7-MEOTA-donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies

European Journal of Medicinal Chemistry

Volumn 82, Issue , 2014, Pages 426-438

  Korabecny, Jan ^a,b   Dolezal, Rafael ^a   Cabelova, Pavla ^d   Horova, Anna ^b   Hruba, Eva ^d   Ricny, Jan ^e   Sedlacek, Lukas ^g   Nepovimova, Eugenie ^a,b   Spilovska, Katarina ^a,b   Andrs, Martin ^a,b   Musilek, Kamil ^f   Opletalova, Veronika ^d   Sepsova, Vendula ^a,b   Ripova, Daniela ^e   Kuca, Kamil ^a,b,c,f  

^a UNIVERSITY HOSPITAL HRADEC KRALOVE   (Czech Republic)

^b UNIVERSITY OF DEFENCE   (Czech Republic)

^c UNIVERSITY OF DEFENCE   (Czech Republic)

^d Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^e NATIONAL INSTITUTE OF MENTAL HEALTH   (Czech Republic)

^f UNIVERSITY OF HRADEC KRALOVE   (Czech Republic)

^g CHARLES UNIVERSITY   (Czech Republic)

Author keywords

7 MEOTA; AChE BChE inhibitors; Alzheimer's disease; Molecular modeling; QSAR; Tacrine

Indexed keywords

4 [[4 [2 [(7 METHOXY 1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]ETHYL]PIPERAZIN 1 YL]METHYL]BENZONITRILE TRIHYDROCHLORIDE; 7 METHOXY 1,2,3,4 TETRAHYDROACRIDIN 9(10H) ONE; 7 METHOXY N [2 (PIPERAZIN 1 YL)ETHYL] 1,2,3,4 TETRAHYDROACRIDIN 9 AMINE; 7 METHOXY N [2 [4 (2 PHENYLETHYL)PIPERAZIN 1 YL]ETHYL] 1,2,3,4 TETRAHYDROACRIDIN 9 AMINE TRIHYDROCHLORIDE; 7 METHOXY N [2 [4 (3 PHENYLPROPYL)PIPERAZIN 1 YL]ETHYL] 1,2,3,4 TETRAHYDROACRIDIN 9 AMINE TRIHYDROCHLORIDE; 7 METHOXY N [2 [4 (5 PHENYLPENTYL)PIPERAZIN 1 YL]ETHYL] 1,2,3,4 TETRAHYDROACRIDIN 9 AMINE TRIHYDROCHLORIDE; 7 METHOXY N [2 [4 (NAPHTHALEN 1 YL)ETHYL)PIPERAZIN 1 YL]ETHYL] 1,2,3,4 TETRAHYDROACRIDIN 9 AMINE TRIHYDROCHLORIDE; 7 METHOXY N [2 [4 (NAPHTHALEN 1 YLMETHYL)PIPERAZIN 1 YL]ETHYL] 1,2,3,4 TETRAHYDROACRIDIN 9 AMINE TRIHYDROCHLORIDE; 7 METHOXY N [2 [4 (NAPHTHALEN 2 YLMETHYL)PIPERAZIN 1 YL]ETHYL] 1,2,3,4 TETRAHYDROACRIDIN 9 AMINE TRIHYDROCHLORIDE; 7 METHOXY N [2 [4 (PROP 2 YN 1 YL)PIPERAZIN 1 YL]ETHYL] 1,2,3,4 TETRAHYDROACRIDIN 9 AMINE TRIHYDROCHLORIDE; 7 METHOXY N [2 [4 [(2 METHYLPHENYL)METHYL]PIPERAZIN 1 YL]ETHYL] 1,2,3,4 TETRAHYDROACRIDIN 9 AMINE TRIHYDROCHLORIDE; 7 METHOXY N [2 [4 [(4 METHYLPHENYL)METHYL]PIPERAZIN 1 YL]ETHYL] 1,2,3,4 TETRAHYDROACRIDIN 9 AMINE TRIHYDROCHLORIDE; 7 METHOXY N [2 [4 [(4 NITROPHENYL)METHYL]PIPERAZIN 1 YL]ETHYL] 1,2,3,4 TETRAHYDROACRIDIN 9 AMINE TRIHYDROCHLORIDE; 7 METHOXY N [2 [4 [[4 (METHYLSULFANYL)PHENYL]METHYL]PIPERAZIN 1 YL]ETHYL] 1,2,3,4 TETRAHYDROACRIDIN 9 AMINE TRIHYDROCHLORIDE; 7 METHOXY N [2 [4 [[4 (PROPAN 2 YL)PHENYL]METHYL]PIPERAZIN 1 YL]ETHYL] 1,2,3,4 TETRAHYDROACRIDIN 9 AMINE TRIHYDROCHLORIDE; 7 METHOXY N [2 [4 [[4 (TRIFLUOROMETHYL)PHENYL]METHYL]PIPERAZIN 1 YL]ETHYL] 1,2,3,4 TETRAHYDROACRIDIN 9 AMINE TRIHYDROCHLORIDE; 7 METHOXY N [2 [4[(3 METHYLPHENYL)METHYL]PIPERAZIN] 1 YL] 1,2,3,4 TETRAHYDROACRIDIN 9 AMINE TRIHYDROCHLORIDE; 7 METHOXYTACRINE; 9 CHLORO 7 METHOXY 1,2,3,4 TETRAHYDROACRIDINE; ACETYLCHOLINESTERASE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; DONEPEZIL; METHYL 4 [[4 [2 [(7 METHOXY 1,2,3,4 TETRAHYDROACRIDIN 9 YL) AMINO]ETHYL]PIPERAZIN 1 YL]METHYLBENZOATE TRIHYDROCHLORIDE; N [2 (4 BENZYLPIPERAZIN 1 YL)ETHYL] 7 METHOXY 1,2,3,4 TETRAHYDROACRIDIN 9 AMINE TRIHYDROCHLORIDE; N [2 [4 (CYCLOHEXYLMETHYL)PIPERAZIN 1 YL]ETHYL] 7 METHOXY 1,2,3,4 TETRAHYDROACRIDIN 9 AMINE TRIHYDROCHLORIDE; N [2 [4 [(2 BROMOPHENYL)METHYL]PIPERAZIN 1 YL]ETHYL] 7 METHOXY 1,2,3,4 TETRAHYDROACRIDIN 9 AMINE TRIHYDROCHLORIDE; N [2 [4 [(3 BROMOPHENYL)METHYL]PIPERAZIN 1 YL]ETHYL] 7 METHOXY 1,2,3,4 TETRAHYDROACRIDIN 9 AMINE TRIHYDROCHLORIDE; N [2 [4 [(3,5 DIMETHYLPHENYL)METHYL]PIPERAZIN 1 YL]ETHYL] 7 METHOXY 1,2,3,4 TETRAHYDROACRIDIN 9 AMINE TRIHYDROCHLORIDE; N [2 [4 [(4 BROMOPHENYL)METHYL]PIPERAZIN 1 YL]ETHYL] 7 METHOXY 1,2,3,4 TETRAHYDROACRIDIN 9 AMINE TRIHYDROCHLORIDE; UNCLASSIFIED DRUG; INDAN DERIVATIVE; PIPERIDINE DERIVATIVE; RECOMBINANT PROTEIN; TACRINE;

ANIMAL TISSUE; ARTICLE; BINDING SITE; BIOLOGICAL ACTIVITY; CATALYTIC ANIONIC SITE; CONTROLLED STUDY; DRUG SYNTHESIS; ELECTROPHORUS; ENZYME INHIBITION; ENZYME KINETICS; EQUIDAE; HUMAN; IC 50; IN VITRO STUDY; MALE; MOLECULAR MODEL; NONHUMAN; PERIPHERAL ANIONIC SITE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; HORSE; METABOLISM; SYNTHESIS;

ACETYLCHOLINESTERASE; ANIMALS; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORUS; HORSES; HUMANS; INDANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PIPERIDINES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECOMBINANT PROTEINS; TACRINE;

EID: 84902505998     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.05.066     Document Type: Article

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