-
1
-
-
0028034775
-
Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb
-
Li Y, Nichols MA, Shay JW and Xiong Y: Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb. Cancer Res 54: 6078-6082, 1994.
-
(1994)
Cancer Res
, vol.54
, pp. 6078-6082
-
-
Li, Y.1
Nichols, M.A.2
Shay, J.W.3
Xiong, Y.4
-
2
-
-
0342547019
-
Anticoagulant fucoidan fractions from Fucus vesiculosus induce platelet activation in vitro
-
Dürig J, Vruhn T, Zurborn KH, Gutensohn K, Bruhn HD and Bėress L: Anticoagulant fucoidan fractions from Fucus vesiculosus induce platelet activation in vitro. Thromb Res 85: 479-491, 1997.
-
(1997)
Thromb Res
, vol.85
, pp. 479-491
-
-
Dürig, J.1
Vruhn, T.2
Zurborn, K.H.3
Gutensohn, K.4
Bruhn, H.D.5
Beress, L.6
-
3
-
-
0041621601
-
Antitumor activity and immune response of Mekabu fucoidan extracted from Sporophyll of Undaria pinnatifida
-
Maruyama H, Tamauchi H, Hasimoto M and Nakano T: Antitumor activity and immune response of Mekabu fucoidan extracted from Sporophyll of Undaria pinnatifida. In vivo 17: 245-249, 2003.
-
(2003)
In Vivo
, vol.17
, pp. 245-249
-
-
Maruyama, H.1
Tamauchi, H.2
Hasimoto, M.3
Nakano, T.4
-
4
-
-
38349164399
-
Antioxidant activity of sulfated polysaccharide fractions extracted from Laminaria japonica
-
Wang J, Zhang Q, Zang Z and Li Z: Antioxidant activity of sulfated polysaccharide fractions extracted from Laminaria japonica. Int J Biol Macromol 42: 127-132, 2008.
-
(2008)
Int J Biol Macromol
, vol.42
, pp. 127-132
-
-
Wang, J.1
Zhang, Q.2
Zang, Z.3
Li, Z.4
-
5
-
-
77949330371
-
Antioxidant activity of sulfated polysaccharide fractions extracted from Undaria pinnitafida in vitro
-
Hu T, Liu D, Chen Y, Wu J and Wang S: Antioxidant activity of sulfated polysaccharide fractions extracted from Undaria pinnitafida in vitro. Int J Biol Macromol 46: 193-198, 2010.
-
(2010)
Int J Biol Macromol
, vol.46
, pp. 193-198
-
-
Hu, T.1
Liu, D.2
Chen, Y.3
Wu, J.4
Wang, S.5
-
6
-
-
84870615277
-
Fucoidan form seaweed Fucus vesiculosus inhibits migration and invasion of human lung cancer cells via PI3K-Akt-mTOR pathways
-
Lee H, Kim JS and Kim E: Fucoidan form seaweed Fucus vesiculosus inhibits migration and invasion of human lung cancer cells via PI3K-Akt-mTOR pathways. PLoS One 7: e50624, 2012.
-
(2012)
PLoS One
, vol.7
-
-
Lee, H.1
Kim, J.S.2
Kim, E.3
-
7
-
-
84865175152
-
Anticancer properties and mechanisms of fucoidan on mouse breast cancer in vitro and in vivo
-
Xue M, Ge Y, Zhang J, et al: Anticancer properties and mechanisms of fucoidan on mouse breast cancer in vitro and in vivo. PLoS One 7: e43483, 2012.
-
(2012)
PLoS One
, vol.7
-
-
Xue, M.1
Ge, Y.2
Zhang, J.3
-
8
-
-
84859075793
-
Cisplatin-based combination chemotherapy for advanced hepatocellular carcinoma: A single centre experience before the sorafenib era
-
Kim NY, Sun JM, Kim YJ, et al: Cisplatin-based combination chemotherapy for advanced hepatocellular carcinoma: a single centre experience before the sorafenib era. Cancer Res Treat 42: 203-209, 2010.
-
(2010)
Cancer Res Treat
, vol.42
, pp. 203-209
-
-
Kim, N.Y.1
Sun, J.M.2
Kim, Y.J.3
-
9
-
-
84857504660
-
Cellular senescence and tumor suppressor gene p16
-
Rayess H, Wang MB and Srivatsan ES: Cellular senescence and tumor suppressor gene p16. Int J Cancer 130: 1715-1725, 2012.
-
(2012)
Int J Cancer
, vol.130
, pp. 1715-1725
-
-
Rayess, H.1
Wang, M.B.2
Srivatsan, E.S.3
-
11
-
-
0033013980
-
Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts
-
Stein GH, Drullinger LF, Soulard A and Dulić V: Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts. Mol Cell Biol 19: 2109-2117, 1999.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 2109-2117
-
-
Stein, G.H.1
Drullinger, L.F.2
Soulard, A.3
Dulić, V.4
-
12
-
-
50949098274
-
Fucoidan: Structure and bioactivity
-
Li B, Lu F, Wei X and Zhao R: Fucoidan: structure and bioactivity. Molecules 13: 1671-1695, 2008.
-
(2008)
Molecules
, vol.13
, pp. 1671-1695
-
-
Li, B.1
Lu, F.2
Wei, X.3
Zhao, R.4
-
13
-
-
0029670840
-
Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence
-
Hara E, Smith R, Parry D, Tahara H, Stone S and Peters G: Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence. Mol Cell Biol 16: 859-867, 2008.
-
(2008)
Mol Cell Biol
, vol.16
, pp. 859-867
-
-
Hara, E.1
Smith, R.2
Parry, D.3
Tahara, H.4
Stone, S.5
Peters, G.6
-
14
-
-
0030778842
-
Arf
-
Arf. Cell 91: 555-558, 1997.
-
(1997)
Cell
, vol.91
, pp. 555-558
-
-
Haber, D.A.1
-
17
-
-
22144489899
-
INK4a/ARF: A multifunctional tumor suppressor locus
-
Sharpless NE: INK4a/ARF: A multifunctional tumor suppressor locus. Mutat Res 576: 22-38, 2005.
-
(2005)
Mutat Res
, vol.576
, pp. 22-38
-
-
Sharpless, N.E.1
-
18
-
-
34547212349
-
The pathways to tumor suppression via route p38
-
2007
-
Han J and Sun P: 2007. The pathways to tumor suppression via route p38. Trends Biochem Sci 32: 364-371, 2007.
-
(2007)
Trends Biochem Sci
, vol.32
, pp. 364-371
-
-
Han, J.1
Sun, P.2
-
19
-
-
7644223136
-
p38 MAPK kinase's emerging role as a tumor suppressor
-
Bulavin DV and Fornace AJ Jr: p38 MAPK kinase's emerging role as a tumor suppressor. Adv Cancer Res 92: 95-118, 2004.
-
(2004)
Adv Cancer Res
, vol.92
, pp. 95-118
-
-
Bulavin, D.V.1
Fornace Jr., A.J.2
-
21
-
-
1342329228
-
mRNA level of alpha-2-macroglobulin as an aging biomarker of human fibroblasts in culture
-
Ma H, Li R, Zhang Z and Tong T: mRNA level of alpha-2-macroglobulin as an aging biomarker of human fibroblasts in culture. Exp Gerontol 39: 415-421, 2004.
-
(2004)
Exp Gerontol
, vol.39
, pp. 415-421
-
-
Ma, H.1
Li, R.2
Zhang, Z.3
Tong, T.4
-
22
-
-
0034064361
-
The INK4a/ARF locus in murine tumorigenesis
-
Serrano M: The INK4a/ARF locus in murine tumorigenesis. Carcinogenesis 21: 865-869, 2000.
-
(2000)
Carcinogenesis
, vol.21
, pp. 865-869
-
-
Serrano, M.1
-
23
-
-
0037013154
-
INK4a contributes to the outcome of cancer therapy
-
INK4a contributes to the outcome of cancer therapy. Cell 109: 335-346, 2002.
-
(2002)
Cell
, vol.109
, pp. 335-346
-
-
Schmitt, C.A.1
Fridman, J.S.2
Yang, M.3
-
24
-
-
79960802666
-
Gold from the sea: Marine compounds as inhibitors of the hallmarks of cancer
-
Schumacher M, Kelkel M, Dicato M and Diederich M: Gold from the sea: marine compounds as inhibitors of the hallmarks of cancer. Biotechnol Adv 29: 531-547, 2011.
-
(2011)
Biotechnol Adv
, vol.29
, pp. 531-547
-
-
Schumacher, M.1
Kelkel, M.2
Dicato, M.3
Diederich, M.4
-
25
-
-
54949117172
-
Cancer stem cells and chemoradiation resistance
-
Ishii H, Iwatsuki M, Ieta K, et al: Cancer stem cells and chemoradiation resistance. Cancer Sci 99: 1871-1877, 2008.
-
(2008)
Cancer Sci
, vol.99
, pp. 1871-1877
-
-
Ishii, H.1
Iwatsuki, M.2
Ieta, K.3
-
26
-
-
35649022182
-
Antitumor and antimetastatic activity of fucoidan, a sulfated polysaccharide isolated from the Okhotsk Sea Fucus evanescens brown alga
-
Alekseyenko TV, Zhanayeva SY, Venediktova AA, et al: Antitumor and antimetastatic activity of fucoidan, a sulfated polysaccharide isolated from the Okhotsk Sea Fucus evanescens brown alga. Bull Exp Biol Med 143: 730-732, 2007.
-
(2007)
Bull Exp Biol Med
, vol.143
, pp. 730-732
-
-
Alekseyenko, T.V.1
Zhanayeva, S.Y.2
Venediktova, A.A.3
-
27
-
-
70349438994
-
Tumour suppression by p53: A role for the DNA damage response?
-
2009
-
Meek DW: 2009. Tumour suppression by p53: a role for the DNA damage response? Nat Rev Cancer 9: 714-723, 2009.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 714-723
-
-
Meek, D.W.1
-
28
-
-
33748327046
-
INK4a is a robust in vivo biomarker of cellular aging in human skin
-
INK4a is a robust in vivo biomarker of cellular aging in human skin. Aging Cell 5: 379-389, 2006.
-
(2006)
Aging Cell
, vol.5
, pp. 379-389
-
-
Ressler, S.1
Bartkova, J.2
Niederegger, H.3
-
29
-
-
42649086167
-
Genetic polymorphisms and human aging: Association studies deliver
-
Melzer D: Genetic polymorphisms and human aging: association studies deliver. Rejuvenation Res 11: 523-526, 2008.
-
(2008)
Rejuvenation Res
, vol.11
, pp. 523-526
-
-
Melzer, D.1
-
30
-
-
34250852375
-
Dactylone inhibits epidermal growth factor-induced transformation and phenotype expression of human cancer cells and induces G1-S arrest and apoptosis
-
Fedorov SN, Shubina LK, Bode AM, Stonik VA and Dong Z: Dactylone inhibits epidermal growth factor-induced transformation and phenotype expression of human cancer cells and induces G1-S arrest and apoptosis. Cancer Res 67: 5914-5920, 2007.
-
(2007)
Cancer Res
, vol.67
, pp. 5914-5920
-
-
Fedorov, S.N.1
Shubina, L.K.2
Bode, A.M.3
Stonik, V.A.4
Dong, Z.5
-
31
-
-
33750742425
-
Suppression of U937 human monocytic leukemia cell growth by dideoxypetrosynol A, a polyacetylene from the sponge Petrosia sp., via induction of Cdk inhibitor p16 and down-regulation of pRB phosphorylation
-
Park C, Kim GY, Kim GD, et al: Suppression of U937 human monocytic leukemia cell growth by dideoxypetrosynol A, a polyacetylene from the sponge Petrosia sp., via induction of Cdk inhibitor p16 and down-regulation of pRB phosphorylation. Oncol Rep 16: 171-176, 2006.
-
(2006)
Oncol Rep
, vol.16
, pp. 171-176
-
-
Park, C.1
Kim, G.Y.2
Kim, G.D.3
-
32
-
-
0040419494
-
Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53
-
Müller M, Strand S, Hug H, et al: Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53. J Clin Invest 99: 403-413, 1997.
-
(1997)
J Clin Invest
, vol.99
, pp. 403-413
-
-
Müller, M.1
Strand, S.2
Hug, H.3
-
34
-
-
34548397587
-
Reduced expression of INK4a/ARF genes in stem-like sphere cells from rat sarcomas
-
Fujii H, Honoki K, Tsujiuchi T, et al: Reduced expression of INK4a/ARF genes in stem-like sphere cells from rat sarcomas. Biochem Biophysic Res Commun 362: 773-778, 2007.
-
(2007)
Biochem Biophysic Res Commun
, vol.362
, pp. 773-778
-
-
Fujii, H.1
Honoki, K.2
Tsujiuchi, T.3
-
35
-
-
54049113056
-
Involvement of p38 mitogen-activated protein kinase pathway in honokiol-induced apoptosis in a human hepatoma cell line (HepG2)
-
Deng J, Qian Y, Geng L, et al: Involvement of p38 mitogen-activated protein kinase pathway in honokiol-induced apoptosis in a human hepatoma cell line (HepG2). Liver Int 28: 1458-1464, 2008.
-
(2008)
Liver Int
, vol.28
, pp. 1458-1464
-
-
Deng, J.1
Qian, Y.2
Geng, L.3
-
36
-
-
77951621847
-
Activation and clinical significance of p38 MAPK signaling pathway in patients with severe trauma
-
Wang YX, Xu XY, Su WL, et al: Activation and clinical significance of p38 MAPK signaling pathway in patients with severe trauma. J Surg Res 161: 119-125, 2009.
-
(2009)
J Surg Res
, vol.161
, pp. 119-125
-
-
Wang, Y.X.1
Xu, X.Y.2
Su, W.L.3
-
37
-
-
70349956623
-
Apoptosis inducing activity of fucoidan in HCT-15 colon carcinoma cells
-
Hyun JH, Kim SC, Kang JI, et al: Apoptosis inducing activity of fucoidan in HCT-15 colon carcinoma cells. Biol Pharm Bull 32: 1760-1764, 2009.
-
(2009)
Biol Pharm Bull
, vol.32
, pp. 1760-1764
-
-
Hyun, J.H.1
Kim, S.C.2
Kang, J.I.3
-
38
-
-
0038390661
-
Involvement of the p38 mitogen-activated protein kinase cascade in hepatocellular carcinoma
-
Iyoda K, Sasaki Y, Horimoto M, et al: Involvement of the p38 mitogen-activated protein kinase cascade in hepatocellular carcinoma. Cancer 97: 3017-3026, 2003.
-
(2003)
Cancer
, vol.97
, pp. 3017-3026
-
-
Iyoda, K.1
Sasaki, Y.2
Horimoto, M.3
-
39
-
-
67749117934
-
Signal integration by JNK and p38 MAPK pathways in cancer development
-
Wagner EF and Nebreda AR: Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer 9: 537-549, 2009.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 537-549
-
-
Wagner, E.F.1
Nebreda, A.R.2
-
40
-
-
51649114209
-
Spongistatin 1: A new chemosensitizing marine compound that degrades XIAP
-
Schyschka L, Rudy A, Jeremias I, Barth N, Pettit GR and Vollmar AM: Spongistatin 1: a new chemosensitizing marine compound that degrades XIAP. Leukemia 22: 1737-1745, 2008.
-
(2008)
Leukemia
, vol.22
, pp. 1737-1745
-
-
Schyschka, L.1
Rudy, A.2
Jeremias, I.3
Barth, N.4
Pettit, G.R.5
Vollmar, A.M.6
-
41
-
-
0036547417
-
Death and anti-death: Tumor resistance to apoptosis
-
Igney FH and Krammer PH: Death and anti-death: tumor resistance to apoptosis. Nat Rev Cancer 2: 277-288, 2002.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 277-288
-
-
Igney, F.H.1
Krammer, P.H.2
-
42
-
-
57349119915
-
Accelerated senescence in the kidneys of patients with type 2 diabetic nephropathy
-
Verzola D, Gandolfo MT, Gaetani G, et al: Accelerated senescence in the kidneys of patients with type 2 diabetic nephropathy. Am J Physiol Renal Physiol 295: F1563-F1573, 2008.
-
(2008)
Am J Physiol Renal Physiol
, vol.295
-
-
Verzola, D.1
Gandolfo, M.T.2
Gaetani, G.3
-
44
-
-
0033049828
-
INK4a and the control of cellular proliferative life span
-
INK4a and the control of cellular proliferative life span. Carcinogenesis 20: 921-926, 1999.
-
(1999)
Carcinogenesis
, vol.20
, pp. 921-926
-
-
Huschtscha, L.I.1
Reddel, R.R.2
-
47
-
-
77951985216
-
Examination of the expanding pathway for the regulation of p21 expression and activity
-
Jung YS, Qian Y and Chen X: Examination of the expanding pathway for the regulation of p21 expression and activity. Cell Signal 22: 1003-1012, 2010.
-
(2010)
Cell Signal
, vol.22
, pp. 1003-1012
-
-
Jung, Y.S.1
Qian, Y.2
Chen, X.3
-
48
-
-
34447543913
-
Cellular senescence in cancer and aging
-
Collado M, Blasco MA and Serrano M: Cellular senescence in cancer and aging. Cell 130: 223-233, 2007.
-
(2007)
Cell
, vol.130
, pp. 223-233
-
-
Collado, M.1
Blasco, M.A.2
Serrano, M.3
-
49
-
-
0028946009
-
Increase in the expression level of p21sdi1/cip1/waf1 with increasing division age in both normal and SV40-transformed human fibroblasts
-
Tahara H, Sato E, Noda A and Ide T: Increase in the expression level of p21sdi1/cip1/waf1 with increasing division age in both normal and SV40-transformed human fibroblasts. Oncogene 10: 835-840, 1995.
-
(1995)
Oncogene
, vol.10
, pp. 835-840
-
-
Tahara, H.1
Sato, E.2
Noda, A.3
Ide, T.4
-
50
-
-
0035096154
-
Two-dimensional gel electrophoresis studies on the cellular aging: Accumulation of alpha-2-macroglobulin in human fibroblasts with aging
-
Kondo T, Sakaguchi M, and Namba M: Two-dimensional gel electrophoresis studies on the cellular aging: accumulation of alpha-2-macroglobulin in human fibroblasts with aging. Exp Gerontol 36: 487-495, 2001.
-
(2001)
Exp Gerontol
, vol.36
, pp. 487-495
-
-
Kondo, T.1
Sakaguchi, M.2
Namba, M.3
|