Isofraxidin, a potent reactive oxygen species (ROS) scavenger, protects human leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in p53-independent manner

Apoptosis

Volumn 19, Issue 6, 2014, Pages 1043-1053

  Li, Peng ^a   Zhao, Qing Li ^a   Wu, Li Hua ^b   Jawaid, Paras ^a   Jiao, Yu Fei ^b   Kadowaki, Makoto ^a   Kondo, Takashi ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

^b HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Calcium; Isofraxidin; Mitochondria; Radio protection; Reactive oxygen species

Indexed keywords

CALCIUM ION; CASPASE 3; CASPASE 8; CYTOCHROME C; FAS ANTIGEN; HYDROXYL RADICAL; ISOFRAXIDIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BAX; PROTEIN P53; RADIOPROTECTIVE AGENT; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; COUMARIN DERIVATIVE; SCAVENGER;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CYTOSOL; DNA FRAGMENTATION; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; RADIATION INDUCED APOPTOSIS; RADIATION INJURY; SIGNAL TRANSDUCTION; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; LEUKEMIA; LYMPHOMA; METABOLISM; RADIATION RESPONSE; TUMOR CELL LINE; X RAY;

APOPTOSIS; CELL LINE, TUMOR; COUMARINS; DRUG SCREENING ASSAYS, ANTITUMOR; FREE RADICAL SCAVENGERS; HUMANS; LEUKEMIA; LYMPHOMA; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; RADIATION-PROTECTIVE AGENTS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53; X-RAYS;

EID: 84902378022     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-014-0984-1     Document Type: Article

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