Anticoagulant fucoidan fractions from Fucus vesiculosus induce platelet activation in vitro

Thrombosis Research

Volumn 85, Issue 6, 1997, Pages 479-491

  Dürig, Jan ^a,c   Bruhn, Thomas ^a   Zurborn, Karl Heinz ^a   Gutensohn, Kai ^b   Bruhn, Hans D ^a   Béress, László ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c CHRISTIE HOSPITAL   (United Kingdom)

Author keywords

flow cytometry; fucoidan; molecular weight dependence; platelet activation

Indexed keywords

FUCOIDIN;

ANTICOAGULATION; ARTICLE; CONTROLLED STUDY; FIBRINOLYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION;

ALGAE, BROWN; ANTICOAGULANTS; ANTIGENS, CD; CELL ADHESION MOLECULES; FIBRINOLYSIS; FLOW CYTOMETRY; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; MALE; MOLECULAR WEIGHT; NEPHELOMETRY AND TURBIDIMETRY; P-SELECTIN; PLATELET ACTIVATION; PLATELET AGGREGATION; PLATELET FACTOR 4; PLATELET MEMBRANE GLYCOPROTEINS; POLYSACCHARIDES; STRUCTURE-ACTIVITY RELATIONSHIP; SULFATES; SULFURIC ACID ESTERS;

EID: 0342547019     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(97)00037-6     Document Type: Article

References (26)

1. SPRINGER, G.F., WURZEL, H.A., McNEAL, G.M. Jr., ANSELL, N.J., AND DOUGHTY, M.F. Isolation of anticoagulant fractions from crude fucoidan. Proc. Soc. Exp. Biol. Med. 94, 404-409, 1957.
2. GRAUFFEL, V., KLOAREG, B., MABEAU, S., DURAND, P., AND JOZEFONVICZ, J. New natural polysaccharides with potent antithrombic activity: fucans from brown algae. Biomaterials 10, 363-368, 1989.
3. CHURCH, F.C., MEADE, J.B., TREANOR, R.E., AND WHINNA, H.C. Antithrombin activity of fucoidan. J. Biol. Chem. 264, 3618-3623, 1989.
4. SOEDA, S., SAKAGUCHI, S., SHIMENO, H., AND NAGAMATSU, A. Fibrinolytic and anticoagulant activities of highly sulfated fucoidan. Biochem. Pharmacol. 43, 1853-1858, 1992.
5. SOEDA, S., OHMAGURI, Y., SHIMENO, H., AND NAGAMATSU, A. Preparation of oversulfated fucoidan fragments and evaluation of their antithrombotic activities. Thromb. Res. 72, 247-256, 1993.
6. McCAFFREY, T.A., FALCONE, BORTH, W, BRAYTON, C.F., AND WEKSLER, B.B. Fucoidan is a novel non-anticoagulant inhibitor of intimal hyperplasia. Biochem. Biophys. Res. Commun. 184, 773-781, 1992.
7. FUSTER, V., FALK, E., FALLON, J.T., BADIMON, L., CHESEBRO, J.H., AND BADIMON, J.J. The three processes leading to post PTCA restenosis: dependence on the lesion substrate. Thromb. Haemostasis. 74(1), 552-559, 1995.
8. MARUYAMA, H., NAKAJIMA, J., AND YAMAMOTO, I. A study on the anticoagulant and fibrinolytic activities of a crude fucoidan from the edible brown seaweed Laminaria religiosa, with special reference to its inhibitory effect on the growth of sarcoma-180 ascites cells subcutaneously implanted into mice. Kitasato Arch. of Exp. Med. 60 (3), 105-121, 1987.
9. BRUHN, T., DÜRIG, J., KRAISELBURD, E.N., DE CLERCQ, BRUHN, H.D., AND BÉRESS, L. Antiviral and anticoagulant activity of polysaccharides from marine brown algae. In: Biochemical Aspects of Marine Pharmacology. Eds.: Lazarovici, P., Spira, M.E., Zlotkin, E., Alaken Inc., Fort Collins, Colorado, 187-208, 1996.
10. FISCHER, A.M., MAUZAC, M., TAPON-BRETAUDIERE, J., And JOZEFOWICZ, J.: Anticoagulant activity of dextran derivatives.Part II: Mechanism of thrombin inactivation. Biomaterials 6, 198-202, 1985.
11. NAITO, K., AOKI, N. Assay of antiplasmin α 2-activity by means of a plasmin specific peptide substrate. Thromb. Res. 12, 1147-1156, 1978.
12. BORN, G.V.R. Quantitative investigations into the aggregation of blood platelets. J. Physiol. 162: 927-929, 1962.
13. PATANKAR, M.S., OEHNINGER, S., BARNETT, T., WILLIAMS, R.L., AND CLARK, G.F.: A revised structure for fucoidan may explain some of its biological activities. J. Biol.Chem. 268, 21770-21776, 1993.
14. SALZMANN, E.W., ROSENBERG, R.D., SMITH, M.H., LINDON, J.N., AND FAVREAU, L. Effect of heparin and heparin fractions on platelet aggregation. J. Clin. Invest. 65, 64-73, 1980.
15. METZELAAR, M.J., SIXMA, J.J., AND NIEUWENHUIS, H.K. Detection of platelet activation using specific monoclonal antibodies. Blood Cells 16, 85-96, 1990.
16. WUN, T., PAGLIERONI, T.G., AND LACHANT, N.A. Desmopressin stimulates expression of P-selectin on human platelets in vitro. J. Lab. Clin. Med. 126(4), 401-409, 1995.
17. OLEKSOWICZ, L., MROWIEC, Z., ISAACS, R., DUTCHER, I.P., AND PUSZKIN, E. Morphologic and ultrastructural evidence of interleukin-6 induced platelet activation. Am. J.. Hematol. 48(2), 92-99, 1995.
18. KANNAN, K., DIVERS, S.G., LURIE, A.A., CHERVENAK, R., FUKUDA, M., AND HOLCOMBE, R.F. Cell surface expression of lysosome-associated membrane protein-2 (lamp2) and CD63 as markers of in vivo platelet activation in malignancy. Eur. J. Haematol. 55(3), 145-151, 1995.
19. TSCHOEPE, D., SCHULTHEISS, H.P., KOLAROV, P., SCHWIPPERT, B., DANNEHL, K., NIEUWENHUIS, H.K., KEHREL, B., STRAUER, B., AND GRIES, F.A. Platelet membrane activation markers are predictive for increased risk of ischémie events after PTCA. Circulation 88(1), 37-42, 1993.
20. SHATTIL, S., CUNNINGHAM, M., AND HOXIE, J. A. Detection of activated platelets in whole blood using activation-dependent monoclonal antibodies and flow cytometry. Blood 70, 307-315, 1988.
21. LONGBIN, L., FREEDMAN, J., HORNSTEIN, A., FENTON, J.W., AND OFOSU, F.A. Thrombin binding to platelets and their activation in plasma. Br. J. Haematol. 88, 592-600, 1994.
22. CHONG, B.H. Heparin-induced thrombocytopenia. Blood Rev. 2, 108-114, 1988.
23. HORNE, M.K. AND CHAO, E.S. Heparin binding to resting and activated platelets. Blood 74, 238-243, 1989.
24. TARABOLETTI, G., ROBERTS, D., LIOTTA, A., AND GIAVAZZI, R. Platelet thrombospondin modulates endothelial cell adhesion, motility, and growth: a potential angiogenesis regulatory factor. J. Cell. Biol. 111, 765-772, 1990.
25. x, and sulfated glycans modulate this binding. Biochem. Biophys. Res. Commun. 181(3), 1223-1230, 1991.
26. GUTENSOHN, K., BRUHN, T., KÖSTER, R., DÜRIG, J., KAEHLER, J., BAU J., AND KUEHNL, P. Effects of fucoidan fractions on platelet antigens and proliferation of smooth muscle cells. Abstract, 27. Hämophilie-Symposium, Hamburg, 1996.