Conformational changes in dopamine transporter intracellular regions upon cocaine binding and dopamine translocation

Neurochemistry International

Volumn 73, Issue 1, 2014, Pages 4-15

  Dehnes, Yvette ^a,b   Shan, Jufang ^c   Beuming, Thijs ^c,d   Shi, Lei ^c   Weinstein, Harel ^c   Javitch, Jonathan A ^a,e  

^a Center for Molecular Recognition Columbia University College of Physicians and Surgaons ^*  (United States)

^b UNIVERSITY OF OSLO   (Norway)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d SCHRÖDINGER INC   (United States)

^e NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

Author keywords

Cocaine binding; Cysteine accessibility; Dopamine transport; Dopamine transporter (DAT); Molecular dynamics simulations

Indexed keywords

AMMONIUM DERIVATIVE; COCAINE; CYSTEINE; DOPAMINE; DOPAMINE TRANSPORTER; METHANETHIOSULFONATE ETHYL AMMONIUM; PHENYLALANINE; SERINE; SOLVENT; THIOL REAGENT; TYRAMINE; UNCLASSIFIED DRUG; ZINC; 2-CARBOMETHOXY-3-(3',4'-DICHLOROPHENYL)TROPANE; DOPAMINE UPTAKE INHIBITOR; TROPANE DERIVATIVE;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIGAND BINDING; MOLECULAR DYNAMICS; MOLECULAR MODEL; POINT MUTATION; PRIORITY JOURNAL; PROTEIN FUNCTION; STABLE EXPRESSION; SURFACE PROPERTY; WILD TYPE; CHEMISTRY; GENETICS; HEK293 CELL LINE; METABOLISM; MOLECULAR CLONING; PROTEIN CONFORMATION; PROTEIN TRANSPORT;

CLONING, MOLECULAR; COCAINE; CYSTEINE; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOPAMINE UPTAKE INHIBITORS; HEK293 CELLS; HUMANS; PROTEIN CONFORMATION; PROTEIN TRANSPORT; SULFHYDRYL REAGENTS; TROPANES; TYRAMINE; ZINC;

EID: 84902543559     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2014.02.003     Document Type: Article

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