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Volumn 7, Issue 5, 2012, Pages

Inflammasome-mediated IL-1β production in humans with cystic fibrosis

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; INTERLEUKIN 8; TOLL LIKE RECEPTOR; TRANSMEMBRANE CONDUCTANCE REGULATOR; CASPASE; CFTR PROTEIN, HUMAN;

EID: 84861361851     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0037689     Document Type: Article
Times cited : (56)

References (63)
  • 2
    • 39449133330 scopus 로고    scopus 로고
    • Airway Inflammation in Cystic Fibrosis
    • Elizur A, Cannon CL, Ferkol TW, (2008) Airway Inflammation in Cystic Fibrosis. Chest 133: 489-495.
    • (2008) Chest , vol.133 , pp. 489-495
    • Elizur, A.1    Cannon, C.L.2    Ferkol, T.W.3
  • 4
    • 0033831270 scopus 로고    scopus 로고
    • Exaggerated Activation of Nuclear Factor-kappa B and Altered Ikappa B-beta Processing in Cystic Fibrosis Bronchial Epithelial Cells
    • Venkatakrishnan A, Stecenko AA, King G, Blackwell TR, Brigham KL, et al. (2000) Exaggerated Activation of Nuclear Factor-kappa B and Altered Ikappa B-beta Processing in Cystic Fibrosis Bronchial Epithelial Cells. Am J Respir Cell Mol Biol 23: 396-403.
    • (2000) Am J Respir Cell Mol Biol , vol.23 , pp. 396-403
    • Venkatakrishnan, A.1    Stecenko, A.A.2    King, G.3    Blackwell, T.R.4    Brigham, K.L.5
  • 5
    • 0034816052 scopus 로고    scopus 로고
    • Activation of NF-kappaB in airway epithelial cells is dependent on CFTR trafficking and Cl- channel function
    • Weber AJ, Soong G, Bryan R, Saba S, Prince A, (2001) Activation of NF-kappaB in airway epithelial cells is dependent on CFTR trafficking and Cl- channel function. Am J Physiol Lung Cell Mol Physiol 281: L71-78.
    • (2001) Am J Physiol Lung Cell Mol Physiol , vol.281
    • Weber, A.J.1    Soong, G.2    Bryan, R.3    Saba, S.4    Prince, A.5
  • 6
  • 7
    • 0029286816 scopus 로고
    • Cystic fibrosis lung inflammation: early, sustained, and severe
    • Cantin A, (1995) Cystic fibrosis lung inflammation: early, sustained, and severe. Am J Respir Crit Care Med 151: 939-941.
    • (1995) Am J Respir Crit Care Med , vol.151 , pp. 939-941
    • Cantin, A.1
  • 9
    • 62649139025 scopus 로고    scopus 로고
    • Immunological and Inflammatory Functions of the Interleukin-1 Family
    • Dinarello CA, (2009) Immunological and Inflammatory Functions of the Interleukin-1 Family. Annual Review of Immunology 27: 519-550.
    • (2009) Annual Review of Immunology , vol.27 , pp. 519-550
    • Dinarello, C.A.1
  • 11
    • 79952159132 scopus 로고    scopus 로고
    • Emerging inflammasome effector mechanisms
    • Lamkanfi M, (2011) Emerging inflammasome effector mechanisms. Nat Rev Immunol 11: 213-220.
    • (2011) Nat Rev Immunol , vol.11 , pp. 213-220
    • Lamkanfi, M.1
  • 12
    • 0036671894 scopus 로고    scopus 로고
    • The Inflammasome: A Molecular Platform Triggering Activation of Inflammatory Caspases and Processing of proIL-β
    • Martinon F, Burns K, Tschopp J, (2002) The Inflammasome: A Molecular Platform Triggering Activation of Inflammatory Caspases and Processing of proIL-β. Molecular Cell 10: 417-426.
    • (2002) Molecular Cell , vol.10 , pp. 417-426
    • Martinon, F.1    Burns, K.2    Tschopp, J.3
  • 13
    • 1642285783 scopus 로고    scopus 로고
    • NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder
    • Agostini L, Martinon F, Burns K, McDermott MF, Hawkins PN, et al. (2004) NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder. Immunity 20: 319-325.
    • (2004) Immunity , vol.20 , pp. 319-325
    • Agostini, L.1    Martinon, F.2    Burns, K.3    McDermott, M.F.4    Hawkins, P.N.5
  • 14
    • 32944470765 scopus 로고    scopus 로고
    • Cryopyrin activates the inflammasome in response to toxins and ATP
    • Mariathasan S, Weiss DS, Newton K, McBride J, O'Rourke K, et al. (2006) Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 440: 228-232.
    • (2006) Nature , vol.440 , pp. 228-232
    • Mariathasan, S.1    Weiss, D.S.2    Newton, K.3    McBride, J.4    O'Rourke, K.5
  • 15
    • 3142654767 scopus 로고    scopus 로고
    • Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
    • Mariathasan S, Newton K, Monack DM, Vucic D, French DM, et al. (2004) Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430: 213-218.
    • (2004) Nature , vol.430 , pp. 213-218
    • Mariathasan, S.1    Newton, K.2    Monack, D.M.3    Vucic, D.4    French, D.M.5
  • 16
    • 33744493091 scopus 로고    scopus 로고
    • Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf
    • Miao EA, Alpuche-Aranda CM, Dors M, Clark AE, Bader MW, et al. (2006) Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf. Nat Immunol 7: 569-575.
    • (2006) Nat Immunol , vol.7 , pp. 569-575
    • Miao, E.A.1    Alpuche-Aranda, C.M.2    Dors, M.3    Clark, A.E.4    Bader, M.W.5
  • 17
    • 63649145255 scopus 로고    scopus 로고
    • AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
    • Fernandes-Alnemri T, Yu J-W, Datta P, Wu J, Alnemri ES, (2009) AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature 458: 509-513.
    • (2009) Nature , vol.458 , pp. 509-513
    • Fernandes-Alnemri, T.1    Yu, J.-W.2    Datta, P.3    Wu, J.4    Alnemri, E.S.5
  • 18
    • 63649133278 scopus 로고    scopus 로고
    • AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
    • Hornung V, Ablasser A, Charrel-Dennis M, Bauernfeind F, Horvath G, et al. (2009) AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 458: 514-518.
    • (2009) Nature , vol.458 , pp. 514-518
    • Hornung, V.1    Ablasser, A.2    Charrel-Dennis, M.3    Bauernfeind, F.4    Horvath, G.5
  • 21
    • 59649123905 scopus 로고    scopus 로고
    • Acquisition and eradication of P. aeruginosa in young children with cystic fibrosis
    • Douglas TA, Brennan S, Gard S, Berry L, Gangell C, et al. (2009) Acquisition and eradication of P. aeruginosa in young children with cystic fibrosis. European Respiratory Journal 33: 305-311.
    • (2009) European Respiratory Journal , vol.33 , pp. 305-311
    • Douglas, T.A.1    Brennan, S.2    Gard, S.3    Berry, L.4    Gangell, C.5
  • 22
    • 70249138036 scopus 로고    scopus 로고
    • Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression
    • Bauernfeind FG, Horvath G, Stutz A, Alnemri ES, MacDonald K, et al. (2009) Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression. The Journal of Immunology 183: 787-791.
    • (2009) The Journal of Immunology , vol.183 , pp. 787-791
    • Bauernfeind, F.G.1    Horvath, G.2    Stutz, A.3    Alnemri, E.S.4    MacDonald, K.5
  • 23
    • 28244459680 scopus 로고    scopus 로고
    • Potentiation of Caspase-1 Activation by the P2X7 Receptor Is Dependent on TLR Signals and Requires NF-κB-Driven Protein Synthesis
    • Kahlenberg JM, Lundberg KC, Kertesy SB, Qu Y, Dubyak GR, (2005) Potentiation of Caspase-1 Activation by the P2X7 Receptor Is Dependent on TLR Signals and Requires NF-κB-Driven Protein Synthesis. The Journal of Immunology 175: 7611-7622.
    • (2005) The Journal of Immunology , vol.175 , pp. 7611-7622
    • Kahlenberg, J.M.1    Lundberg, K.C.2    Kertesy, S.B.3    Qu, Y.4    Dubyak, G.R.5
  • 24
    • 0028179929 scopus 로고
    • NF-kappa B regulates IL-1 beta transcription through a consensus NF- kappa B binding site and a nonconsensus CRE-like site
    • Cogswell J, Godlevski M, Wisely G, Clay W, Leesnitzer L, et al. (1994) NF-kappa B regulates IL-1 beta transcription through a consensus NF- kappa B binding site and a nonconsensus CRE-like site. The Journal of Immunology 153: 712-723.
    • (1994) The Journal of Immunology , vol.153 , pp. 712-723
    • Cogswell, J.1    Godlevski, M.2    Wisely, G.3    Clay, W.4    Leesnitzer, L.5
  • 25
    • 12044259166 scopus 로고
    • Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: evidence for a positive autoregulatory loop
    • Hiscott J, Marois J, Garoufalis J, D'Addario M, Roulston A, et al. (1993) Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: evidence for a positive autoregulatory loop. Mol Cell Biol 13: 6231-6240.
    • (1993) Mol Cell Biol , vol.13 , pp. 6231-6240
    • Hiscott, J.1    Marois, J.2    Garoufalis, J.3    D'Addario, M.4    Roulston, A.5
  • 26
    • 0028784322 scopus 로고
    • Inflammatory cytokines in cystic fibrosis lungs [published erratum appears in Am J Respir Crit Care Med 1996 Oct;154(4 Pt 1):following 1217]
    • Bonfield T, Panuska J, Konstan M, Hilliard K, Hilliard J, et al. (1995) Inflammatory cytokines in cystic fibrosis lungs [published erratum appears in Am J Respir Crit Care Med 1996 Oct;154(4 Pt 1):following 1217]. Am J Respir Crit Care Med 152: 2111-2118.
    • (1995) Am J Respir Crit Care Med , vol.152 , pp. 2111-2118
    • Bonfield, T.1    Panuska, J.2    Konstan, M.3    Hilliard, K.4    Hilliard, J.5
  • 27
    • 0032864036 scopus 로고    scopus 로고
    • Distinct sputum cytokine profiles in cystic fibrosis and other chronic inflammatory airway disease
    • Osika E, Cavaillon JM, Chadelat K, Boule M, Fitting C, et al. (1999) Distinct sputum cytokine profiles in cystic fibrosis and other chronic inflammatory airway disease. European Respiratory Journal 14: 339-346.
    • (1999) European Respiratory Journal , vol.14 , pp. 339-346
    • Osika, E.1    Cavaillon, J.M.2    Chadelat, K.3    Boule, M.4    Fitting, C.5
  • 28
    • 28344451370 scopus 로고    scopus 로고
    • Lower Airway Inflammation in Infants with Cystic Fibrosis Detected by Newborn Screening
    • Armstrong DS, Hook SM, Jamsen KM, Nixon GM, Carzino R, et al. (2005) Lower Airway Inflammation in Infants with Cystic Fibrosis Detected by Newborn Screening. Pediatric Pulmonology 40: 500-510.
    • (2005) Pediatric Pulmonology , vol.40 , pp. 500-510
    • Armstrong, D.S.1    Hook, S.M.2    Jamsen, K.M.3    Nixon, G.M.4    Carzino, R.5
  • 30
  • 31
    • 79952228744 scopus 로고    scopus 로고
    • Burkholderia cenocepacia O polysaccharide chain contributes to caspase-1-dependent IL-1beta production in macrophages
    • Kotrange S, Kopp B, Akhter A, Abdelaziz D, Abu Khweek A, et al. Burkholderia cenocepacia O polysaccharide chain contributes to caspase-1-dependent IL-1beta production in macrophages. J Leukoc Biol 89: 481-488.
    • J Leukoc Biol , vol.89 , pp. 481-488
    • Kotrange, S.1    Kopp, B.2    Akhter, A.3    Abdelaziz, D.4    Abu Khweek, A.5
  • 32
    • 77955213128 scopus 로고    scopus 로고
    • Proinflammatory Phenotype and Increased Caveolin-1 in Alveolar Macrophages with Silenced CFTR mRNA
    • Xu Y, Krause A, Hamai H, Harvey B-G, Worgall TS, et al. Proinflammatory Phenotype and Increased Caveolin-1 in Alveolar Macrophages with Silenced CFTR mRNA. PLoS ONE 5: e11004.
    • PLoS ONE , vol.5
    • Xu, Y.1    Krause, A.2    Hamai, H.3    Harvey, B.-G.4    Worgall, T.S.5
  • 33
    • 61549139061 scopus 로고    scopus 로고
    • Macrophages Directly Contribute to the Exaggerated Inflammatory Response in Cystic Fibrosis Transmembrane Conductance Regulator-/- Mice
    • Bruscia EM, Zhang P-X, Ferreira E, Caputo C, Emerson JW, et al. (2009) Macrophages Directly Contribute to the Exaggerated Inflammatory Response in Cystic Fibrosis Transmembrane Conductance Regulator-/- Mice. Am J Respir Cell Mol Biol 40: 295-304.
    • (2009) Am J Respir Cell Mol Biol , vol.40 , pp. 295-304
    • Bruscia, E.M.1    Zhang, P.-X.2    Ferreira, E.3    Caputo, C.4    Emerson, J.W.5
  • 34
    • 28244480768 scopus 로고    scopus 로고
    • Inhibitory Effects of Chloride on the Activation of Caspase-1, IL-1β Secretion, and Cytolysis by the P2X7 Receptor
    • Verhoef PA, Kertesy SB, Lundberg K, Kahlenberg JM, Dubyak GR, (2005) Inhibitory Effects of Chloride on the Activation of Caspase-1, IL-1β Secretion, and Cytolysis by the P2X7 Receptor. The Journal of Immunology 175: 7623-7634.
    • (2005) The Journal of Immunology , vol.175 , pp. 7623-7634
    • Verhoef, P.A.1    Kertesy, S.B.2    Lundberg, K.3    Kahlenberg, J.M.4    Dubyak, G.R.5
  • 35
    • 33847672241 scopus 로고    scopus 로고
    • NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1
    • Miggin SM, Palsson-McDermott E, Dunne A, Jefferies C, Pinteaux E, et al. (2007) NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Proc Natl Acad Sci U S A 104: 3372-3377.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 3372-3377
    • Miggin, S.M.1    Palsson-McDermott, E.2    Dunne, A.3    Jefferies, C.4    Pinteaux, E.5
  • 36
    • 84864288310 scopus 로고    scopus 로고
    • CFTR is a negative regulator of NFkappaB mediated innate immune response
    • Vij N, Mazur S, Zeitlin PL, (2009) CFTR is a negative regulator of NFkappaB mediated innate immune response. PLoS One 4: e4664.
    • (2009) PLoS One , vol.4
    • Vij, N.1    Mazur, S.2    Zeitlin, P.L.3
  • 37
    • 77955382245 scopus 로고    scopus 로고
    • Expression of Wild-Type CFTR Suppresses NF-κB-Driven Inflammatory Signalling
    • Hunter MJ, Treharne KJ, Winter AK, Cassidy DM, Land S, et al. (2010) Expression of Wild-Type CFTR Suppresses NF-κB-Driven Inflammatory Signalling. PLoS ONE 5: e11598.
    • (2010) PLoS ONE , vol.5
    • Hunter, M.J.1    Treharne, K.J.2    Winter, A.K.3    Cassidy, D.M.4    Land, S.5
  • 38
    • 77951240589 scopus 로고    scopus 로고
    • Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome
    • Juliana C, Fernandes-Alnemri T, Wu J, Datta P, Solorzano L, et al. (2010) Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome. J Biol Chem 285: 9792-9802.
    • (2010) J Biol Chem , vol.285 , pp. 9792-9802
    • Juliana, C.1    Fernandes-Alnemri, T.2    Wu, J.3    Datta, P.4    Solorzano, L.5
  • 39
    • 33748146503 scopus 로고    scopus 로고
    • CFTR regulates phagosome acidification in macrophages and alters bactericidal activity
    • Di A, Brown ME, Deriy LV, Li C, Szeto FL, et al. (2006) CFTR regulates phagosome acidification in macrophages and alters bactericidal activity. Nat Cell Biol 8: 933-944.
    • (2006) Nat Cell Biol , vol.8 , pp. 933-944
    • Di, A.1    Brown, M.E.2    Deriy, L.V.3    Li, C.4    Szeto, F.L.5
  • 41
    • 77952043094 scopus 로고    scopus 로고
    • Acidification-dependent activation of CD1d-restricted natural killer T cells is intact in cystic fibrosis
    • Rzemieniak SE, Hirschfeld AF, Victor RE, Chilvers MA, Zheng D, et al. Acidification-dependent activation of CD1d-restricted natural killer T cells is intact in cystic fibrosis. Immunology 130: 288-295.
    • Immunology , vol.130 , pp. 288-295
    • Rzemieniak, S.E.1    Hirschfeld, A.F.2    Victor, R.E.3    Chilvers, M.A.4    Zheng, D.5
  • 42
    • 79952768905 scopus 로고    scopus 로고
    • Nonhematopoietic Cells Are Key Players in Innate Control of Bacterial Airway Infection
    • LeibundGut-Landmann S, Weidner K, Hilbi H, Oxenius A, (2011) Nonhematopoietic Cells Are Key Players in Innate Control of Bacterial Airway Infection. The Journal of Immunology 186: 3130-3137.
    • (2011) The Journal of Immunology , vol.186 , pp. 3130-3137
    • LeibundGut-Landmann, S.1    Weidner, K.2    Hilbi, H.3    Oxenius, A.4
  • 43
    • 34147134534 scopus 로고    scopus 로고
    • Resistance to Pseudomonas aeruginosa Chronic Lung Infection Requires Cystic Fibrosis Transmembrane Conductance Regulator-Modulated Interleukin-1 (IL-1) Release and Signaling through the IL-1 Receptor
    • Reiniger N, Lee MM, Coleman FT, Ray C, Golan DE, et al. (2007) Resistance to Pseudomonas aeruginosa Chronic Lung Infection Requires Cystic Fibrosis Transmembrane Conductance Regulator-Modulated Interleukin-1 (IL-1) Release and Signaling through the IL-1 Receptor. Infect Immun 75: 1598-1608.
    • (2007) Infect Immun , vol.75 , pp. 1598-1608
    • Reiniger, N.1    Lee, M.M.2    Coleman, F.T.3    Ray, C.4    Golan, D.E.5
  • 44
    • 36849056773 scopus 로고    scopus 로고
    • IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice
    • Gasse P, Mary C, Guenon I, Noulin N, Charron S, et al. (2007) IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice. The Journal of Clinical Investigation 117: 3786-3799.
    • (2007) The Journal of Clinical Investigation , vol.117 , pp. 3786-3799
    • Gasse, P.1    Mary, C.2    Guenon, I.3    Noulin, N.4    Charron, S.5
  • 45
    • 63349099346 scopus 로고    scopus 로고
    • The role of interleukin-1beta in murine cigarette smoke-induced emphysema and small airway remodeling
    • Churg A, Zhou S, Wang X, Wang R, Wright JL, (2009) The role of interleukin-1beta in murine cigarette smoke-induced emphysema and small airway remodeling. Am J Respir Cell Mol Biol 40: 482-490.
    • (2009) Am J Respir Cell Mol Biol , vol.40 , pp. 482-490
    • Churg, A.1    Zhou, S.2    Wang, X.3    Wang, R.4    Wright, J.L.5
  • 46
    • 47249131603 scopus 로고    scopus 로고
    • Innate immunity mediated by TLR5 as a novel antiinflammatory target for cystic fibrosis lung disease
    • Blohmke CJ, Victor RE, Hirschfeld AF, Elias IM, Hancock DG, et al. (2008) Innate immunity mediated by TLR5 as a novel antiinflammatory target for cystic fibrosis lung disease. J Immunol 180: 7764-7773.
    • (2008) J Immunol , vol.180 , pp. 7764-7773
    • Blohmke, C.J.1    Victor, R.E.2    Hirschfeld, A.F.3    Elias, I.M.4    Hancock, D.G.5
  • 47
    • 77954924271 scopus 로고    scopus 로고
    • Temporal interleukin-1beta secretion from primary human peripheral blood monocytes by P2X7-independent and P2X7-dependent mechanisms
    • Ward JR, West PW, Ariaans MP, Parker LC, Francis SE, et al. (2010) Temporal interleukin-1beta secretion from primary human peripheral blood monocytes by P2X7-independent and P2X7-dependent mechanisms. J Biol Chem 285: 23147-23158.
    • (2010) J Biol Chem , vol.285 , pp. 23147-23158
    • Ward, J.R.1    West, P.W.2    Ariaans, M.P.3    Parker, L.C.4    Francis, S.E.5
  • 48
    • 64049084303 scopus 로고    scopus 로고
    • Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages
    • Netea MG, Nold-Petry CA, Nold MF, Joosten LA, Opitz B, et al. (2009) Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages. Blood 113: 2324-2335.
    • (2009) Blood , vol.113 , pp. 2324-2335
    • Netea, M.G.1    Nold-Petry, C.A.2    Nold, M.F.3    Joosten, L.A.4    Opitz, B.5
  • 49
    • 45849102043 scopus 로고    scopus 로고
    • ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1β and IL-18 secretion in an autocrine way
    • Piccini A, Carta S, Tassi S, Lasiglié D, Fossati G, et al. (2008) ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1β and IL-18 secretion in an autocrine way. Proceedings of the National Academy of Sciences 105: 8067-8072.
    • (2008) Proceedings of the National Academy of Sciences , vol.105 , pp. 8067-8072
    • Piccini, A.1    Carta, S.2    Tassi, S.3    Lasiglié, D.4    Fossati, G.5
  • 50
    • 79956194922 scopus 로고    scopus 로고
    • Dysfunctional CFTR alters the bactericidal activity of human macrophages against Pseudomonas aeruginosa
    • Del Porto P, Cifani N, Guarnieri S, Di Domenico EG, Mariggio MA, et al. (2011) Dysfunctional CFTR alters the bactericidal activity of human macrophages against Pseudomonas aeruginosa. PLoS ONE 6: e19970.
    • (2011) PLoS ONE , vol.6
    • Del Porto, P.1    Cifani, N.2    Guarnieri, S.3    Di Domenico, E.G.4    Mariggio, M.A.5
  • 51
    • 79960641412 scopus 로고    scopus 로고
    • Defective CFTR expression and function are detectable in blood monocytes: development of a new blood test for cystic fibrosis
    • Sorio C, Buffelli M, Angiari C, Ettorre M, Johansson J, et al. (2011) Defective CFTR expression and function are detectable in blood monocytes: development of a new blood test for cystic fibrosis. PLoS ONE 6: e22212.
    • (2011) PLoS ONE , vol.6
    • Sorio, C.1    Buffelli, M.2    Angiari, C.3    Ettorre, M.4    Johansson, J.5
  • 52
    • 0028015883 scopus 로고
    • Bronchoalveolar lavage findings in cystic fibrosis patients with stable, clinically mild lung disease suggest ongoing infection and inflammation
    • Konstan MW, Hilliard KA, Norvell TM, Berger M, (1994) Bronchoalveolar lavage findings in cystic fibrosis patients with stable, clinically mild lung disease suggest ongoing infection and inflammation. Am J Respir Crit Care Med 150: 448-454.
    • (1994) Am J Respir Crit Care Med , vol.150 , pp. 448-454
    • Konstan, M.W.1    Hilliard, K.A.2    Norvell, T.M.3    Berger, M.4
  • 56
    • 34548225362 scopus 로고    scopus 로고
    • NF-κB Is a Negative Regulator of IL-1β Secretion as Revealed by Genetic and Pharmacological Inhibition of IKKβ
    • Greten FR, Arkan MC, Bollrath J, Hsu L-C, Goode J, et al. (2007) NF-κB Is a Negative Regulator of IL-1β Secretion as Revealed by Genetic and Pharmacological Inhibition of IKKβ. Cell 130: 918-931.
    • (2007) Cell , vol.130 , pp. 918-931
    • Greten, F.R.1    Arkan, M.C.2    Bollrath, J.3    Hsu, L.-C.4    Goode, J.5
  • 57
    • 79955776183 scopus 로고    scopus 로고
    • A Yersinia effector with enhanced inhibitory activity on the NF-kappaB pathway activates the NLRP3/ASC/caspase-1 inflammasome in macrophages
    • Zheng Y, Lilo S, Brodsky IE, Zhang Y, Medzhitov R, et al. (2011) A Yersinia effector with enhanced inhibitory activity on the NF-kappaB pathway activates the NLRP3/ASC/caspase-1 inflammasome in macrophages. PLoS Pathog 7: e1002026.
    • (2011) PLoS Pathog , vol.7
    • Zheng, Y.1    Lilo, S.2    Brodsky, I.E.3    Zhang, Y.4    Medzhitov, R.5
  • 58
    • 0027384590 scopus 로고
    • NF-kappa B subunit-specific regulation of the interleukin-8 promoter
    • Kunsch C, Rosen CA, (1993) NF-kappa B subunit-specific regulation of the interleukin-8 promoter. Mol Cell Biol 13: 6137-6146.
    • (1993) Mol Cell Biol , vol.13 , pp. 6137-6146
    • Kunsch, C.1    Rosen, C.A.2
  • 59
    • 79959242498 scopus 로고    scopus 로고
    • Detection of prokaryotic mRNA signifies microbial viability and promotes immunity
    • Sander LE, Davis MJ, Boekschoten MV, Amsen D, Dascher CC, et al. (2011) Detection of prokaryotic mRNA signifies microbial viability and promotes immunity. Nature 474: 385-389.
    • (2011) Nature , vol.474 , pp. 385-389
    • Sander, L.E.1    Davis, M.J.2    Boekschoten, M.V.3    Amsen, D.4    Dascher, C.C.5
  • 60
  • 61
    • 0035877065 scopus 로고    scopus 로고
    • Type III Protein Secretion Is Associated with Death in Lower Respiratory and Systemic Pseudomonas aeruginosa Infections
    • Roy-Burman A, Savel RH, Racine S, Swanson BL, Revadigar NS, et al. (2001) Type III Protein Secretion Is Associated with Death in Lower Respiratory and Systemic Pseudomonas aeruginosa Infections. Journal of Infectious Diseases 183: 1767-1774.
    • (2001) Journal of Infectious Diseases , vol.183 , pp. 1767-1774
    • Roy-Burman, A.1    Savel, R.H.2    Racine, S.3    Swanson, B.L.4    Revadigar, N.S.5
  • 63
    • 33846837386 scopus 로고    scopus 로고
    • Prevalence of Toll-like receptor signalling defects in apparently healthy children who developed invasive pneumococcal infection
    • Hirschfeld AF, Bettinger JA, Victor RE, Davidson DJ, Currie AJ, et al. (2007) Prevalence of Toll-like receptor signalling defects in apparently healthy children who developed invasive pneumococcal infection. Clin Immunol 122: 271-278.
    • (2007) Clin Immunol , vol.122 , pp. 271-278
    • Hirschfeld, A.F.1    Bettinger, J.A.2    Victor, R.E.3    Davidson, D.J.4    Currie, A.J.5


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