (2012) The chemokine superfamily revisited. Immunity 36(5): 705-716.
34. Adachi O, et al. (1998) Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 9(1):143-150. (Pubitemid 28361303)
35. Liu Z, et al. (2011) The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease. Nat Immunol 12(11): 1063-1070.