Effects of traumatic brain injury and posttraumatic stress disorder on Alzheimer's disease in veterans, using the Alzheimer's Disease Neuroimaging Initiative

Alzheimer's and Dementia

Volumn 10, Issue 3 SUPPL., 2014, Pages

  Weiner, Michael W ^a,b,c   Veitch, Dallas P ^a   Hayes, Jacqueline ^a   Neylan, Thomas ^c   Grafman, Jordan ^d   Aisen, Paul S ^e   Petersen, Ronald C ^f   Jack, Clifford ^f   Jagust, William ^g   Trojanowski, John Q ^h   Shaw, Leslie M ^h   Saykin, Andrew J ⁱ   Green, Robert C ^j   Harvey, Danielle ^k   Toga, Arthur W ^l   Friedl, Karl E ^b   Pacifico, Anthony ^m   Sheline, Yvette ⁿ   Yaffe, Kristine ^b,c   Mohlenoff, Brian ^c  

^a SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d NORTHWESTERN UNIVERSITY   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f MAYO CLINIC   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h UNIVERSITY OF PENNSYLVANIA   (United States)

ⁱ INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^j BRIGHAM AND WOMEN S HOSPITAL   (United States)

^k UNIVERSITY OF CALIFORNIA   (United States)

^l UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^m U S ARMY MEDICAL RESEARCH AND MATERIEL COMMAND   (United States)

ⁿ WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

more..

Author keywords

Alzheimer's disease; Neuroimaging; Posttraumatic stress disorder; Traumatic brain injury; Veterans

Indexed keywords

APOLIPOPROTEIN E; BIOLOGICAL MARKER; FLORBETAPIR F 18;

ADULT; AGE; AGED; ALZHEIMER DISEASE; ARTICLE; CEREBROSPINAL FLUID; COGNITIVE RESERVE; CONTROLLED STUDY; EDUCATION; ETHNICITY; FOLLOW UP; GENDER; HUMAN; LUMBAR PUNCTURE; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; RISK FACTOR; SELF REPORT; TELEPHONE INTERVIEW; THERAPY EFFECT; TRAUMATIC BRAIN INJURY; VERY ELDERLY; VETERAN; BRAIN; BRAIN INJURIES; CLINICAL TRIAL; COHORT ANALYSIS; GOVERNMENT; METABOLISM; METHODOLOGY; MIDDLE AGED; MULTICENTER STUDY; PATHOLOGY; SOLDIER; STRESS DISORDERS, POST-TRAUMATIC; UNITED STATES;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BRAIN; BRAIN INJURIES; COHORT STUDIES; HUMANS; MIDDLE AGED; MILITARY PERSONNEL; RESEARCH DESIGN; RISK FACTORS; STRESS DISORDERS, POST-TRAUMATIC; UNITED STATES; UNITED STATES DEPARTMENT OF VETERANS AFFAIRS; VETERANS;

EID: 84902528704     PISSN: 15525260     EISSN: 15525279     Source Type: Journal    
DOI: 10.1016/j.jalz.2014.04.005     Document Type: Article

References (116)

1. S. Fleminger, D.L. Oliver, S. Lovestone, S. Rabe-Hesketh, and A. Giora Head injury as a risk factor for Alzheimer's disease: the evidence 10 years on; a partial replication J Neurol Neurosurg Psychiatry 74 7 2003 857 862
2. K. Yaffe, E. Vittinghoff, K. Lindquist, D. Barnes, K.E. Covinsky, and T. Neylan et al. Posttraumatic stress disorder and risk of dementia among US veterans Archives of general psychiatry 67 6 2010 608 613
3. S.U. Qureshi, T. Kimbrell, J.M. Pyne, K.M. Magruder, T.J. Hudson, and N.J. Petersen et al. Greater prevalence and incidence of dementia in older veterans with posttraumatic stress disorder J Am Geriatr Soc 58 9 2010 1627 1633
4. L.M. Shaw, H. Vanderstichele, M. Knapik-Czajka, M. Figurski, E. Coart, and K. Blennow et al. Qualification of the analytical and clinical performance of CSF biomarker analyses in ADNI Acta Neuropathol 121 5 2011 597 609
5. M.W. Weiner, D.P. Veitch, P.S. Aisen, L.A. Beckett, N.J. Cairns, and R.C. Green et al. The Alzheimer's Disease Neuroimaging Initiative: a review of papers published since its inception Alzheimers Dement 8 1 Suppl 2012 S1 68
6. V.E. Johnson, W. Stewart, and D.H. Smith Traumatic brain injury and amyloid-beta pathology: a link to Alzheimer's disease? Nat Rev Neurosci 11 5 2010 361 370
7. J.W. Williams, B.L. Plassman, J. Burke, and S. Benjamin Preventing Alzheimer's disease and cognitive decline Evid Rep Technol Assess (Full Rep) 193 2010 1 727
8. M. Bilbul, and H.M. Schipper Risk profiles of Alzheimer disease Can J Neurol Sci 38 4 2011 580 592
9. K.A. Jellinger Head injury and dementia Curr Opin Neurol 17 6 2004 719 723
10. T.C. Lye, and E.A. Shores Traumatic brain injury as a risk factor for Alzheimer's disease: a review Neuropsychol Rev 10 2 2000 115 129
11. C. Van Den Heuvel, E. Thornton, and R. Vink Traumatic brain injury and Alzheimer's disease: a review Progress in brain research 161 2007 303 316
12. J. Szczygielski, A. Mautes, W.I. Steudel, P. Falkai, T.A. Bayer, and O. Wirths Traumatic brain injury: cause or risk of Alzheimer's disease? A review of experimental studies Journal of neural transmission 112 11 2005 1547 1564
13. E.S. O'Meara, W.A. Kukull, L. Sheppard, J.D. Bowen, W.C. McCormick, and L. Teri et al. Head injury and risk of Alzheimer's disease by apolipoprotein E genotype Am J Epidemiol 146 5 1997 373 384
14. C.M. van Duijn, T.A. Tanja, R. Haaxma, W. Schulte, R.J. Saan, and A.J. Lameris et al. Head trauma and the risk of Alzheimer's disease AmJEpidemiol 135 7 1992 775 782
15. P.N. Nemetz, C. Leibson, J.M. Naessens, M. Beard, E. Kokmen, and J.F. Annegers et al. Traumatic brain injury and time to onset of Alzheimer's disease: a population-based study AmJEpidemiol 149 1 1999 32 40
16. K.M. Mehta, A. Ott, S. Kalmijn, A.J. Slooter, C.M. van Duijn, and A. Hofman et al. Head trauma and risk of dementia and Alzheimer's disease: The Rotterdam Study Neurology 53 9 1999 1959 1962
17. R. Mayeux, R. Ottman, M.X. Tang, L. Noboa-Bauza, K. Marder, and B. Gurland et al. Genetic susceptibility and head injury as risk factors for Alzheimer's disease among community-dwelling elderly persons and their first-degree relatives Ann Neurol 33 5 1993 494 501
18. R. Mayeux, R. Ottman, G. Maestre, C. Ngai, M.X. Tang, and H. Ginsberg et al. Synergistic effects of traumatic head injury and apolipoprotein-epsilon 4 in patients with Alzheimer's disease Neurology 45 3 Pt 1 1995 555 557
19. R. Katzman, D.R. Galasko, T. Saitoh, X. Chen, M.M. Pay, and A. Booth et al. Apolipoprotein-epsilon4 and head trauma: Synergistic or additive risks? Neurology 46 3 1996 889 891
20. B.D. Jordan, N.R. Relkin, L.D. Ravdin, A.R. Jacobs, A. Bennett, and S. Gandy Apolipoprotein E epsilon4 associated with chronic traumatic brain injury in boxing Jama 278 2 1997 136 140
21. G. Friedman, P. Froom, L. Sazbon, I. Grinblatt, M. Shochina, and J. Tsenter et al. Apolipoprotein E-epsilon4 genotype predicts a poor outcome in survivors of traumatic brain injury Neurology 52 2 1999 244 248
22. S.W. Lichtman, G. Seliger, B. Tycko, and K. Marder Apolipoprotein E and functional recovery from brain injury following postacute rehabilitation Neurology 55 10 2000 1536 1539
23. K.A. Jellinger, W. Paulus, C. Wrocklage, and I. Litvan Effects of closed traumatic brain injury and genetic factors on the development of Alzheimer's disease Eur J Neurol 8 6 2001 707 710
24. R. Diaz-Arrastia, Y. Gong, S. Fair, K.D. Scott, M.C. Garcia, and M.C. Carlile et al. Increased risk of late posttraumatic seizures associated with inheritance of APOE epsilon4 allele Arch Neurol 60 6 2003 818 822
25. N. Nathoo, R. Chetty, J.R. van Dellen, and G.H. Barnett Genetic vulnerability following traumatic brain injury: the role of apolipoprotein E Mol Pathol 56 3 2003 132 136
26. M. Ariza, R. Pueyo, M. Matarin Mdel, C. Junque, M. Mataro, and I. Clemente et al. Influence of APOE polymorphism on cognitive and behavioural outcome in moderate and severe traumatic brain injury J Neurol Neurosurg Psychiatry 77 10 2006 1191 1193
27. H. Houlden, and R. Greenwood Apolipoprotein E4 and traumatic brain injury J Neurol Neurosurg Psychiatry 77 10 2006 1106 1107
28. J.A. Nicoll, G.W. Roberts, and D.I. Graham Apolipoprotein E epsilon 4 allele is associated with deposition of amyloid beta-protein following head injury Nat Med 1 2 1995 135 137
29. G.W. Roberts, S.M. Gentleman, A. Lynch, and D.I. Graham beta A4 amyloid protein deposition in brain after head trauma Lancet 338 8780 1991 1422 1423
30. S.M. Gentleman, M.J. Nash, C.J. Sweeting, D.I. Graham, and G.W. Roberts Beta-amyloid precursor protein (beta APP) as a marker for axonal injury after head injury Neurosci Lett 160 2 1993 139 144
31. G.W. Roberts, S.M. Gentleman, A. Lynch, L. Murray, M. Landon, and D.I. Graham Beta amyloid protein deposition in the brain after severe head injury: implications for the pathogenesis of Alzheimer's disease J Neurol Neurosurg Psychiatry 57 4 1994 419 425
32. S.M. Gentleman, B.D. Greenberg, M.J. Savage, M. Noori, S.J. Newman, and G.W. Roberts et al. A beta 42 is the predominant form of amyloid beta-protein in the brains of short-term survivors of head injury Neuroreport 8 6 1997 1519 1522
33. K. Horsburgh, G.M. Cole, F. Yang, M.J. Savage, B.D. Greenberg, and S.M. Gentleman et al. beta-amyloid (Abeta)42(43), abeta42, abeta40 and apoE immunostaining of plaques in fatal head injury Neuropathol Appl Neurobiol 26 2 2000 124 132
34. D.H. Smith, X.H. Chen, A. Iwata, and D.I. Graham Amyloid beta accumulation in axons after traumatic brain injury in humans J Neurosurg 98 5 2003 1072 1077
35. K. Uryu, X.H. Chen, D. Martinez, K.D. Browne, V.E. Johnson, and D.I. Graham et al. Multiple proteins implicated in neurodegenerative diseases accumulate in axons after brain trauma in humans Exp Neurol 208 2 2007 185 192
36. X.H. Chen, V.E. Johnson, K. Uryu, J.Q. Trojanowski, and D.H. Smith A lack of amyloid beta plaques despite persistent accumulation of amyloid beta in axons of long-term survivors of traumatic brain injury Brain Pathol 19 2 2009 214 223
37. M.D. Ikonomovic, K. Uryu, E.E. Abrahamson, J.R. Ciallella, J.Q. Trojanowski, and V.M. Lee et al. Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury Exp Neurol 190 1 2004 192 203
38. S.T. DeKosky, E.E. Abrahamson, J.R. Ciallella, W.R. Paljug, S.R. Wisniewski, and R.S. Clark et al. Association of increased cortical soluble abeta42 levels with diffuse plaques after severe brain injury in humans Arch Neurol 64 4 2007 541 544
39. A.C. McKee, R.C. Cantu, C.J. Nowinski, E.T. Hedley-Whyte, B.E. Gavett, and A.E. Budson et al. Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury J Neuropathol Exp Neurol 68 7 2009 709 735
40. S. Shively, A.I. Scher, D.P. Perl, and R. Diaz-Arrastia Dementia Resulting From Traumatic Brain Injury: What Is the Pathology? Arch Neurol 2012 1 7
41. J.B. Toledo, S.E. Arnold, K. Raible, J. Brettschneider, S.X. Xie, and M. Grossman et al. Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer's Coordinating Centre Brain 136 Pt 9 2013 2697 2706
42. R. Yehuda, and J. Ledoux Response Variation following Trauma: A Translational Neuroscience Approach to Understanding PTSD Neuron 56 1 2007 19 32
43. M.E. McFall, P.W. Mackay, and D.M. Donovan Combat-related PTSD and psychosocial adjustment problems among substance abusing veterans The Journal of nervous and mental disease 179 1 1991 33 38
44. R.A. Kulka, W.E. Schlenger, J.A. Fairbank, R.L. Hough, B.K. Jordan, and C.R. Marmar et al. Trauma and the vietnam war generation 1990 Brunner/Mazel New York 1990
45. R.C. Kessler, A. Sonnega, E. Bromet, M. Hughes, and C.B. Nelson Posttraumatic stress disorder in the National Comorbidity Survey Archives of general psychiatry 52 12 1995 1048 1060
46. T.C. Smith, I.G. Jacobson, T.I. Hooper, C.A. Leardmann, E.J. Boyko, and B. Smith et al. Health impact of US military service in a large population-based military cohort: findings of the Millennium Cohort Study, 2001-2008 BMC Public Health 11 2011 69
47. L.K. Richardson, B.C. Frueh, and R. Acierno Prevalence estimates of combat-related post-traumatic stress disorder: critical review The Australian and New Zealand journal of psychiatry 44 1 2010 4 19
48. K.W. Samuelson, T.C. Neylan, T.J. Metzler, M. Lenoci, J. Rothlind, and C. Henn-Haase et al. Neuropsychological functioning in posttraumatic stress disorder and alcohol abuse Neuropsychology 20 6 2006 716 726
49. K.W. Samuelson, T.C. Neylan, M. Lenoci, T.J. Metzler, V. Cardenas, and M.W. Weiner et al. Longitudinal effects of PTSD on memory functioning J Int Neuropsychol Soc 15 6 2009 853 861
50. Schuff N, Marmar CR, Weiss DS, Neylan TC, Schoenfeld F, Fein G, et al. Reduced hippocampal volume and n-acetylaspartate in post traumatic stress disorder. The Annals of the New York Academy of Sciences. 1997;Supplement on Psychobiology of Posttraumatic Stress Disorder(821):516-20.
51. N. Schuff, T.C. Neylan, M.A. Lenoci, A.T. Du, D.S. Weiss, and C.R. Marmar et al. Decreased hippocampal N-acetylaspartate in the absence of atrophy in posttraumatic stress disorder Biol Psychiatry 50 12 2001 952 959
52. N. Schuff, T.C. Neylan, S. Fox-Bosetti, M. Lenoci, K.W. Samuelson, and C. Studholme et al. Abnormal N-acetylaspartate in hippocampus and anterior cingulate in posttraumatic stress disorder Psychiatry Res 162 2 2008 147 157
53. Z. Wang, T.C. Neylan, S.G. Mueller, M. Lenoci, D. Truran, and C.R. Marmar et al. Magnetic resonance imaging of hippocampal subfields in posttraumatic stress disorder Arch Gen Psychiatry 67 3 2010 296 303
54. B.A. Apfel, J. Ross, J. Hlavin, D.J. Meyerhoff, T.J. Metzler, and C.R. Marmar et al. Hippocampal volume differences in Gulf War veterans with current versus lifetime posttraumatic stress disorder symptoms Biol Psychiatry 69 6 2011 541 548
55. S.H. Woodward, M. Schaer, D.G. Kaloupek, L. Cediel, and S. Eliez Smaller global and regional cortical volume in combat-related posttraumatic stress disorder Arch Gen Psychiatry 66 12 2009 1373 1382
56. N. Ahmadi, F. Hajsadeghi, H.B. Mirshkarlo, M. Budoff, R. Yehuda, and R. Ebrahimi Post-traumatic Stress Disorder, Coronary Atherosclerosis, and Mortality Am J Cardiol 108 1 2011 29 33
57. M.L. O'Donnell, M. Creamer, and P. Pattison Posttraumatic stress disorder and depression following trauma: understanding comorbidity The American journal of psychiatry 161 8 2004 1390 1396
58. A.Y. Shalev, S. Freedman, T. Peri, D. Brandes, T. Sahar, and S.P. Orr et al. Prospective study of posttraumatic stress disorder and depression following trauma The American journal of psychiatry 155 5 1998 630 637
59. S.G. Mueller, M.W. Weiner, L.J. Thal, R.C. Petersen, C. Jack, and W. Jagust et al. The Alzheimer's disease neuroimaging initiative Neuroimaging Clin N Am 15 4 2005 869 877 xi-xii
60. M.W. Weiner, P.S. Aisen, C.R. Jack Jr., W.J. Jagust, J.Q. Trojanowski, and L. Shaw et al. The Alzheimer's disease neuroimaging initiative: progress report and future plans Alzheimers Dement 6 3 2010 202 211.e7
61. S. Salloway New lessons from the Alzheimer's Disease Neuroimaging Initiative Arch Neurol 68 1 2011 19 21
62. R.C. Petersen, P.S. Aisen, L.A. Beckett, M.C. Donohue, A.C. Gamst, and D.J. Harvey et al. Alzheimer's Disease Neuroimaging Initiative (ADNI): clinical characterization Neurology 74 3 2010 201 209
63. P.S. Aisen, R.C. Petersen, M.C. Donohue, A. Gamst, R. Raman, and R.G. Thomas et al. Clinical Core of the Alzheimer's Disease Neuroimaging Initiative: progress and plans Alzheimers Dement 6 3 2010 239 246
64. C.R. Jack Jr., M.A. Bernstein, B.J. Borowski, J.L. Gunter, N.C. Fox, and P.M. Thompson et al. Update on the magnetic resonance imaging core of the Alzheimer's disease neuroimaging initiative Alzheimers Dement 6 3 2010 212 220
65. W.J. Jagust, D. Bandy, K. Chen, N.L. Foster, S.M. Landau, and C.A. Mathis et al. The Alzheimer's Disease Neuroimaging Initiative positron emission tomography core Alzheimers Dement 6 3 2010 221 229
66. L.M. Shaw PENN biomarker core of the Alzheimer's disease Neuroimaging Initiative Neurosignals 16 1 2008 19 23
67. A.J. Saykin, L. Shen, T.M. Foroud, S.G. Potkin, S. Swaminathan, and S. Kim et al. Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans Alzheimers Dement 6 3 2010 265 273
68. L. Shen, S. Kim, S.L. Risacher, K. Nho, S. Swaminathan, and J.D. West et al. Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort Neuroimage 53 3 2010 1051 1063
69. J. Lister-James, M.J. Pontecorvo, C. Clark, A.D. Joshi, M.A. Mintun, and W. Zhang et al. Florbetapir f-18: a histopathologically validated Beta-amyloid positron emission tomography imaging agent Semin Nucl Med 41 4 2011 300 304
70. C.M. Clark, J.A. Schneider, B.J. Bedell, T.G. Beach, W.B. Bilker, and M.A. Mintun et al. Use of florbetapir-PET for imaging beta-amyloid pathology JAMA 305 3 2011 275 283
71. N. Okamura, and K. Yanai Florbetapir (18F), a PET imaging agent that binds to amyloid plaques for the potential detection of Alzheimer's disease IDrugs 13 12 2010 890 899
72. D.F. Wong, P.B. Rosenberg, Y. Zhou, A. Kumar, V. Raymont, and H.T. Ravert et al. In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapir [corrected] F 18) J Nucl Med 51 6 2010 913 920
73. A.J. Furst, G.D. Rabinovici, A.H. Rostomian, T. Steed, A. Alkalay, and C. Racine et al. Cognition, glucose metabolism and amyloid burden in Alzheimer's disease Neurobiol Aging 33 2 2012 215 225
74. A. Forsberg, H. Engler, O. Almkvist, G. Blomquist, G. Hagman, and A. Wall et al. PET imaging of amyloid deposition in patients with mild cognitive impairment Neurobiol Aging 29 10 2008 1456 1465
75. D.A. Wolk, J.C. Price, J.A. Saxton, B.E. Snitz, J.A. James, and O.L. Lopez et al. Amyloid imaging in mild cognitive impairment subtypes Ann Neurol 65 5 2009 557 568
76. W.J. Jagust, S.M. Landau, L.M. Shaw, J.Q. Trojanowski, R.A. Koeppe, and E.M. Reiman et al. Relationships between biomarkers in aging and dementia Neurology 73 15 2009 1193 1199
77. G. De Meyer, F. Shapiro, H. Vanderstichele, E. Vanmechelen, S. Engelborghs, and P.P. De Deyn et al. Diagnosis-Independent Alzheimer Disease Biomarker Signature in Cognitively Normal Elderly People Arch Neurol 67 8 2010 949 956
78. C.C. Rowe, K.A. Ellis, M. Rimajova, P. Bourgeat, K.E. Pike, and G. Jones et al. Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging Neurobiol Aging 31 8 2010 1275 1283
79. M.F. Kraus, T. Susmaras, B.P. Caughlin, C.J. Walker, J.A. Sweeney, and D.M. Little White matter integrity and cognition in chronic traumatic brain injury: a diffusion tensor imaging study Brain 130 Pt 10 2007 2508 2519
80. S.N. Niogi, P. Mukherjee, J. Ghajar, C. Johnson, R.A. Kolster, and R. Sarkar et al. Extent of microstructural white matter injury in postconcussive syndrome correlates with impaired cognitive reaction time: a 3T diffusion tensor imaging study of mild traumatic brain injury AJNR Am J Neuroradiol 29 5 2008 967 973
81. S.N. Niogi, P. Mukherjee, J. Ghajar, C.E. Johnson, R. Kolster, and H. Lee et al. Structural dissociation of attentional control and memory in adults with and without mild traumatic brain injury Brain 131 Pt 12 2008 3209 3221
82. D.D. Blake, F.W. Weathers, L.M. Nagy, D.G. Kaloupek, F.D. Gusman, and D.S. Charney et al. The development of a Clinician-Administered PTSD Scale J Trauma Stress 8 1 1995 75 90
83. R.L. Spitzer, J.B. Williams, M. Gibbon, and M.B. First The Structured Clinical Interview for DSM-III-R (SCID). I: History, rationale, and description ArchGeneral Psychiatry 49 1992 624 629
84. A.T. McLellan, L. Luborsky, G.E. Woody, and C.P. O'Brien An improved diagnostic evaluation instrument for substance abuse patients. The Addiction Severity Index J Nerv Ment Dis 168 1 1980 26 33
85. A.T. McLellan, H. Kushner, D. Metzger, R. Peters, I. Smith, and G. Grissom et al. The Fifth Edition of the Addiction Severity Index J Subst Abuse Treat 9 3 1992 199 213
86. L. Derogatis, and L. Lazarus SCL-90-R, Brief symptom inventory, and matching clinical rating scales M.E. Maruish, The use of psychological testing for treatment planning and outcome assessment 1994 Lawrence Erlbaum Associates, Inc. Hillsdale, NJ 217 248
87. D.J. Buysse, C.F. Reynolds 3rd, T.H. Monk, S.R. Berman, and D.J. Kupfer The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research Psychiatry Res 28 2 1989 193 213
88. C.A. Schoenborn, P.F. Adams, and J.S. Schiller Summary health statistics for the U.S. population: National Health Interview Survey 2002 Vital Health Stat 10 214 2003 1 83
89. Institute NC. Dictionary of cancer terms: Pack year. 2011 [5/16/201i]. Available from: http://www.cancer.gov/dictionary/?CdrID=306510.
90. J.E. Ware, M. Kosinski, and S.D. Keller A 12-Item Short-Form Health Survey - Construction of Scales and Preliminary Tests of Reliability and Validity Medical Care 34 3 1996 220 233
91. T.M. Keane, J.A. Fairbank, J.M. Caddell, R.T. Zimering, K.L. Taylor, and C. Mora Clinical evaluation of a measure to assess combat exposure J of Consulting and Clinical Psychology 1 1989 53 55
92. J. Grafman, B.S. Jonas, A. Martin, A.M. Salazar, H. Weingartner, and C. Ludlow et al. Intellectual function following penetrating head injury in Vietnam veterans. Brain a journal of neurology 111 Pt 1 1988 169 184
93. Grafman J, Salazar A, Weingartner H, Vance S, Amin D. The relationship of brain-tissue loss volume and lesion location to cognitive deficit. The Journal of neuroscience: the official journal of the Society for Neuroscience. 1986;6(2):301-7.
94. Z.S. Nasreddine, I. Collin, H. Chertkow, N. Phillips, H. Bergman, and V. Whitehead Sensitivity and Specificity of The Montreal Cognitive Assessment (MOCA) for Detection of Mild Cognitive Deficits Can J Neurol Sci 30 2 2003 30
95. S.T. Farias, D. Mungas, B.R. Reed, D. Cahn-Weiner, W. Jagust, and K. Baynes et al. The measurement of everyday cognition (ECog): scale development and psychometric properties Neuropsychology 22 4 2008 531 544
96. W.G. Rosen, R.C. Mohs, and K.L. Davis A new rating scale for Alzheimer's disease American Journal of Psychiatry 141 11 1984 1356 1364
97. D. Wechsler Wechsler Memory Scale-Revised 1987 The Psychological Corporation San Antonio, TX
98. E. Kaplan, H. Goodglass, and S. Weintraub Boston Naming Test 1983 Lea & Febiger Philadelphia
99. N. Butters, E. Granholm, D.P. Salmon, I. Grant, and J. Wolfe Episodic and semantic memory: a comparison of amnesic and demented patients J Clin Exp Neuropsychol 9 5 1987 479 497
100. H.E. Nelson, and A. O'Connell Dementia: the estimation of premorbid intelligence levels using the New Adult Reading Test Cortex 14 1978 234 244
101. A. Rey L'examen clinique en psychologie 1964 Presses Universitaires de France Paris
102. R.M. Reitan Validity of the Trail Making test as an indicator of organic brain damage Percept Mot Skills 8 1957 271 276
103. E.A. Gaudino, M.W. Geisler, and N.K. Squires Construct validity in the Trail Making Test: what makes Part B harder? Journal of clinical and experimental neuropsychology 17 4 1995 529 535
104. J.D. Corrigan, and N.S. Hinkeldey Relationships between parts A and B of the Trail Making Test Journal of clinical psychology 43 4 1987 402 409
105. L. Berg Clinical Dementia Rating (CDR) Psychopharmacol Bull 24 4 1988 637 639
106. R.I. Pfeffer, T.T. Kurosaki, C.H. Harrah Jr., J.M. Chance, and S. Filos Measurement of functional activities in older adults in the community J Gerontol 37 3 1982 323 329
107. D.I. Kaufer, J.L. Cummings, P. Ketchel, V. Smith, A. MacMillan, and T. Shelley et al. Validation of the NPI-Q, a brief clinical form of the Neuropsychiatric Inventory J Neuropsychiatry Clin Neurosci 12 2 2000 233 239
108. Sheikh JI, Yesavage J. Geriatric Depression Scale (GDS): Recent evidence and development of a shorter version. Clinical Gerontology: A Guide to Assessment and Intervention New York: The Haworth Press; Editor T.L. Brink. 1986. p. 165-73.
109. S.V. Subramanian, J.T. Chen, D.H. Rehkopf, P.D. Waterman, and N. Krieger Comparing individual- and area-based socioeconomic measures for the surveillance of health disparities: A multilevel analysis of Massachusetts births, 1989-1991 AmJEpidemiol 164 9 2006 823 834
110. A. Olsson, H. Vanderstichele, N. Andreasen, G. De Meyer, A. Wallin, and B. Holmberg et al. Simultaneous measurement of beta-amyloid(1-42), total tau, and phosphorylated tau (Thr181) in cerebrospinal fluid by the xMAP technology Clin Chem 51 2 2005 336 345
111. L.M. Shaw, H. Vanderstichele, M. Knapik-Czajka, C.M. Clark, P.S. Aisen, and R.C. Petersen et al. Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects Ann Neurol 65 4 2009 403 413
112. N. Mattsson, U. Andreasson, S. Persson, H. Arai, S.D. Batish, and S. Bernardini et al. The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers Alzheimers Dement 7 4 2011 386 395.e6
113. http://www.adni-info.org/Scientists/ADNIStudyProcedures.aspx.
114. B. Fischl, D.H. Salat, E. Busa, M. Albert, M. Dieterich, and C. Haselgrove et al. Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain Neuron 33 3 2002 341 355
115. J.D. Elashoff nQuery Advisor® Version 4.0 Users's Guide 2000 Statistical Solutions Los Angeles, CA
116. https://ida.loni.ucla.edu.