The expression of the mitochondrial gene MT-ND4 is downregulated in cystic fibrosis

Biochemical and Biophysical Research Communications

Volumn 356, Issue 3, 2007, Pages 805-809

  Valdivieso, Ángel G ^a,b,c   Marcucci, Florencia ^a,b,c   Taminelli, Guillermo ^a,b,c   Guerrico, Anatilde González ^a,b,c   Álvarez, Sergio ^a,b,c   Teiber, María Luz ^a,b,c   Dankert, Marcelo A ^a,b,c   Santa Coloma, Tomás A ^a,b,c  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b FUNDACIÓN INSTITUTO LELOIR   (Argentina)

^c PONTIFICIA UNIVERSIDAD CATÓLICA ARGENTINA   (Argentina)

Author keywords

CFDE; CFTR; CFTR(inh) 172; Cystic fibrosis; Glibenclamide; Mitochondria; Mitochondrial expressed genes; MT ND4

Indexed keywords

GLIBENCLAMIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); TRANSMEMBRANE CONDUCTANCE REGULATOR;

ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN SITU HYBRIDIZATION; MITOCHONDRIAL GENE; MT ND4 GENE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

BASE SEQUENCE; BENZOIC ACIDS; CELL LINE; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DOWN-REGULATION; GENE EXPRESSION; GLYBURIDE; HUMANS; IN SITU HYBRIDIZATION; LUNG; MOLECULAR SEQUENCE DATA; NADH DEHYDROGENASE; THIAZOLIDINES;

EID: 33947644153     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.03.057     Document Type: Article

References (18)

1. Riordan J.R., Rommens J.M., Kerem B., Alon N., Rozmahel R., Grzelczak Z., Zielenski J., Lok S., Plavsic N., Chou J.L., Drum M.L., Iannuzzi M.C., Collins F., and Tsui L.-C. Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science 245 (1989) 1066-1073
2. Liang P., and Pardee A.B. Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science 257 (1992) 967-971
3. Gonzalez-Guerrico A.M., Cafferata E.G., Radrizzani M., Marcucci F., Gruenert D., Pivetta O.H., Favaloro R.R., Laguens R., Perrone S.V., Gallo G.C., and Santa-Coloma T.A. Tyrosine kinase c-Src constitutes a bridge between cystic fibrosis transmembrane regulator channel failure and MUC1 overexpression in cystic fibrosis. J. Biol. Chem. 277 (2002) 17239-17247
4. Lei D.C., Kunzelmann K., Koslowsky T., Yezzi M.J., Escobar L.C., Xu Z., Ellison A.R., Rommens J.M., Tsui L.C., Tykocinski M., and Gruenert D.C. Episomal expression of wild-type CFTR corrects cAMP-dependent chloride transport in respiratory epithelial cells. Gene Ther. 3 (1996) 427-436
5. Hirst J., Carroll J., Fearnley I.M., Shannon R.J., and Walker J.E. The nuclear encoded subunits of complex I from bovine heart mitochondria. Biochim. Biophys. Acta. 1604 (2003) 135-150
6. Liang P., Averboukh L., and Pardee A.B. Distribution and cloning of eukaryotic mRNAs by means of differential display: refinements and optimization. Nucleic Acids Res. 21 (1993) 3269-3275
7. Cafferata E.G., Gonzalez-Guerrico A.M., Pivetta O.H., and Santa-Coloma T.A. Identification by differential display of a mRNA specifically induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in T84 human colon carcinoma cells. Cell Mol. Biol. (Noisy-le-grand) 42 (1996) 797-804
8. Miller F.J., Rosenfeldt F.L., Zhang C., Linnane A.W., and Nagley P. Precise determination of mitochondrial DNA copy number in human skeletal and cardiac muscle by a PCR-based assay: lack of change of copy number with age. Nucleic Acids Res. 31 (2003) e61
9. Ma T., Thiagarajah J.R., Yang H., Sonawane N.D., Folli C., Galietta L.J., and Verkman A.S. Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion. J. Clin. Invest. 110 (2002) 1651-1658
10. Degli Esposti M., Carelli V., Ghelli A., Ratta M., Crimi M., Sangiorgi S., Montagna P., Lenaz G., Lugaresi E., and Cortelli P. Functional alterations of the mitochondrially encoded ND4 subunit associated with Leber's hereditary optic neuropathy. FEBS Lett. 352 (1994) 375-379
11. Shapiro B.L., Feigal R.J., and Lam L.F. Mitochondrial NADH dehydrogenase in cystic fibrosis. Proc. Natl. Acad. Sci .USA 76 (1979) 2979-2983
12. Shapiro B.L., Lam L.F., and Feigal R.J. Mitochondrial NADH dehydrogenase in cystic fibrosis: enzyme kinetics in cultured fibroblasts. Am. J. Hum. Genet. 34 (1982) 846-852
13. Dechecchi M.C., Girella E., Cabrini G., and Berton G. The Km of NADH dehydrogenase is decreased in mitochondria of cystic fibrosis cells. Enzyme 40 (1988) 45-50
14. Shapiro B.L. Evidence for a mitochondrial lesion in cystic fibrosis. Life Sci. 44 (1989) 1327-1334
15. Shapiro B.L. Mitochondrial dysfunction, energy expenditure, and cystic fibrosis. Lancet 2 (1988) 289
16. Gattermann N., Dadak M., Hofhaus G., Wulfert M., Berneburg M., Loeffler M.L., and Simmonds H.A. Severe impairment of nucleotide synthesis through inhibition of mitochondrial respiration. Nucleosides Nucleotides Nucleic Acids 23 (2004) 1275-1279
17. de Meer K., Jeneson J.A., Gulmans V.A., van der Laag J., and Berger R. Efficiency of oxidative work performance of skeletal muscle in patients with cystic fibrosis. Thorax 50 (1995) 980-983
18. DiMauro S. Exercise intolerance and the mitochondrial respiratory chain. Ital J. Neurol. Sci. 20 (1999) 387-393