메뉴 건너뛰기




Volumn 39, Issue 3, 2004, Pages 415-421

mRNA level of alpha-2-macroglobulin as an aging biomarker of human fibroblasts in culture

Author keywords

Alpha 2 macroglobulin; Alzheimer's disease; Biomarker; cDNA array; Cellular aging; Fibroblasts; Gene expression; In vitro; Population doubling; RT PCR

Indexed keywords

ALPHA 2 MACROGLOBULIN; BIOLOGICAL MARKER; COMPLEMENTARY DNA; HYDROGEN PEROXIDE; MESSENGER RNA;

EID: 1342329228     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2003.11.012     Document Type: Article
Times cited : (15)

References (40)
  • 1
    • 0025970571 scopus 로고
    • Increased gene expression of Alzheimer disease beta-amyloid precursor protein in senescent cultured fibroblasts
    • Alder M.J., Coronel C., Shelton E., Seegmiller J.E., Dewji N.N. Increased gene expression of Alzheimer disease beta-amyloid precursor protein in senescent cultured fibroblasts. Proc. Natl Acad. Sci. USA. 88:1991;16-20.
    • (1991) Proc. Natl Acad. Sci. USA , vol.88 , pp. 16-20
    • Alder, M.J.1    Coronel, C.2    Shelton, E.3    Seegmiller, J.E.4    Dewji, N.N.5
  • 4
    • 0032531126 scopus 로고    scopus 로고
    • Premature induction of aging in sublethally H2O2-treated young MRC5 fibroblasts correlates with increased glutathione peroxidase levels and resistance to DNA breakage
    • Caldini R., Chevanne M., Mocali A., Tombaccini D., Paoletti F. Premature induction of aging in sublethally H2O2-treated young MRC5 fibroblasts correlates with increased glutathione peroxidase levels and resistance to DNA breakage. Mech. Ageing Dev. 105:1998;137-150.
    • (1998) Mech. Ageing Dev. , vol.105 , pp. 137-150
    • Caldini, R.1    Chevanne, M.2    Mocali, A.3    Tombaccini, D.4    Paoletti, F.5
  • 5
    • 0035325264 scopus 로고    scopus 로고
    • Uncoupling the senescent phenotype from telomere shortening in hydrogen peroxide-treated fibroblasts
    • Chen Q.M., Prowse K.R., Tu V.C., Purdom S., Linskens M.H. Uncoupling the senescent phenotype from telomere shortening in hydrogen peroxide-treated fibroblasts. Exp. Cell Res. 265:2001;294-303.
    • (2001) Exp. Cell Res. , vol.265 , pp. 294-303
    • Chen, Q.M.1    Prowse, K.R.2    Tu, V.C.3    Purdom, S.4    Linskens, M.H.5
  • 6
    • 0025185228 scopus 로고
    • Age-dependent decrease in heat-inducible DNA sequence-specific binding activity in human diploid fibroblasts
    • Choi H.S., Lin Z., Li B.S., Liu A.Y. Age-dependent decrease in heat-inducible DNA sequence-specific binding activity in human diploid fibroblasts. J. Biol. Chem. 265:1990;18005-18011.
    • (1990) J. Biol. Chem. , vol.265 , pp. 18005-18011
    • Choi, H.S.1    Lin, Z.2    Li, B.S.3    Liu, A.Y.4
  • 7
    • 0029006174 scopus 로고
    • Alterations in the molecular response to DNA damage during cellular aging of cultured fibroblasts: Reduced Ap-1activation and collagenase gene expression
    • Choi A.M.K., Pignolo R.J., Rhys C.M.J., Cristifalo V.J., Holbrook N.J. Alterations in the molecular response to DNA damage during cellular aging of cultured fibroblasts: reduced Ap-1activation and collagenase gene expression. J. Cell Physiol. 164:1995;65-74.
    • (1995) J. Cell Physiol. , vol.164 , pp. 65-74
    • Choi, A.M.K.1    Pignolo, R.J.2    Rhys, C.M.J.3    Cristifalo, V.J.4    Holbrook, N.J.5
  • 8
    • 0028174104 scopus 로고
    • Classification of alpha 2-macroglobulin-cytokine interactions based on affinity of noncovalent association in solution under apparent equilibrium conditions
    • Crookston K.P., Webb D.J., Wolf B.B., Gonias S.L.J. Classification of alpha 2-macroglobulin-cytokine interactions based on affinity of noncovalent association in solution under apparent equilibrium conditions. J. Biol. Chem. 269:1994;1533-1540.
    • (1994) J. Biol. Chem. , vol.269 , pp. 1533-1540
    • Crookston, K.P.1    Webb, D.J.2    Wolf, B.B.3    Gonias, S.L.J.4
  • 9
    • 0026800776 scopus 로고
    • Overexpression of two-chain form of cathepsin B in senescent WI-38 cells
    • DiPaolo B.R., Pignolo R.J., Cristifalo V.J. Overexpression of two-chain form of cathepsin B in senescent WI-38 cells. Exp. Cell Res. 201:1992;500-505.
    • (1992) Exp. Cell Res. , vol.201 , pp. 500-505
    • Dipaolo, B.R.1    Pignolo, R.J.2    Cristifalo, V.J.3
  • 13
    • 0035951791 scopus 로고    scopus 로고
    • 2 stress triggers a release of transforming growth factor-beta 1, which induces biomarkers of cellular senescence of human diploid fibroblasts
    • 2 stress triggers a release of transforming growth factor-beta 1, which induces biomarkers of cellular senescence of human diploid fibroblasts. J. Biol. Chem. 276:2001;2531-2537.
    • (2001) J. Biol. Chem. , vol.276 , pp. 2531-2537
    • Frippiat, C.1    Chen, Q.M.2    Zdanov, S.3    Magalhaes, J.P.4    Remacle, J.5    Toussaint, O.6
  • 14
    • 0025145238 scopus 로고
    • Replicative senescence: The human fibroblast comes of age
    • Goldstein S. Replicative senescence: the human fibroblast comes of age. Science. 249:1990;1129-1133.
    • (1990) Science , vol.249 , pp. 1129-1133
    • Goldstein, S.1
  • 16
    • 50549218525 scopus 로고
    • The limited in vitro lifetime of human diploid strains
    • Hayflick L. The limited in vitro lifetime of human diploid strains. Exp. Cell Res. 37:1965;614-636.
    • (1965) Exp. Cell Res. , vol.37 , pp. 614-636
    • Hayflick, L.1
  • 18
    • 0035096154 scopus 로고    scopus 로고
    • Two-dimensional gel electrophoretic studies on the cellular aging: Accumulation of alpha-2-macroglobulin in human fibroblasts with aging
    • Kondo T., Sakaguchi M., Namba M. Two-dimensional gel electrophoretic studies on the cellular aging: accumulation of alpha-2-macroglobulin in human fibroblasts with aging. Exp. Gerontol. 36:2001;487-495.
    • (2001) Exp. Gerontol. , vol.36 , pp. 487-495
    • Kondo, T.1    Sakaguchi, M.2    Namba, M.3
  • 19
    • 0031732328 scopus 로고    scopus 로고
    • Expression profile of senescence-associated beta-galactosidase and activation of telomerase in human ovarian surface epithelial cells undergoing immortalization
    • Litaker J.R., Pan J., Cheung Y., Zhang D.K., Liu Y., Wong S.C. Expression profile of senescence-associated beta-galactosidase and activation of telomerase in human ovarian surface epithelial cells undergoing immortalization. Int. J. Oncol. 13:1998;951-956.
    • (1998) Int. J. Oncol. , vol.13 , pp. 951-956
    • Litaker, J.R.1    Pan, J.2    Cheung, Y.3    Zhang, D.K.4    Liu, Y.5    Wong, S.C.6
  • 20
    • 0035824641 scopus 로고    scopus 로고
    • Identification of the high affinity binding site in transforming growth factor-beta involved in complex formation with alpha 2-macroglobulin. Implications regarding the molecular mechanisms of complex formation between alpha 2-macroglobulin and growth factors, cytokines, and hormones
    • Liu Q., Ling T.Y., Shieh H.S., Johnson F.E., Huang S.S. Identification of the high affinity binding site in transforming growth factor-beta involved in complex formation with alpha 2-macroglobulin. Implications regarding the molecular mechanisms of complex formation between alpha 2-macroglobulin and growth factors, cytokines, and hormones. J. Biol. Chem. 276:2001;46212-46218.
    • (2001) J. Biol. Chem. , vol.276 , pp. 46212-46218
    • Liu, Q.1    Ling, T.Y.2    Shieh, H.S.3    Johnson, F.E.4    Huang, S.S.5
  • 22
    • 0036765026 scopus 로고    scopus 로고
    • The effects of epidermal growth factor on gene expression in human fibroblasts
    • Ma H., Zhang Z.Y., Tong T.J. The effects of epidermal growth factor on gene expression in human fibroblasts. In Vitro Cell Dev. Biol. Anim. 38:2002;481-486.
    • (2002) In Vitro Cell Dev. Biol. Anim. , vol.38 , pp. 481-486
    • Ma, H.1    Zhang, Z.Y.2    Tong, T.J.3
  • 24
    • 0014816132 scopus 로고
    • Replicative lifespan of cultivated human cells. Effects of dornor's age, tissue and genotype
    • Martin G.M., Sparague C.A., Epstein C.J. Replicative lifespan of cultivated human cells. Effects of dornor's age, tissue and genotype. Lab Invest. 23:1970;86-92.
    • (1970) Lab Invest. , vol.23 , pp. 86-92
    • Martin, G.M.1    Sparague, C.A.2    Epstein, C.J.3
  • 25
    • 0037066773 scopus 로고    scopus 로고
    • Distinct binding sites in the structure of alpha 2-macroglobulin mediate the interaction with beta-amyloid peptide and growth factors
    • Mettenburg J.M., Webb D.J., Gonias S.L. Distinct binding sites in the structure of alpha 2-macroglobulin mediate the interaction with beta-amyloid peptide and growth factors. J. Biol. Chem. 277:2002;13338-13345.
    • (2002) J. Biol. Chem. , vol.277 , pp. 13338-13345
    • Mettenburg, J.M.1    Webb, D.J.2    Gonias, S.L.3
  • 26
    • 0037040284 scopus 로고    scopus 로고
    • Regulation of cytosolic phospholipase A2 activity in macrophages stimulated with receptor-recognized forms of alpha 2-macroglobulin: Role in mitogenesis and cell proliferation
    • Misra U.K., Pizzo S.V. Regulation of cytosolic phospholipase A2 activity in macrophages stimulated with receptor-recognized forms of alpha 2-macroglobulin: role in mitogenesis and cell proliferation. J. Biol. Chem. 277:2002;4069-4078.
    • (2002) J. Biol. Chem. , vol.277 , pp. 4069-4078
    • Misra, U.K.1    Pizzo, S.V.2
  • 27
    • 0027502881 scopus 로고
    • Senescent WI-38 cells fail to express EPC-1, a gene induced in young cells upon entry into the G0 state
    • Pignolo R.J., Cristifalo V.J., Rotenberg M.O. Senescent WI-38 cells fail to express EPC-1, a gene induced in young cells upon entry into the G0 state. J. Biol. Chem. 268:1993;8949-8957.
    • (1993) J. Biol. Chem. , vol.268 , pp. 8949-8957
    • Pignolo, R.J.1    Cristifalo, V.J.2    Rotenberg, M.O.3
  • 28
    • 0027502881 scopus 로고
    • Senescent WI-38 cells fail to express EPC-1, a gene induced in young cells upon entry into the G0 state
    • Pignolo R.J., Cristofalo V.J., Rotenberg M.O. Senescent WI-38 cells fail to express EPC-1, a gene induced in young cells upon entry into the G0 state. J. Biol. Chem. 268:1993;8949-8957.
    • (1993) J. Biol. Chem. , vol.268 , pp. 8949-8957
    • Pignolo, R.J.1    Cristofalo, V.J.2    Rotenberg, M.O.3
  • 29
    • 0032589297 scopus 로고    scopus 로고
    • Alpha2-macroglobulin enhances the clearance of endogenous soluble beta-amyloid peptide via low-density lipoprotein receptor-related protein in cortical neurons
    • Qiu Z., Strickland D.K., Hyman B.T., Rebeck G.W. Alpha2-macroglobulin enhances the clearance of endogenous soluble beta-amyloid peptide via low-density lipoprotein receptor-related protein in cortical neurons. J. Neurochem. 73:1999;1393-1398.
    • (1999) J. Neurochem. , vol.73 , pp. 1393-1398
    • Qiu, Z.1    Strickland, D.K.2    Hyman, B.T.3    Rebeck, G.W.4
  • 30
    • 0000299214 scopus 로고
    • Evidence for a relationship between longevity of mammalian species and life spans of normal fibroblasts in vitro and erythrocytes in vivo
    • Rohme D. Evidence for a relationship between longevity of mammalian species and life spans of normal fibroblasts in vitro and erythrocytes in vivo. Proc. Natl Acad. Sci. USA. 78:1986;5009-5013.
    • (1986) Proc. Natl Acad. Sci. USA , vol.78 , pp. 5009-5013
    • Rohme, D.1
  • 31
    • 0020455613 scopus 로고
    • Werner's syndromes: A review of recent research with analysis of connective tissue metabolism, growth control of cultured cells, and chromosomal aberrations
    • Salk D. Werner's syndromes: a review of recent research with analysis of connective tissue metabolism, growth control of cultured cells, and chromosomal aberrations. Hum. Genet. 62:1982;1-5.
    • (1982) Hum. Genet. , vol.62 , pp. 1-5
    • Salk, D.1
  • 32
    • 0024439479 scopus 로고
    • The alpha-macroglobulin bait region. Sequence diversity and localization of cleavage sites for proteinases in five mammalian alpha-macroglobulins
    • Scottrup-Jensen L., Sand O., Kristensen L., Fey G.H. The alpha-macroglobulin bait region. Sequence diversity and localization of cleavage sites for proteinases in five mammalian alpha-macroglobulins. J. Biol. Chem. 264:1989;15781-15789.
    • (1989) J. Biol. Chem. , vol.264 , pp. 15781-15789
    • Scottrup-Jensen, L.1    Sand, O.2    Kristensen, L.3    Fey, G.H.4
  • 33
    • 0025052004 scopus 로고
    • Repression of c-fos transcription and an altered genetic program in senescent human fibroblasts
    • Seshadri T., Campisi J. Repression of c-fos transcription and an altered genetic program in senescent human fibroblasts. Science. 247:1990;205-209.
    • (1990) Science , vol.247 , pp. 205-209
    • Seshadri, T.1    Campisi, J.2
  • 34
    • 0034713329 scopus 로고    scopus 로고
    • Is β-galactosidase staining a maker of senescence in vitro and in vivo
    • Severino J., Allen R.G., Balin S., Balin A., Cristifalo V.J. Is β-galactosidase staining a maker of senescence in vitro and in vivo. Exp. Cell Res. 257:2000;162-171.
    • (2000) Exp. Cell Res. , vol.257 , pp. 162-171
    • Severino, J.1    Allen, R.G.2    Balin, S.3    Balin, A.4    Cristifalo, V.J.5
  • 35
    • 0024541932 scopus 로고
    • Regulation of collagenase and collagenase mRNA production in early and late-passage human diploid fibroblasts
    • Sottile J., Mann D.M., Diemer V., Millis A.J. Regulation of collagenase and collagenase mRNA production in early and late-passage human diploid fibroblasts. J. Cell Physiol. 138:1989;281-290.
    • (1989) J. Cell Physiol. , vol.138 , pp. 281-290
    • Sottile, J.1    Mann, D.M.2    Diemer, V.3    Millis, A.J.4
  • 36
    • 0028202945 scopus 로고
    • Cell aging of human diploid fibroblasts is associated with changes in responsiveness to epidermal growth factor and changes in HER-2 expression
    • Tang Z.Q., Zhang Z.Y., Zheng Y., Corbley M.J., Tong T.J. Cell aging of human diploid fibroblasts is associated with changes in responsiveness to epidermal growth factor and changes in HER-2 expression. Mech. Ageing Dev. 73:1994;57-67.
    • (1994) Mech. Ageing Dev. , vol.73 , pp. 57-67
    • Tang, Z.Q.1    Zhang, Z.Y.2    Zheng, Y.3    Corbley, M.J.4    Tong, T.J.5
  • 37
    • 0033732110 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes
    • Toussaint O., Medrano E.E., von Zglinicki T. Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes. Exp. Gerontol. 35:2000;927-945.
    • (2000) Exp. Gerontol. , vol.35 , pp. 927-945
    • Toussaint, O.1    Medrano, E.E.2    Von Zglinicki, T.3
  • 39
    • 0033016225 scopus 로고    scopus 로고
    • Effects of donor age on the expression of a marker of replicative senescence (EPC-1) in human dermal fibroblasts
    • Tresini M., Pignolo R.J., Allen R.G., Cristifalo V.J. Effects of donor age on the expression of a marker of replicative senescence (EPC-1) in human dermal fibroblasts. J. Cell Physiol. 179:1999;11-17.
    • (1999) J. Cell Physiol. , vol.179 , pp. 11-17
    • Tresini, M.1    Pignolo, R.J.2    Allen, R.G.3    Cristifalo, V.J.4
  • 40
    • 0020366769 scopus 로고
    • Age correlation of alpha-2-macroglobulin levels in healthy subjects
    • Wager V., Wagnerova M., Zvara K. Age correlation of alpha-2- macroglobulin levels in healthy subjects. Physiol. Bohemoslov. 31:1982;359-364.
    • (1982) Physiol. Bohemoslov. , vol.31 , pp. 359-364
    • Wager, V.1    Wagnerova, M.2    Zvara, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.