Disruption of interleukin-1β autocrine signaling rescues complex I activity and improves ROS levels in immortalized epithelial cells with impaired Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) function

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Clauzure, Mariángeles ^a   Valdivieso, Angel G ^a   Massip Copiz, María M ^a   Schulman, Gustavo ^a   Teiber, María Luz ^a   Santa Coloma, Tomás A ^a  

^a PONTIFICIA UNIVERSIDAD CATÓLICA ARGENTINA   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BLOCKING ANTIBODY; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; I KAPPA B KINASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SHORT HAIRPIN RNA; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; ANTIBODY; CULTURE MEDIUM; IMIDAZOLE DERIVATIVE; INTERLEUKIN 1 RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE P38; PYRIDINE DERIVATIVE; SMALL INTERFERING RNA; UBIQUINOL CYTOCHROME C REDUCTASE;

ARTICLE; AUTOCRINE EFFECT; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVITY; ENZYME INHIBITION; EPITHELIUM CELL; HUMAN; HUMAN CELL; IMMORTALIZED CELL LINE; MITOCHONDRION; MOLECULAR PROBE; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; ANTAGONISTS AND INHIBITORS; CACO 2 CELL LINE; CELL LINE; CULTURE MEDIUM; CYTOLOGY; DRUG EFFECTS; GENETICS; IMMUNOLOGY; METABOLISM; PHARMACOLOGY; RNA INTERFERENCE; SECRETION (PROCESS);

ANTIBODIES; AUTOCRINE COMMUNICATION; CACO-2 CELLS; CELL LINE; CULTURE MEDIA, SERUM-FREE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; ELECTRON TRANSPORT COMPLEX I; ELECTRON TRANSPORT COMPLEX III; EPITHELIAL CELLS; HUMANS; IMIDAZOLES; INTERLEUKIN-1BETA; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOCHONDRIA; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES; REACTIVE OXYGEN SPECIES; RECEPTORS, INTERLEUKIN-1; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 84902491093     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0099257     Document Type: Article

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