Kinetics, structure, and mechanism of 8-oxo-7,8-dihydro-2′- deoxyguanosine bypass by human DNA polymerase η

Journal of Biological Chemistry

Volumn 289, Issue 24, 2014, Pages 16867-16882

  Patra, Amritraj ^a   Nagy, Leslie D ^a   Zhang, Qianqian ^a   Su, Yan ^a   Müller, Livia ^b   Guengerich, F Peter ^a   Egli, Martin ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOMOLECULES; MACHINERY; MASS SPECTROMETRY; POLYMERS;

DNA COMPLEX; DNA DAMAGES; DNA LESIONS; ERROR PRONES; EXOGENOUS FACTORS; HUMAN DNA POLYMERASE; REPLICATION MACHINERY; TERNARY COMPLEX;

DNA;

8 HYDROXYDEOXYGUANOSINE; ARGININE; DEOXYADENOSINE TRIPHOSPHATE; DEOXYCYTIDINE TRIPHOSPHATE; DEOXYGUANOSINE TRIPHOSPHATE; DNA DIRECTED DNA POLYMERASE ETA;

ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; DNA DAMAGE; ENZYME CONFORMATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DOMAIN; STEADY STATE; X RAY CRYSTALLOGRAPHY;

CRYSTAL STRUCTURE; KINETICS; MASS SPECTROMETRY (MS); OXIDATIVE STRESS; POLYMERASE Η; TRANSVERSION MUTATION; X-RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; CATALYTIC DOMAIN; DNA-DIRECTED DNA POLYMERASE; GUANINE; HUMANS; KINETICS; MOLECULAR DOCKING SIMULATION; MOLECULAR SEQUENCE DATA; NUCLEOTIDES; SUBSTRATE SPECIFICITY;

EID: 84902440216     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.551820     Document Type: Article

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