Reduced hippocampal volume and N-acetyl aspartate in posttraumatic stress disorder

Annals of the New York Academy of Sciences

Volumn 821, Issue , 1997, Pages 516-520

  Schuff, N ^a   Marmar, C R ^a   Weiss, D S ^a   Neylan, T C ^a   Schoenfeld, F ^a   Fein, G ^a   Weiner, M W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

N ACETYLASPARTIC ACID;

ADULT; ALCOHOL ABUSE; ALZHEIMER DISEASE; BRAIN ATROPHY; CELL DENSITY; CELL LOSS; CELL VIABILITY; CHILD ABUSE; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; DIAGNOSTIC VALUE; FEMALE; GLIA CELL; HIPPOCAMPUS; HUMAN; MALE; MORPHOLOGY; NERVE CELL; NERVE DEGENERATION; NUCLEAR MAGNETIC RESONANCE IMAGING; POSTTRAUMATIC STRESS DISORDER; PROGNOSIS; PROTON NUCLEAR MAGNETIC RESONANCE; TEMPORAL LOBE EPILEPSY;

EID: 0030837781     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1997.tb48319.x     Document Type: Conference Paper

References (16)

1. BREMNER, J. D., P. RANDALL, T. M. SCOTT, R. A. BRONEN, J. P. & SEIBYL, S. M. SOUTHWICK, R. C. DELANEY, G. MCCARTHY, D. S. CHARNEY & R. B. INNIS. 1995. MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder. Am. J. Psychiatry 152: 973-981.
2. GURVITS, T. V., M. E. SHENTON, H. HOKAMA, H. OHTA, N. B. LASKO, S. P. ORR, R. KIKINIS, F. A. JOLESZ, R. W. MCCARLEY & R. K. PITMAN. 1996. Magnetic resonance imaging study of hippocampal volume in chronic, combat-related post-traumatic stress disorder. Biol. Psychiatry 40: 1091-1099.
3. BREMNER, J. D., P. RANDALL E. VERMETTEN, L. STAIB, R. A. BRONEN, C. MAZURE, S. CAPELLI, G. MCCARTHY, R. B. INNIS & D. S. CHARNEY. 1997. MRI-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse-A preliminary report. Biol. Psychiatry 41: 23-32.
4. STEIN, M. B., C. KOVEROLA, C. HANNA, M. G. TORCHIA, V. VAERUM & B. MCCLARTY. 1996. Memory and hippocampal volume in adult female survivors of childhood sexual abuse. Submitted.
5. FONTANA, A., R. ROSENHECK & H. SPENCER. 1990. The first progress report on the Department of Veterans Affairs PTSD clinical teams program. West Haven, CT. Northeast Program Evaluation Center.
6. SULLIVAN, E. V., L. MARSH, D. H. MATHALON, K. O. LIM & A. PFEFFERBAUM. 1995. Anterior hippocampal volume deficits in nonamnesic, aging chronic alcoholics. Alcohol Clin. Exp. Res. 19: 110-122.
7. 1H-NMR spectroscopic studies of brain. Neurosci. Biobehav. Rev. 13: 23-31.
8. 1H MRSI shows bilateral metabolite changes in unilateral TLE patients with and without hippocampal atrophy. Proc. Soc. Magnetic Resonance 144: (Abstr.).
9. 1H MR spectroscopic imaging in the study of Alzheimer's disease, subcortical ischemic vascular dementia and elderly controls. Radiology 198: 537-545; Schuff, N. et al. Unpublished results.
10. SPITZER, R. L., J. B. WILLIAMS, M. GIBBON & M. B. FIRST. 1992. The Structured Clinical Interview for DSM-III-R (SCID). I. History, rationale, and description. Arch. Gen. Psychiatry 49: 624-629.
11. WATSON, C., F. ANDERMANN, P. GLOOR, M. JONES-GOTMAN, T. PETERS, A. EVANS, A. OLIVIER, D. MELANSON & G. LEROUX. 1992. Anatomic basis of amygdaloid and hippocampal volume measurement by magnetic resonance imaging. Neurology, 42: 1743-1750.
12. 1H MR spectroscopic imaging study. Proc. Int. Soc. Magnetic Resonance Med. 4: 308 (Abstr.).
13. YEHUDA, R., S. M. SOUTHWICK, J. H. KRYSTAL, D. BREMNER, D. S. CHARNEY & J. W. MASON. 1993. Enhanced suppression of cortisol following dexamethasone administration in posttraumatic stress disorder. Am. J. Psychiatry 150: 83-86.
14. YEHUDA, R., D. BOISONEAU, M. T. LOWY & E. L. GILLER, JR. 1995. Dose-response changes in plasma cortisol and lymphocyte glucocorticoid receptors following dexamethasone administration in combat veterans with and without posttraumatic stress disorder. Arch. Gen. Psychiatry 52: 583-593.
15. W. A. FALLS & M. DAVIS. 1995. Behavioral and physiological analysis of fear inhibition: Extinction and conditioned inhibition. In Neurobiological and Clinical Consequences of Stress: From Normal Adaptation to Post-traumatic Stress Disorder. M. J. Friedman, D. S. Charney & A. Y. Deutch, Eds.: 177. Lippincott-Raven. Philadelphia.
16. SCHMALTZ, L. W. & J. THEIOS. 1972. Acquisition and extinction of a classically conditioned response in hippocampectomized rabbits (Oryctolagus cuniculus). J. Comp. Physiol. Psychol. 79: 328-333.